751
Participants
Start Date
December 31, 2007
Primary Completion Date
September 5, 2018
Study Completion Date
December 31, 2029
temozolomide
Patients randomized to concomitant temozolomide will receive temozolomide continuously at a daily dose of 75 mg/m² during radiotherapy.
DNA methylation analysis
O6-Methylguanine-DNA Methyltransferase (MGMT) methylation status is used for stratification at randomization.
laboratory biomarker analysis
Prognostic factor analyses
adjuvant therapy
Patients randomized to adjuvant temozolomide will start adjuvant temozolomide after a 4 week resting period after the end of radiotherapy.
quality-of-life assessment
Quality of Life analysis will also be used to assess neurological deterioration free progression
radiation therapy
Radiotherapy will consist of a conventionally fractionated regimen for 6.5 weeks in a once daily schedule
Royal Prince Alfred Hospital, Sydney
Royal North Shore Hospital, St Leonards
Royal Melbourne Hospital, Parkville
Princess Alexandra Hospital, Brisbane
McFarland Clinic, Ames
Arizona Oncology Services Foundation, Phoenix
Cedars-Sinai Medical Center, Los Angeles
UCSF University of California San Francisco Medical Center-Mount Zion, San Francisco
University of Florida, Gainesville
Mayo Clinic in Florida, Jacksonville
Florida Hospital, Orlando
Emory University, Atlanta
Memorial Health University Medical Center, Savannah
Northwestern University, Chicago
Loyola University Medical Center, Maywood
Oncology Associates PC, Fort Wayne
Parkview Hospital, Fort Wayne
Saint Vincent Oncology Center, Indianapolis
June E. Nylen Cancer Center, Sioux City
Via Christi Regional Medical Center, Wichita
Wesley Medical Center, Wichita
Maine Medical Center, Scarborough
Boston Medical Center, Boston
Brigham and Women's Hospital, Boston
Massachussets General Hospital Cancer Center, Boston
Saint Joseph Mercy Hospital, Ann Arbor
Henry Ford Hospital, Detroit
West Michigan Cancer Center, Kalamazoo
St John's Mercy Medical Center, St Louis
Methodist Estabrook Cancer Center, Omaha
Dartmouth Hitchcock Medical Center, Lebanon
State University of New York Upstate Medical University, New York
Highland Hospital, Rochester
University of Rochester - James P. Wilmot Cancer Center, Rochester
Carolinas Medical Center, Charlotte
Akron City Hospital - Summa Health System, Akron
Summa Barberton Hospital, Barberton
Cleveland Clinic Foundation, Cleveland
MetroHealth Medical Center, Cleveland
Western Reserve University, Cleveland
Ohio State University Medical Center, Columbus
Southwest General Health Center Ireland Cancer Center, Middleburg Heights
UHHS-Chagrin Highlands Medical Center, Orange
Cancer Care Center, Incorporated, Salem
UHHS - Westlake Medical Center, Westlake
Cancer Treatment Center, Wooster
Abington Memorial Hospital, Abington
Lehigh Valley Hospital, Allentown
UPMC - Heritage Valley Health System - The Medical Center, Beaver
Penn State M.S. Hershey Medical Center, Hershey
Thomas Jefferson University Hospital, Philadelphia
Reading Hospital and Medical Center, West Reading
Medical University of South Carolina, Charleston
Cancer Centers of the Carolinas - Eastside, Greenville
Cancer Centers of the Carolinas - Faris Road, Greenville
Cancer Centers of the Carolinas - Greer Radiation Oncology, Greer
Cancer Centers of the Carolinas - Seneca, Seneca
Spartanburg Regional Medical Center, Spartanburg
