BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab

PHASE3TerminatedINTERVENTIONAL
Enrollment

3,509

Participants

Timeline

Start Date

April 30, 2008

Primary Completion Date

June 30, 2013

Study Completion Date

July 31, 2014

Conditions
Breast Cancer
Interventions
DRUG

Docetaxel

"75 mg/m2 IV on day 1 every 3 weeks for cycles 1-6, Arms 1A and 1B~100 mg/m2 on day 1 every 3 weeks for cycles 1-3, Arms 2A and 2B"

DRUG

Trastuzumab

"First dose: 8 mg/kg IV on day 1 of cycle 1 only. Subsequent doses: 6 mg/kg IV on day 1 every 3 weeks for cycles 2-6. Following completion of chemotherapy cycles: 6 mg/kg IV every 3 weeks until 1 year following first trastuzumab dose. Arms 1A and 1B~First dose: 8 mg/kg IV on day 1 of cycle 1 only. Subsequent doses: 6 mg/kg IV on day 1 every 3 weeks for cycles 2-3. 21 days after last dose of FEC: 8 mg/kg IV first post-FEC dose only; subsequent doses 6 mg/kg IV every 3 weeks for a total of 1 year. Arms 2A and 2B"

DRUG

Carboplatin

6 mg/ml/min IV on day 1 every 3 weeks for cycles 1-6

DRUG

Bevacizumab

"15 mg/kg IV on day 1 every 3 weeks for cycles 1-6. Following completion of chemotherapy cycles: 15 mg/kg IV on day 1 every 3 weeks until 1 year following first bevacizumab dose. Arm 1B~15 mg/kg IV on day 1 every 3 weeks for cycles 1-3. 21 days after the last dose of FEC: 15 mg/kg IV on day 1 every 3 weeks until 1 year following first bevacizumab dose. Arm 2B"

DRUG

5-Fluorouracil

600 mg/m2 IV on day 1 every 3 weeks for cycles 4-6

DRUG

Epirubicin

90 mg/m2 IV on day 1 every 3 weeks for cycles 4-6

DRUG

Cyclophosphamide

600 mg/m2 IV on day 1 every 3 weeks for cycles 4-6

Trial Locations (649)

8

St. James's Hospital, Dublin

112

Sun Yat-Sen Cancer Center, Taipei

Taipei Veterans General Hospital, Taipei

500

Changhua Christian Hospital, Changhua

704

National Cheng Kung University, Tainan City

807

Kaohsiung Medical University Chung, Kaohsiung City

1082

Semmelweis Egyetem Clinic of Radiology, Budapest

1090

AKH Vienna, Vienna

Medizinische Universitaet Wien-Allgemeines Krankenhaus, Onkologie, Vienna

1130

Krankenhaus Hietzing, Gynaekologische Abteilung, Vienna

1340

Clinique St Pierre, Ottignies

1527

"MHAT Tsaritsa Yoanna-ISUL EOOD", Sofia

1871

Cancer Therapy Center, Liverpool

2065

North Shore Private Hospital, St Leonards

Royal North Shore Hospital, St Leonards

2101

University Clinical Centre, Maribor

2217

St. George Hospital, Kogarah

2500

Southern Medical Day Care, Wollongong

2560

Macarthur Cancer Center, Campbelltown

2610

Medical Institute St. Augustinus, Wilrijk

2930

AZ Klina, Brasschaat

3004

The Alfred Hospital, Melbourne

3199

Frankston Hospital, Frankston

3330

Chang Gung Memorial Hospital, Taoyuan District

4000

District Oncology Dispensary Plovdiv, Plovdiv

4001

Hopelands Cancer Centre, Durban

4010

Krankenhaus Barmherzige Schwestern Linz, Kooperative Studiengruppe, Chirurgie, Linz

4012

DEOEC Onkologiai Tanszek, Debrecen

4029

Royal Brisbane & Women's Hospital, Herston

4101

Mater Adult Hospital, South Brisbane

4600

Klinikum Wels-Grieskirchen, Kooperative Gruppe Wels/4. Medizinische Abteilung, Wels

