Comparative Study of Ceftaroline vs. Ceftriaxone in Adult Subjects With Community-Acquired Pneumonia

PHASE3CompletedINTERVENTIONAL
Enrollment

606

Participants

Timeline

Start Date

January 31, 2008

Primary Completion Date

December 31, 2008

Study Completion Date

June 30, 2009

Conditions
Bacterial Pneumonia
Interventions
DRUG

Ceftaroline fosamil for Injection

2 consecutive, 300 mg dose parenteral infused over 30 minutes, every 12 hours, for 5 to 7 days

DRUG

IV Ceftriaxone

1 g dose parenteral infused over 30 minutes, every 24 hours, for 5 to 7 days

DRUG

Placebo

Subjects randomized to receive ceftriaxone will receive ceftriaxone at a dose of 1 g infused over 30 minutes followed by IV saline placebo infused over 30 minutes, every 24 hours (q24h). Twelve hours after each dose of ceftriaxone and saline placebo (ie, between ceftriaxone doses), subjects in this group will receive two consecutive saline placebo infusions, each infused over 30 minutes q24h. The ceftriaxone and saline placebo infusions will correspond to the q12h infusions of ceftaroline, thereby maintaining the blind

DRUG

Clarithromycin

In both treatment groups, two doses of oral clarithromycin (500 mg q12h), defined as adjunctive therapy, were initiated on Study Day 1 with study drug therapy in order to provide an immunomodulatory benefit and initial therapy for possible infection due to an atypical organism.

Trial Locations (168)