Rapid City Regional Hospital, Rapid City
University of Texas Medical Branch, Galveston
Md Anderson Cancer Center, Houston
Methodist Hospital, Houston
Intermountain Medical Center, Murray
Utah Valley Regional Medical Center, Provo
LDS Hospital, Salt Lake City
University Of Utah - Huntsman Cancer Institute, Salt Lake City
Dixie Medical Center Regional Cancer Center, St. George
Virginia Commonwealth University, Richmond
Swedish Cancer Institute, Seattle
Virginia Mason CCOP, Seattle
Saint Mary's Hospital, Green Bay
Saint Vincent Hospital, Green Bay
Gundersen Lutheran, La Crosse
University Of Wisconsin Comprehensive Cancer Center, Madison
Froedtert and the Medical College of Wisconsin, Milwaukee
Waukesha Memorial Hospital, Waukesha
Flinders Medical Centre, Bedford Park
Austin-Repatriation Medical Centre, Heidelberg
Royal Hobart Hospital, Hobart
St Vincent'S Hospital, Melbourne
Sir Charles Gairdner Hospital, Nedlands
Alfred Hospital, Prahran
ZNA Middelheim, Antwerp
Cliniques Universitaires St. Luc, Brussels
Universitair Ziekenhuis Brussel, Brussels
Clinique Notre-Dame, Charleroi
Algemeen Ziekenhuis Sint Lucas, Ghent
U.Z. Gasthuisberg, Leuven
Tom Baker Cancer Centre, Calgary
London Regional Cancer Center, London
Allan Blair Cancer Centre, Saskatoon
University Health Network - Oci / Princess Margaret Hospital, Toronto
Cancercare Manitoba, Winnipeg
Assistance Publique - Hôpitaux de Marseille - C.H.U. De La Timone, Marseille
C.H.U. de Nancy - Hopital St Julien, Nancy
Centre Antoine Lacassagne, Nice
Chu Pitie-Salpetriere AP-HP, Paris
Centre Eugene Marquis, Rennes
Institut Gustave Roussy, Villejuif
Klinikum Bamberg, Bamberg
Universitaetsklinikum Bonn, Bonn
Medizinische Hochschule Hannover, Hanover
UniversitaetsKlinikum Heidelberg, Heidelberg
Universitaetskliniken Regensburg, Regensburg
Universitaetsklinikum Tuebingen, Tübingen
Tel Aviv Sourasky Medical Center, Tel Aviv
Ospedale Bellaria, Bologna
Istituto Scientifico H.S. Raffaele, Milan
Azienda Ospedaliera San Giovanni Battista Di Torino-Universita Di Torino, Torino
Academisch Medisch Centrum - Universiteit van Amsterdam, Amsterdam
Vrije Universiteit Medisch Centrum, Amsterdam
University Medical Center Groningen, Groningen
Maastro Clinic - Maastricht Radiation Oncology, Maastricht
Radboud University Nijmegen Medical Centre, Nijmegen
Erasmus MC - Daniel den Hoed Cancer Center, Rotterdam
Medisch Centrum Haaglanden - Westeinde, The Hague
Hospital Clinic Universitari, Barcelona
ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia), Barcelona
Hopital Cantonal Universitaire De Geneve, Geneva
Universitaetsspital, Zurich
University Hospitals Bristol NHS Foundation Trust - Bristol Haematology And Oncology Centre, Bristol
Addenbrookes Hospital, Cambridge
Cheltenham General Hospital, Cheltenham
Western General Hospital, Edinburgh
Royal Devon And Exeter Hospital, Exeter
St. James'S University Hospital, Leeds
Christie NHS Foundation Trust, Manchester
Clatterbridge Centre for Oncology NHS Trust, Metropolitan Borough of Wirral
Nottingham University Hospitals NHS Trust - City Hospital campus, Nottingham
Derriford Hospital, Plymouth
Weston Park Hospital, Sheffield
Royal Marsden Hospital, Sutton
Collaborators (2)
NCIC Clinical Trials Group
NETWORK
Radiation Therapy Oncology Group
NETWORK
Medical Research Council
OTHER_GOV
Merck Sharp & Dohme LLC
INDUSTRY
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK