1,206
Participants
Start Date
December 31, 2007
Primary Completion Date
July 31, 2016
Study Completion Date
September 30, 2016
Defibrotide
"Defibrotide is a single-stranded polydeoxyribonucleotide derived from porcine intestinal mucosa by controlled depolymerisation. Defibrotide has a complex mechanism of action with antithrombotic, anti-ischemic, anti-inflammatory, anti-adhesive and thrombolytic properties but no significant systemic anti-coagulant effects.~Defibrotide is dose intravenously as a 2-hour infusion every 6 hours at a dose of 25 mg/kg/day. Recommended duration of therapy is 21 days."
Defibrotide
New York University School of Medicine, New York
Memorial Sloan Kettering Cancer Center, New York
Mount Sinai Hospital - BMT Program, New York
Mount Sinai Medical Center, New York
Morgan Stanley Children's Hospital - Columbia University Medical Center, New York
Weill Cornell Medical College - New York Presbyterian Hospital, New York
Montefiore Medical Center, The Bronx
New York Medical College, Valhalla
Steven and Alexandra Cohen Children's Medical Center, New Hyde Park
Stony Brook University Hospital, Stony Brook
Roswell Park Cancer Institute, Buffalo
University of Rochester Medical Center, Strong Memorial Hospital, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
West Penn Allegheny Health System, Pittsburgh
Milton S. Hershey Medical Center, Hershey
Geisinger Medical Center, Danville
The Children's Hospital of Philadelphia, Philadelphia
Nemours-Al duPont Hospital for Children, Wilmington
Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
National Institutes of Health, Bethesda
University of Maryland - Greenebaum Cancer Center, Baltimore
Johns Hopkins University, Baltimore
University of Virginia Health System, Charlottesville
Virginia Commonwealth University, Richmond
Children's Hospital of the King's Daughter, Norfolk
Mary Babb Randolph Cancer Center - West Virginia University Hospital, Morgantown
Wake Forest Baptist Health, Winston-Salem
The University of North Carolina at Chapel Hill, Chapel Hill
Duke University Medical Center, Durham
Levine Children's Hospital, Charlotte
Medical University of South Carolina, Charleston
Greenville Health System Cancer Institute, Greenville
Childrens Healthcare of Atlanta, Atlanta
Emory University Hospital, Atlanta
Northside Hospital, Atlanta
UF Health Shands Hospital, Gainesville
Jackson Memorial- University of Miami Health System- Pediatrics, Miami
Nicklaus Children's Hospital (Miami Children's Hospital), Miami
H. Lee Moffitt Cancer Center & Research Institute, Tampa
All Children's Hospital Specialty Physicians, St. Petersburg
Children's Hospital of Alabama, Birmingham
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt Ingram Cancer Center, Nashville
Methodist University Hospital, Memphis
St. Jude Children's Research Hospital - Department of Bone Marrow Transplantation and Cellular Therapy, Memphis
University of Mississippi Medical Center, Jackson
Pediatric Blood and Cancer Disorders Clinic, Louisville
University of Louisville Research Foundation, Louisville
Florida Hospital, Orlando
Nationwide Children's Hospital - Ohio State University College of Medicine (OSUCOM), Columbus
The Ohio State University, James Cancer Hospital, Columbus
Case Western Reserve University (Cwru) - University Hospitals of Cleveland (Uhc), Cleveland
Robert J Tomsich Pathology & Laboratory Medicine Institute, Cleveland
Children's Hospital Medical, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
The Jewish Hospital, Cincinnati
Riley Hospital for Children, Indianapolis
Indiana Blood and Marrow Transplantation Clinical Lab LLC/St. Francis Hospital, Indianapolis
University of Michigan Health System, Ann Arbor
Wayne State University/Children's Hospital of Michigan, Detroit
Henry Ford Hospital, Detroit
Helen DeVos Children's Hospital - Spectrum Health, Grand Rapids
University of Iowa Hospitals & Clinics, Iowa City
Medical College of Wisconsin/ Children's Hospitalof Wisconsin, Milwaukee
University of Wisconsin, American Family Children's Hospital, Medical School, Madison
Children's Hospitals and Clinics of Minnesota and Minneapolis, Minneapolis
University of Minnesota Medical Center, Minneapolis
Mayo Clinic, Rochester
Avera Cancer Institute, Sioux Falls
Cardinal Bernardin Cancer-Loyola University Medical Center, Maywood
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Northwest Memorial Hospital, Chicago
Rush University Medical Center, Chicago
Pediatric Hematology/Oncology MC4060 - University of Chicago, Chicago
Cardinal Glennon Children's Medical Center/St. Louis University Department of Pediatrics, St Louis
Washington University/St. Louis Children's Hospital, St Louis
Children's Mercy Hospital and Clinics - Infectious Diseases, Kansas City
University of Kansas Cancer Center, Kansas City
University of Nebraska Medical Center, Omaha
Tulane University Hospital & Clinic (Tuhc) - Tulane Cancer Center Comprehensive Clinic (Tcccc), New Orleans
Children's Hospital, New Orleans
University of Arkansas for Medical Services, Little Rock
The University of Oklahoma Health Science Center, Oklahoma City
Children's Medical Center of Dallas, Dallas
Cook Children's Health Care Hospital, Fort Worth
Baylor College of Medicine, Houston
Texas Children's Hospital, Houston
The University of Texas - MD Anderson Cancer Center, Houston
University of Texas MD Anderson Cancer Center, Houston
Methodist Healthcare System of San Antonio, San Antonio
San Antonio Military Medical Center, Fort Sam Houston
Children's Hospital Colorado, Aurora
US Oncology - Denver, Denver
University of Utah, Salt Lake City
Phoenix Children's Hospital, Phoenix
Mayo Clinic Cancer Center, Phoenix
Arizona Oncology, Scottsdale
University Medical Center, Tucson
Presbyterian Hospital, Albuquerque
Children's Hospital of Los Angeles, Los Angeles
Long Beach Memorial Medical Center, Long Beach
City of Hope Medical Center, Duarte
The University of California, San Diego, La Jolla
Rady's Children's Hospital - San Diego, San Diego
Loma Linda University, Loma Linda
Children's Hospital of Orange County (CHOC), Orange
University of California San Francisco Medical Center, San Francisco
Stanford University Medical Center, Stanford
Children's Hospital & Research Center Oakland, Oakland
Sutter Institute for Medical Research, Sacramento
University of California Davis Health System, Sacramento
Kapi'olani Medical Center for Women and Children, Honolulu
Doernbecher Children's Hospital - Oregon Health and Science University, Portland
Oregon Health and Science University, Portland
Fred Hutchinson Cancer Research Center/Seattle Children Hospital, Seattle
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Yale - New Haven Hospital, New Haven
Tufts Medical Center, Boston
Massachusetts General Hospital, Boston
Boston Children's Hospital DFCI/CHB-Pediatrics, Boston
Dana-Farber Cancer Institute, Boston
Beth Israel Deaconess Medical Center, Boston
Hackensack University Medical Center - Joseph M. Sanzari Childrens Hospital, Hackensack
Rutgers Cancer Institute of New Jersey, New Brunswick
Lead Sponsor
Jazz Pharmaceuticals
INDUSTRY