4840

Landeskrankenhaus Voecklabruck, 2. Medizinische Abteilung, Vöcklabruck

5020

AI Universitätsklinikum der PMU Landeskliniken, Salzburg

5035

Ashford Cancer Center, Ashford

5042

Flinders Medical Centre, Bedford

6000

Mount Medical Center, Perth

C. H. Notre-Dame and Reine Fabiola, Charleroi

Cebu Doctors University Hospital, Cebu City

6008

Berdat Family Comprehensive Cancer Centre, Subiaco

6010

Hospital Perpetuo Socorro, Badajoz

6330

Bezirkskrankenhaus Kufstein, Innere Medizin, Kufstein

8020

Krankenhaus Barmherzige Brueder Graz, Medizinische Abteilung, Graz

8036

Universitatsfrauenklinik Graz, Graz

8700

Landeskrankenhaus Leoben, Abteilung fur Haemato-Onkologie, Leoben

9301

Department of Oncotherapy National Hospital, Bloemfontein

10000

University Hospital Zagreb, Zagreb

10003

Beth Israel Medical Center, New York

Hospital De San Pedro de Alcantara, Cáceres

10019

St. Luke's-Roosevelt Hospital Center, New York

10330

Chulalongkorn Hospital, Patumwan

10400

National Cancer Institute, Bangkok

11080

Clinical Hospital Center Bezanijska Kosa, Belgrade

11794

University Hospital and Medical Center - SUNY, Stony Brook

University Hospital and Medical Center-SUNY, Stony Brook

11796

National Cancer Institute, Cairo

12010

Amsterdam Community Cancer Program, Amsterdam

Hematology Oncology Assaociates of CNY, CCOP, East Syracuse

12110

NY Oncology Hematology PC- Latham- Capital District Oncology Hematology, Latham

12148

Riverview Cancer Care Medical Association, Rexford

12180

Troy Cancer Treatment Program, Troy

12206

New York Oncology Hematology PC-Albany, Albany

12208

NY Oncology Hematology PC at Albany Medical Center, Albany

12534

NY Oncology Hematology PC-Hudson Carvell Cancer Tx Prog., Hudson

13008

Hopital St. Joseph, Marseille

13100

Meir Medical Center, Kfar

13215

Hematology Oncology Assoc. of CNY, CCOP (Comm. General Hospital Satellite Office), Syracuse

13440

Hematology Oncology Associates of CNY, CCOP, Rome

14424

Interlakes Oncology & Hematology, P.C., Canandaigua

15006

Complejo Hospitalario Universitario A Coruna, A Coruña

15009

Centro Oncologico de Galicia, A Coruña

15090

UPMC Cancer Centers - Wexford, Wexford

15132

UPMC Cancer Centers - McKeesport Hospital, McKeesport

15212

Allegheny General Hospital/Allegheny-Singer Research Institute, Pittsburgh

NSABP Foundation, Inc, Pittsburgh

15213

University of Pittsburgh, Pittsburgh

15215

UPMC Cancer Centers - UPMC St. Margaret, Pittsburgh

15232

Hillman Cancer Center, Pittsburgh

15237

UPMC Cancer Centers - UPMC Passavant, Pittsburgh

15401

UPMC Cancer Centers-Uniontown, Uniontown

15601

UPMC Cancer Centers Arnold Palmer Pavilion-Mountainview, Greensburg

UPMC Cancer Centers Arnold Palmer-Oakbrook, Greensburg

15666

UPMC Cancer Centers Arnold Palmer-Mt. Pleasant, Mount Pleasant

15701

UPMC Cancer Centers-Indiana, Indiana

15901

UPMC Cancer Centers-John P. Murtha Cancer Center, Johnstown

16803

Mount Nittany Medical Center, State College

17007

Instituto Catalan Oncologia de Girona, Girona

17403

York Hospital, York

17522

Ephrata Cancer Center at Ephrata Community Hospital, Ephrata

18000

Clinic of Oncology, Clinical Center nis, Niš

18105

Lehigh Valley Hospital, Allentown

18142

Hematology Oncology Associates of NE PA, Donora

18501

Mercy Hospital, Scranton

Scranton Hematology Oncology, Scranton

18510

Hematology and Oncology Associates, Scranton

19063

Riddle Memorial Hospital, Media

19107

Kimmel Cancer Center at Jefferson, Philadelphia

19115

Cancer Center at Center One, Philadelphia

19229

CCOP, St. John Hospital and Medical Center, Grosse Pointe Woods

19718

CCOP, Christiana Care Health Services Inc., Newark

20010

Washington Cancer Institute, Washington D.C.

20016

Sibley Memorial Hospital, Washington D.C.

20037

Washington Oncology-Hematology Center, PC-Washington, Washington D.C.

20815

The Office of Frederik Smith, Chevy Chase

Washington Oncology-Hematology Center, PC-Chevy Chase, Chevy Chase

20817

Carolyn Hendricks, MD, Bethesda

Suburban Hospital, Bethesda

Peninsula Regional Oncology & Hematology, Salisbury

20850

Associates in Oncology/Hematology, Rockville

20902

Oncology Care Associates, Wheaton

20910

Holy Cross Hospital, Silver Spring

21202

Mercy Medical Center, Baltimore

21204

Greater Baltimore Medical Center, Baltimore

21237

Franklin Square Hospital Center, Baltimore

Harry & Jeannette Weinberg Cancer Institute, Baltimore

Hematology-Oncology Associates, Baltimore

21801

Peninsula Regional Medical Center, Salisbury

22300

Hospital Comarcal de Barbastro, Barbastro

23007

Complejo Hospitalario de Jaen, Jaén

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

MBCCOP, Virginia Commonwealth University, Richmond

26789

Onkologische schwerpunktpraxis, Leer

27100

Fondazione Salvatore Maugeri, Pavia

27403

Moses Cone Regional Cancer Center, Greensboro

27518

Waverly Hematology Oncology, Gary

27534

CCOP, Wayne Memorial Hospital, Goldsboro

28007

Hospital Universitario Gregorio Maranon, Madrid

28034

Hospital Ruber International, Madrid

28040

Fundacion Jimenez Diaz, Madrid

Hospital Universitario San Carlos, Madrid

28050

"Centro Integral de Oncologia Clara Campal", Madrid

28078

Carolina BioOncology Institute, Huntersville

28203

Carolinas Hematology-Oncology Associates - Tyron St, Charlotte

28204

Carolinas Medical Center - Blumenthal Cancer Center, Charlotte

CCOP Presbyterian Hospital, Charlotte

Mecklenburg Medical Group - Morehead Medical Dr, Charlotte

28211

Mecklenburg Medical Group - Cameron Valley Pkwy, Charlotte

28262

Carolinas Hematology Oncology Associates - Harris Blvd., Charlotte

28277

Carolinas Hematology-Oncology - John J. Delaney, Charlotte

28603

Northwestern Carolina Oncology & Hematology, PA, Hickory

28801

Cancer Care of Western North Carolina, Asheville

CCOP, Mission Hospitals, Inc., Asheville

28803

Cancer Center of NC at Asheville, Asheville

28922

Fundacion Hospitalaria de Alcorcon, Alcorcón

29010

Hospital Clinico Virgen de la Victoria, Málaga

Hospital Univesitario Carlos Haya, Málaga

29609

CHU Morvan, Brest

30045

Suburban Hematology-Oncology Associates, Lawrenceville

30060

Georgia Cancer Specialists, Marietta

30078

Suburban Hematology Oncology Associates PC, Snellville

30106

Northwest Georgia Oncology Centers PC, Austell

30117

Northwest Georgia Oncology Centers PC, Carrollton

30121

Northwest Georgia Oncology Centers PC, Cartersville

30167

Klinikum Hannover Nordstadt, Hanover

30303

Grady Healthsystem, Atlanta

30322

Emory University, Atlanta

30607

Northeast Georgia Cancer Care, LLC, Athens

30901

Augusta Oncology Associates, Augusta

31052

Institution Claudius Regaud, Toulouse

31201

Central Georgia Cancer Care, Macon

31217

Georgia Cancer Specialists, Macon

31400

Polyclinique du Parc, Toulous

31655

Klinikum Schaumburg, Stadhagen

31701

Phoebe Putney Memorial Hospital, Albany

31785

Kreiskrankenhaus Hameln, Hamelin

32073

Integrated Community Oncology Network, Orange Park

32258

Integrated Community Oncology Network, Jacksonville

32605

Robert R. Carroll, MD, PA, Gainesville

32804

Florida Hospital Cancer Institute, Orlando

33106

Hospital Universitario Insular de Gran Canaria, Las Palmas

33300

Clinique Bordeaux Nord Aquitaine, Bordeaux

33394

Hospital de Cabueñes, Oncologia Médica, Gijón

33401

Palm Beach Cancer Institute, West Palm Beach

33428

Lynn Cancer Institute, Boca Raton

33511

Florida Cancer Specialists, Brandon, Brandon

33603

Florida Cancer Specialists, Tampa

33614

Florida Cancer Specialists, Tampa

33756

Florida Cancer Specialists, Clearwater

Florida Cancer Specialists-Park Place, St. Petersburg

33805

Lakeland Regional Cancer Center, Lakeland

33901

Florida Cancer Specialists-Fort Myers Broadway, Fort Myers

33908

Florida Cancer Specialists-Fort Myers Summerlin, Fort Myers

33914

Florida Cancer Specialists-Cape Coral Parkway, Cape Coral

33980

Florida Cancer Specialists-Port Charlotte, Port Charlotte

33990

Florida Cancer Specialists-Cape Coral Del Prado, Cape Coral

34102

Florida Cancer Specialists-Naples Goodlette, Naples

34119

Florida Cancer Specialists-NAPA Ridge, Naples

34135

Florida Cancer Specialists-Bonita Springs, Bonita Springs

34209

Florida Cancer Specialists-Bradenton, Bradenton

34223

Florida Cancer Specialists-Englewood, Englewood

34232

Florida Cancer Specialist-Cattleman, Sarasota

34236

Florida Cancer Specialists-Downtown, Sarasota

34285

Florida Cancer Specialists-Venice Island, Venice

34292

Florida Cancer Specialists-Venice, Venice

34298

Centre Regional de Lutte contre le Cancer (CRLC) Val d'Aurelle, Montpellier

34684

Florida Cancer Specialists, Cornerstone, Palm Harbor

35294

University of Alabama at Birmingham, Birmingham

35423

Asklepios Kliniken Lich GmbH, Lich

35601

Clearview Cancer Institute-Decatur, Decatur

35801

Clearview Cancer Institute, Huntsville

35805

Clearview Cancer Institute- Huntsville, Huntsville

36001

Complejo Hospitalario de Pontevedra, Pontevedra

36043

Medizinisches Versorgungszentrum Osthessen, Fulda

37007

Hospital Universitario de Salamanca, Salamanca

37804

Thompson Oncology Group-Blount, Knoxville

37909

Thompson Cancer Survival Center-Dowell Springs, Knoxville

37916

Thompson Cancer Survival Center, Knoxville

37932

Thompson Oncology Group-West, Knoxville

38028

Institut Daniel Hollard, Grenoble

38120

The West Clinic, Memphis

38320

Hospital Universitario de Canarias, San Cristóbal de La Laguna

38671

University of Tennessee Cancer Institute, Southaven

40202

NortonHealthcare Pavillion, Louisville

40207

Norton Medical Plaza II, Louisville

40217

Norton Medical Plaza West, Louisville

40235

Luisenkrankenhaus, Düsseldorf

40241

Old Brownsboro Crossing, Louisville

40536

University of Kentucky Medical Center, Lexington

41013

Hospital Universitario Virgen del Rocio, Seville

41061

Ev Krankenhaus Bethesda, Mönchengladbach

41345

Sahlgrenska University Hospital, Gothenburg

43537

Northwest Ohio Oncology Center, Maumee

43560

Flower Memorial Hospital, Sylvania

43616

Bayview Oncology Associates, Toledo

43617

Toledo Clinic, Toledo

44106

Case Western Reserve/University Hospitals-Ireland Cancer Cntr., Cleveland

44121

UHHS Green Road-Ireland Cancer Center, South Euclid

44122

UHHS - Chagrin Highlands, Orange

44145

UHHS Westlake-Ireland Cancer Center, Westlake

44202

Centre Catherine de Sienne, Nantes

44304

Akron City Hospital, Akron

44307

Akron General Medical Center, Akron

44601

Alliance Cancer Center, Alliance

44710

Aultman Hospital, Canton

44781

Tri County Hematology/Oncology, Canton

45013

Hamilton Office, Hamilton

45014

Healthplex, Fairfield

45122

Universitaetsfrauenklinik, Essen

45236

Kenwood Office, Cincinnati

Oncology/Hematology Care Clinical Trials LLC, Cincinnati

45242

North Treatment Center - Blue Ash Medical Center, Cincinnati

Oncology/Hematology Care Clinical Trials LLC, Cincinnati, OH Blue Ash Med. Cntr. (Administrative Only), Cincinnati

Oncology/Hematology Care Clinical Trials LLC, Cincinnati

45331

Dayton Physicians, LLC - Greenville, Greenville

45415

Dayton Physicians-LLC-Hematology & Medical Oncology Division, Dayton

45429

Dayton Clinical Oncology Program-Kettering, Kettering

Marian A. Llenado Lee, MD, Inc., Kettering

45657

Praxis und Tagesklinik fuer Onkologie und, Recklinghausen

46010

Hospital Clinico Universitario de Valencia, Valencia

46117

South Bend Clinic, South Bend

46350

Michiana Hematology-Oncology, P.C. (LaPorte), La Porte

46514

Elkhart Clinic, Elkhart

Michiana Hematology-Oncology, P.C. (Elkhart), Elkhart

46563

Michiana Hematology-Oncology PC, Plymouth

Oncology, P.C. Plymouth, Plymouth

46601

Michiana Hematology-Oncology, P.C. (Main Office), South Bend

Northern Indiana Cancer Research Consortium, South Bend

46617

Michiana Hematology-Oncology, P.C. Cedar St., South Bend

46904

Howard Regional Health System, Kokomo

47112

Corydon Hospital Medical Plaza, Corydon

47130

Clark Medical Building, Jeffersonville

47150

Cancer Care Center, New Albany

47403

Cancer Care of Southern Indiana, Bloomington

47802

Providence Medical Group, Terre Haute

48043

Community Cancer Care Specialists-Mt. Clemens, Mount Clemens

Mount Clemens Regional Medical Center, Mount Clemens

48073

CCOP, William Beaumont Hospital, Royal Oak

48093

CCOP, St. John Macomb Hospital, Warren

48106

CCOP, St. Joseph Mercy Hospital, Ann Arbor

48114

St. Joseph Mercy Woodland Health Center, Brighton

48126

Henry Ford Medical Center-Fairlane, Dearborn

48129

Universitaetsklinikum Munster, Münster

48144

Hematology/Oncology Associates of OH and MI, PC, Lambertville

48154

St. Mary Mercy Hospital - Livonia, Livonia

48183

Josephone Ford Cancer Center, Brownstown

48202

Henry Ford Hospital, Detroit

48315

Osteopathic Medical Oncology Hematology, Shelby

48322

Henry Ford Medical Center-West Bloomfield, West Bloomfield

48439

Genesys Regional Medical Center, Grand Blanc

48446

Hematology Oncology-Lapeer, Lapeer

Lapeer Regional Hospital, Lapeer

48503

CCOP Hurley Medical Center, Flint

Genesys Hurley, Flint

48532

Sing and Arora, Flint

48601

CCOP, St. Mary's Medical Center, Saginaw

48706

Bay Regional Medical Center, Bay City

Dr. Cook and Abramson - Bay City, Bay City

48909

CCOP, Sparrow Health System, Lansing

48910

Michigan State University - Breslin Cancer Center, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49016

Battle Creek Health System, Battle Creek

49085

Lakeside Cancer Specialists, PLLC, Saint Joseph

Michiana Hematology-Oncology, PC Lakeland, Saint Joseph

49120

Michiana Hematology-Oncology PC, Niles

49221

Bixby Medical Center, Adrian

49443

Hackley Hospital, Muskegon

49503

Grand Rapids Clinical Oncology Program, Grand Rapids

Spectrum Health Hospitals, Grand Rapids

St. Mary's Health Services, Grand Rapids

49519

Metro Health Hospital, Wyoming

49684

Munson Medical Center, Traverse City

49783

Chippewa Medical Associates, Sault Ste. Marie

49801

UP Hematology/Oncology Associates, Iron Mountain

49829

UP Hematology/Oncology Assoc.-Doctor's Park Family Physicians, Escanaba

49855

Marquette General Hospital, Marquette

Upper Peninsula Hematology/Oncology Associates, Marquette

49913

Keewanaw Memorial Hospital, Laurium

49935

Portage Internal Medical Associates, Hancock

49938

UP Hematology/Oncology Associates-Gogebic Range, Ironwood

50009

Hospital Clinico Universitario Lozano Blesa, Zaragoza

Hospital U. Miguel Servet, Zaragoza

51014

Tartu University Hospital Clinic of Hematology and Oncology, Tartu

52242

University of Iowa, Iowa City

52722

Hematology and Medical Oncology Consultants-Bettendorf, Bettendorf

52804

Hematology and Medical Oncology Consultants-Davenport, Davenport

53051

Oncology Alliance-Menomonee Falls, Menomonee Falls

53092

Oncology Alliance-Mequon, Mequon

53105

Oncology Alliance-Burlington, Burlington

53132

Oncology Alliance-Franklin, Franklin

53143

Oncology Alliance-Kenosha South, Kenosha

53144

Oncology Alliance-Kenosha North, Kenosha

53188

Oncology Alliance-Waukeska, Waukesha

53212

Oncology Alliance, Glendale

53215

Oncology Alliance-South, Milwaukee

53406

Oncology Alliance-Racine, Racine

54311

Aurora BayCare Medical Center, Green Bay

54449

CCOP, Marshfield Clinic, Marshfield

54476

Marshfield Clinic Weston Center, Weston

55101

Universitaetsklinikum Mainz, Mainz

55102

Minnesota Hematology Oncology-St. Paul, Saint Paul

55109

Minnesota Oncology Hematology PA - Maplewood, Maplewood

55125

Minnesota Oncology Hematology, Woodbury

55131

St. Vincenz u. Elisabeth Hospital, Mainz

55337

Minnesota Oncology Hematology-Burnsville, Burnsville

Park Nicollet Clinic, Burnsville

55387

Minnesota Oncology Hematology-Waconia, Waconia

55407

Minnesota Oncology Hematology-Minneapolis, Minneapolis

55416

Park Nicollet Health Services, Saint Louis Park

55422

Hubert H. Humphrey Cancer Center-Robbinsdale, Robbinsdale

55432

Hubert H. Humphrey Cancer Center - Fridley, Fridley

55433

Hubert H. Humphrey Cancer Center - Coon Rapids, Coon Rapids

55435

Minnesota Oncology Hematology-Edina, Edina

55455

Fairview Southdale Medical Oncology Clinic, Edina

56429

"P.G. Hospital of Thessaloniki Papageorgiou", Thessaloniki

59101

Hematology Oncology Centers of the Northern Rockies, Billings

59187

Centre Leonard de Vinci, Dechy

60000

CH-Service Hemato-Oncologie, Beauvais

60005

Cancer Care & Hematology Specialists of Chicagoland, Arlington

60190

Cancer Care and Hematology Specialists of Chicagoland, Winfield

60540

Edward Hospital, Naperville

60560

Yorkville Family Practice, Yorkville

60585

Edward Cancer Center Plainfield, Plainfield

60612

MBCCOP, John H. Stroger, JR., Hospital of Cook County-Chicago, Chicago

Rush University Medical Center, Chicago

61231

Hochwaldkrankenhaus, Bad Nauheim

62401

Crossroads Cancer Center, Decatur

62526

Cancer Care Specialists-Central Illinois, Decatur

Decatur Memorial Hospital, Decatur

63450

Klinikum Stadt Hanau, Hanau

64060

Opcion Oncologia, Monterrey

64111

Saint Luke's Hospital, Kansas City

64131

CCOP, Kansas City (Administrative Only), Kansas City

64804

Freeman Cancer Institute, Joplin

St. John's Regional Health Center-Joplin, Joplin

65203

University of Missouri-Ellis Fischel, Columbia

65805

St. John's Regional Health Center, Springfield

65807

Cox Health Systems, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66100

(Azienda u.s.I. chieti) - Policinico Ospedaliero, Chieti

67000

Pole de cancerologie prive, Strasbourg

67085

CLCC Paul Strauss, Strasbourg

68024

Hopital Pasteur, Colmar

70376

Robert-Bosch-Krankenhaus, Stuttgart

70806

Baton Rouge General Medical Center, Baton Rouge

71000

Clinical Centre University of Sarajevo, Sarajevo

71032

Klinikverbund Suedwest - Sindelfingen-Böeblingen Clinical Centre, Böeblingen

75004

CHU Hotel Dieu, Paris

75075

North Texas Regional Cancer Center, Plano

75246

Texas Oncology- Sammons CC, Dallas

75571

Hopital St. Antoine, Paris

76000

Clinique Saint Hilaire, Rouen

76104

The Center for Cancer and Blood Disorders, Fort Worth

77030

Baylor College of Medicine, Houston

Ben Taub General Hospital, Houston

79410

Covenant Health System dba Joe Arrington Cancer Research & Treatment Center, Lubbock

80026

Kaiser Permanente Rock Creek, Lafayette

80033

Exempla Lutheran Medical Center, Wheat Ridge

80045

University of Colorado Cancer Center, Aurora

80054

CHU D'Amiens, Amiens

80131

IRCCS - Instituto Nazionale per lo Studio e la Cura, Napoli

80205

Kaiser Permanente-Franklin, Denver

80210

Cypress Hematology/Oncology, Denver

80218

Rocky Mountain Cancer Center - Midtown, Denver

80224

CCOP-Colorado Cancer Research Prog. Inc.(Administrative Only), Denver

80538

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

80637

RotKreuzKlinikum München GmbH, Munich

80907

Penrose Cancer Center, Colorado Springs

81632

Shaw Regional Cancer Center, Edwards

83022

Klinikum Rosenheim, Rosenheim

83278

Fachärzte fürlnnere Medizin, Hämatologie, Traunstein

83301

Mountain States Tumor Institute, Twin Falls

83642

Mountain States Tumor Institute, Meridian

83814

Kootenai Cancer Center, Coeur d'Alene

84107

Intermountain Medical Center, Murray

84143

LDS Hospital, Salt Lake City

84403

McKay-Dee Hospital, Ogden

84604

Utah Valley Regional Medical Center, Provo

84780

Dixie Medical Center, St. George

85925

CHD les Oudairies, La Roche-sur-Yon

86001

Northern Arizona Hematology & Onclogy Associates, Flagstaff

86336

Northern Arizona Hematology & Oncology Associates, Sedona

87039

Clinique Francois Chenieux, Limoges

87042

CHU Dupuytren, Limoges

89052

Comprehensive Cancer Centers of Nevada (Siena), Henderson

89102

University Medical Center of Southern Nevada, Las Vegas

89106

Cancer and Blood Specialists- Shadow Lane, Las Vegas

Cancer Consultants, Las Vegas

89135

Nevada Cancer Institute, Las Vegas

89502

Renown Regional Medical Center, Reno

89503

Alpine Hematology-Oncology, Reno

90027

Kaiser Permanente-Sunset, Los Angeles

90034

Kaiser Permanente-West Los Angeles, Los Angeles

90250

Breastlink Medical Group, Inc, Hawthorne

90277

Cancer Care Associates Medical Group, Inc., Redondo Beach

90706

Kaiser Permanente-Bellflower, Bellflower

91042

Kaiser Permanente-Panorama City, Panorama City

91355

UCLA/Santa Clarita Valley Cancer Center, Valencia

91367

Kaiser Permanente-Woodland Hills, Woodland Hills

91505

Providence Saint Joseph Medical Center, Burbank

91706

Kaiser Permanente-Baldwin Park, Baldwin Park

91750

Wilshire Oncology Medical Group, Pasadena

91801

Central Hematology/Oncology Medical Group, Inc., Alhambra

92024

Hematology-Encinitas, Encinitas

Scripps Clinic Encinitas, Encinitas

92037

Hematology-La Jolla, La Jolla

Sabina R. Wallach, MD., AMC, La Jolla

Scripps Cancer Center-San Diego, La Jolla

92056

North County Oncology Medical Clinic, Inc., Oceanside

92103

Peter T. Reissman, MD, Inc, San Diego

William Stanton, MD, Inc, San Diego

92120

Kaiser Permanente-San Diego, San Diego

92123

Sharp Rees-Stealy, San Diego

92128

Scripps Clinic-Rancho Bernardo, San Diego

92200

Clinique Hartmann, Neuilly-sur-Seine

92224

Klinikum St. Marien Amberg, Amberg

92335

Kaiser Permanente-Fontana, Fontana

92505

Kaiser Permanente-Riverside, Riverside

92618

Kaiser Permanente-Irvine, Irvine

92648

Pacific Shores Medical Group, Huntington Beach

92803

San Diego Pacific Oncology & Hematology-Vista, Vista

92807

Kaiser Permanente-Orange County, Panorama City

92835

St. Jude Heritage Healthcare, Fullerton

93105

Sansum Clinic, Santa Barbara

Santa Barbara Hematology Oncology Medical Group, Santa Barbara

93309

Comprehensive Blood and Cancer Center, Bakersfield

93454

Central Coast Medical Oncology Corporation, Santa Maria

93534

Antelope Valley Cancer Center, Lancaster

94000

Ch intercommunal de creteil, Créteil

94080

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94305

Stanford University Medical Center, Stanford

94545

Kaiser Permanente-Hayward, San Francisco

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

95051

Kaiser Permanente-Santa Clara, Santa Clara

95126

Humanitas Centro Catanese, Catania

95661

Kaiser Permanente-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95816

Sutter Medical Center, Sacramento

Sutter Medical Group, Sacramento

95825

Kaiser Permanente-Sacramento, Roseville

96813

Oncare Hawaii, Inc-POB2, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii, Honolulu

96817

Oncare Hawaii, Inc-KMP, Honolulu

97213

Northwest Cancer Specialists-Portland, Portland

Providence Portland Medical Center, Portland

97216

Adventist Medical Center, Portland

Northwest Cancer Specialists-Adventist Office, Portland

97225

CCOP, Columbia River Oncology, Portland

Providence Oncology and Hematology Care Clinic, Portland

Providence St. Vincent Medical Center, Portland

98004

Overlake Internal Medicine, Bellevue

98664

Southwest Washington Hospital, Vancouver

98684

Northwest Cancer Specialists-136th Ave, Vancouver

98686

Northwest Cancer Specialists-134th St., Vancouver

99204

Rockwood Cancer Treatment Center - Sinto Ave, Spokane

Rockwood Cancer Treatment Center, Spokane

100021

Chinese Academy of Medical Science, Beijing

100071

The Pla 307 Hospital, Beijing

100853

Chinese PLA General Hospital, Beijing

130012

Jilin Cancer Hospital, Changchun

300060

Tianjin Cancer Hospital, Tianjin

310003

1st Affiliated Hospital of Zhejiang University, Hangzhou

310022

Zhejiang Tumor Hospital, Hangzhou

354200

Fuzhou General Hospital of Nanjing Military Area, Fuzhou

510000

County Hospital Alba-Iulia, Alba Iulia

510060

Sun Yat-sen University Hospital, Guangzhou

610041

West China Hospital, Sichuan University, Chengdu

2820000

Hospital Regional Rancagua, Rancagua

06001

Oncology Associates P.C.-Avon, Avon

06606

Medical Specialists of SWIM, Bridgeport

06610

Bridgeport Hospital, Bridgeport

06824

Medical Specialists of Fairfield, Fairfield

Oncology Associates of Bridgeport-Fairfield, Fairfield

06102

Hartford Hospital, Hartford

06106

Connecticut Multi Specialty Group-Hartford, Hartford

Oncology Associates P.C.-Hartford, Hartford

06451

Medical Oncology and Hematology, P.C., Meriden

06360

Eastern Connecticut Hematology & Oncology Associates, Norwich

06611

Black Rock Medical Group, Trumbull

Oncology Associates of Bridgeport-Trumbull, Trumbull

06708

Medical Oncology & Hematology, P.C., Waterbury

06109

Connecticut Multi Specialty Group-Wethersfield, Wethersfield

06226

Oncology Associates P.C.-Willimantic, Willimantic

04401

Eastern Maine Medical Center, Bangor

01247

Berkshire Hematology Oncology, P.C.-North Adams, North Adams

01201

Berkshire Hematology Oncology, P.C., Pittsfield

07922

Summit Medical Group, Berkeley Heights

07631

Drs. Forte, Schleider, Attas and Condemi, PA, Englewood

08690

Cancer Institute of New Jersey at Hamilton, Hamilton

07740

Monmouth Medical Center, Long Branch

07960

Morristown Memorial Hospital, Morristown

08901

Cancer Institute of New Jersey, New Brunswick

07103-2425

University of Medicine and Dentistry of New Jersey, Newark

07112

Newark Beth Israel Medical Center, Newark

07871

Sparta Cancer Treatment Center, Sparta

07901

Overlook Hospital, Summit

17882-2170

Geisinger Clinic, Danville

19141-3098

Albert Einstein Healthcare Network, Philadelphia

26506-9162

West Virginia University Hospitals Inc., Morgantown

B1902CMV

Breast Clinica de la mama, La Plata

B1629ODT

Hospital Universitario Austral, Presidente Derqui

S2000DSK

Centro Oncologico Rosario (COR), Rosario

C1280AEB

Hospital Britanico de Buenos Aires, Buenos Aires

C1431FWO

CEMIC, Buenos Aires

A-8036

Medizinische Universitat Graz - Onkologie, Graz

A-6020

AI University Hospital Innsbruck, Innsbruck

74075-040

Centro Goiano de oncologia, Goiânia

30110-090

Lifecenter Sistema de Saude S/A, Belo Horizonte

20560-120

Instituto Nacional de Cancer, Rio de Janeiro

22260-020

Clinica Oncologistas Associados, Rio de Janeiro

98700-000

Assoiacao hospital de caridade de ijui, Ijuí

90035-003

Hospital Das Clinicas de Porto Alegre-HCPA, Porto Alegre

90050-170

Irmandade da Santa Casa de Misericoria de Porto Alegre Nucleo de Novos Tratamentos, Porto Alegre

90430-090

Clinica de Oncologia de Porto Alegre, Porto Alegre

17210-080

Fundacao Dr. Amaral Carvalho, Jaú

13419-155

Instituto de Oncologia Clinica de Piracicaba, Piracicaba

09060-650

Centro de Oncologia e Hematologia da Faculdade de Medicina do ABC, Santo André

01246-000

Instituto do Cancer de Sao Paulo, São Paulo

18030-075

Conjunto Hospitalar de Sorocaba, Sorocaba

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Dept of Medicine, Edmonton

V7L 2L7

Lion's Gate Hospital, North Vancouver

AIB 3V6

Dr. H. Bliss Murphy Cancer Centre, St. John's

L6R 3J7

William Osler Health Center, Brampton

L5M 2N1

Credit Valley Hospital, Mississauga

L3Y 2P9

Southlake Regional Health Centre, Newmarket

K1H 8L6

Ottawa Hospital Regional Cancer Centre, Ottawa

M5B 1W8

St. Michaels Hospital, Toronto

M9N 1N8

Humber River Regional Hospital, Weston

N8W 2X3

Windsor Regional Cancer Centre, Windsor

J4V 2H1

Hopital Charles LeMoyne, Greenfield Park

H1T 2M4

Hopital Maisonneuve Rosemont, Montreal

H3A 1A1

Royal Victoria Hospital, Montreal

H3G 1A4

Montreal General Hospital, Montreal

H3T 1E2

Jewish General Hospital, Montreal

H4J 1C5

Hospital du Sacre-Coeur, Montreal

Unknown

University of Montreal Hospital Group, Montreal

Prince of Wales Hospital, Hong Kong

Queen Elizabeth Hospital, Hong Kong

Petz Aladar Megyei Oktato, Győr

Cork University Hospital, Cork

Adelaide and Meath National Childrens Hospital, Dublin

Institute for Cancer Research, Dublin

Mater Private Hospital, Dublin

St. Vincent's University Hospital, Dublin

University College Hospital Galway, Galway

Midwestern Regional Hospital, Limerick

Sligo General Hospital, Sligo

The Lady Davis Carmel Medical Center/Lynn, Haifa

Kaplan Medical Center, Rehovot

Ziv Medical Center, Safed

Sourasky (Ichilov) Medical Center, Tel Aviv

Assaf Harofeh Medical Center, Ẕerifin

Ospedale vito fazzi, Lecce

Ospedale di Mirano, Mirano

Regina Elena Cancer Institute, Rome

Ospedale casa sollievo della sofferenza, San Giovanni

Asl n. 5 -Ospedale s. Vincenzo, Taormina

P. Stradina Clinical University Hospital, Riga

Hospital Nacional Carlos Alberto Seguin, Arequipa

Regional Oncology Center, Bialystok

"Institutul Oncologic Prof. Dr. I. Chiricuta Cluj-Napoca", Cluj-Napoca

"State Medical Institution Republican Clinical Oncology Dispensary Ministry of Health of Republic Tatarstan", Kazan'

"State Institution Russian Oncological Research Center n.a. N.N. Blokhin of RAMS", Moscow

"Federal State Institution Research Institute of Oncology n.a. N.N. Petrov Rosmedtechnologiy", Saint Petersburg

"Saint-Petersburg State Medical Institution City Clinical Oncology Dispensary", Saint Petersburg

Johannesburg Hospital, Johannesburg

Instituto Oncologico de Guipuzcoa, Donostia / San Sebastian

Hospital Xera Calde, Lugo

Hospital Santa Maria Nai Dr. Cabaleiro, Ourense

Songklanagarind Hospital, Songkhla

G1S 4L8

Centre Hospitalier Affilie Universitaire De Quebec, Hospital du St-Sacrement, Québec

180 81

FN Na Bulovce, Prague

09116

Klinikum Chemnitz, Chemnitz

01307

Universitaetsklinikum Dresden, Dresden

D-60590

Zentrum fur Frauenheilkunde und Geburtshilfe, Frankfurt

07743

Universitat Frauenklinik Jena, Jena

D-32657

Klinikum Lippe Lemgo, Lemgo

D-39576

Johanniter Krankenhaus, Stendal

H-7400

Kaposi Mor oktato korhaz Onkologiai tanszek, Kaposvár

0009

Beaumont Hospital, Dublin

00135

Ospedale S. Filippo Neri, Roma

07100

Universita-istituto Clinica Medica, Sassari

Lima 11

Hospital Nacional Edgardo Rebagliati Martins, Lima

44-101

Centrum Onkologii Instytut im. M., Gliwice

10-228

ZOZ MSWiA z Warminsko-Mazurskim Centrum, Olsztyn

10-513

"Olsztynski Osrodek Onkologiczny Kopernik", Olsztyn

44-200

Samodzielny Publiczny Zaklad Opieki, Rybnik

02-781

Breast Cancer Clinic, Warsaw

3000-073

HUC, Coimbra

4200-319

IPO Francisco Gentil-Porto, Porto

022338

"Institute of Oncology AI.Trestioreanu", Bucharest

463-707

Seoul National University Bundang Hospital, Gyeonggi-do

110-744

Seoul National University Hospital, Seoul

120-752

Severance Hospital, Seoul

135-710

Samsung Medical Center, Seoul

138-736

Asan Medical Center, Seoul

03010

Hospital General de Alicante, Alicante

08916

Hospital Germans Trias l Pujol, Badalona (Barcelona)

08003

Hospital Del Mar, Barcelona

08025

Hospital Santa Crue l San Pau, Barcelona

08036

Hospital Clinic i Provincial, Barcelona

08227

Consorci Sanitari de Terrassa, Barcelona

08243

Althaia Xarxa Assistencial de Manresa, Barcelona

08923

Hospital Espiritu Santo, Barcelona

03202

Hospital Gral. De Elche, Elche

08208

Hospital del Parc Tauli, Sabadell

03186

Hospital Torrevieja Salud, UTE, Torrevieja

S-118

Karolinska University Hospital, Stockholm

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

BS2 8ED

Bristol Hematology - Oncology Centre, Bristol

IP4 5PD

Ipswich Hospital, Ipswich

M20 4BX

Christie Hospital NHS Trust, Manchester

NG5 1PB

Nottingham City Hospital, Nottingham

PE3 6DA

Peterborough District Hospital, Peterborough

TR1 3IJ

Sunrise Cancer Centre, Truro

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Cancer International Research Group (CIRG)

OTHER

collaborator

Hoffmann-La Roche

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

lead

NSABP Foundation Inc

NETWORK

NCT00625898 - BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab | Biotech Hunter | Biotech Hunter