1125

Investigational Site, Budapest

1211

Investigational Site, Geneva

1431

Investigational Site, Sofia

1500

Investigational Site, Benomi

1602

Investigational Site, Vicente López

1650

Investigational Site, Buenos Aires

1748

Investigational Site, Buenos Aires

1752

Investigational Site, Krugersdorp

2045

Investigational Site, Törökbálint

2300

Investigational Site, La Chaux-de-Fonds

2501

Investigational Site, Biel

2800

Investigational Site, Tatabánya

Investigational Site, Tatabánya

3233

Investigational Site, Mátraháza

3529

Investigational Site, Miskolc

6020

Investigational Site, Port Elizabeth

6850

Investigational Site, Worcester

7130

Investigational Site, Somerset West

7505

Investigational Site, Cape Town

7530

Investigational Site, Bellville

Investigational Site, Cape Town

7623

Investigational Site, Pécs

8000

Investigational Site, Burgas

9010

Investigational Site, Varna

9400

Investigational Site, Sopron

10110

Investigational Site, Bangkok

10138

Investigational Site, Tallinn

10400

Investigational Site, Bangkok

InvestigationalSite, Bangkok

10700

Investigational Site, Bangkok

10990

Investigational Site, George Town

11000

Investigational Site, Nonthaburi

11080

Investigational Site, Belgrade

13125

Investigational Site, Lindenberger

13353

Investigational Site, Berlin

13419

Investigational Site, Tallinn

18204

Investigational Site, Knez-Selo

21237

Investigational Site, Baltimore

23538

Investigational Site, Lübeck

24411

Investigational Site, León

28007

Investigational Site, Madrid

30905

Investigational Site, Fort Gordon

32806

Investigational Site, Orlando

33098

Investigational Site, Paderborn

34000

Investigational Site, Kragujevac

36038

Investigational Site, Poltava

40002

Investigational Site, Khonkaen

44305

Investigational Site, Akron

44793

Investigational Site, Bochum

44879

Investigational Site, Bochum

46009

Investigational Site, Valencia

48960

Investigational Site, Vizcaya

49074

Investigational Site, Dnipropetrovsk

49102

Investigational Site, Dnipropetrovsk

50200

Investigational Site, Chiang Mai

50590

Investigational Site, Kuala Lumpur

51014

Investigational Site, Tartu

53545

Investigational Site, Lich

55422

Investigational site, Minneapolis

58515

Investigational Site, Lüdenscheid

59701

Investigational Site, Butte

61018

Investigational Site, Kharkiv

61035

Investigational Site, Kharkiv

61603

Investigational Site, Peoria

64646

Investigational Site, Heppenheim an der Bergstrasse

65025

Investigational Site, Odesa

65199

Investigational Site, Wiesbaden

74000

Investigational Site, Annecy

75475

Investigational Site, Paris

75674

Investigational Site, Paris

76025

Investigational Site, Ivano-Frankivsk

77030

Investigational Site, Houston

79013

Investigational Site, Aviv

80100

Investigational Site, Johor Bahru

83099

Investigational Site, Donetsk

88015

Investigational Site, Uzhhorod

89081

Investigational Site, Ulm

90015

Investigational site, Los Angeles

91045

Investigational Site, Luhansk

91105

Investigational Site, Pasadena

92114

Investigational Site, San Diego

95100

Investigational Site, Argenteuil

95817

Investigational Site, Sacramento

99089

Investigational Site, Erfurt

119048

Investigational Site, Moscow

123182

Investigational Site, Moscow

125206

Investigational Site, Moscow

163045

Investigational Site, Arkhangelsk

185014

Investigational Site, Petrozavodsk

191104

Investigational Site, Saint Petersburg

194354

Investigational Site, Saint Petersburg

195257

Investigational Site, Saint Petersburg

344010

Investigational Site, Rostov-on-Don

400238

Investigational Site, Cluj-Napoca

410176

Investigational Site, Oradea

540136

Investigational Site, Târgu Mureş

620109

Investigational Site, Yekaterinburg

620137

Investigational Site, Yekaterinburg

632004

Investigational Site, Vellore

750120

Investigational Site, Paris

C1431FWO

Investigational Site, Buenos Aires

T4000IIH

Investigational Site, San Miguel de Tucumán

B1702FWM

Investigational Site, Buenos Aires

B6700AQJ

Investigational Site, Buenos Aires

C1155ADP

Investigational Site, Buenos Aires

C1430BKC

Investigational Site, Buenos Aires

C1437 BZK

Investigational Site, Buenos Aires

A-1030

Investigational Site, Vienna

A-1090

Investigational Site, Vienna

74465-539

Investigational Site, Goiânia

90020-090

Investigational Site, Porto Alegre

90610-001

Investigational Site, Porto Alegre

15090-000

Investigational Site, São José do Rio Preto

30140-062

Investigational Site 2, Belo Horizonte

30150-221

Investigational Site 1, Belo Horizonte MG

SP 13059-900

Investigational Site, Campinas

80810-040

Investigational Site, Curitiba-PR

36036-110

Investigational Site, Juiz de Fora

90035-001

Investigational site, Porto Alegre

04038-905

Investigational Site, São Paulo

17201-340

Investigational Site, São Paulo

0144

Investigational Site, Tbilisi

0160

Investigational Site, Tbilisi

04435

Investigational Site, Schkeuditz

LT-45130

Investigational Site, Kaunas

LT-50009

Investigational Site, Kaunas

LT-92231

Investigational Site, Klaipėda

LT-92288

Investigational Site, Klaipėda

LT-76231

Investigational Site, Šiauliai

LT-10207

Investigational Site, Vilnius

05460

Inestigational Site, Cheras

Investigational Site, Kedah

42-500

Investigational Site, Będzin

32-800

Investigational Site, Brzesku

41-902

Investigational Site, Bytom

64-800

Investigational Site, Chodzież

42-200

Investigational Site, Częstochowa

40-635

Investigational Site, Katowice-Ochojec

30-053

Investigational Site, Krakow

20-178

Investigational Site, Lublin

20-718

Investigational Site, Lublin

60-479

Investigational Site, Poznan

60-569

Investigational Site, Poznan

43-100

Investigational Site, Tychy

01-138

Investigational Site, Warsaw

03-401

Investigational Site, Warsaw

03-737

Investigational Site, Warsaw

127 02-507

Investigational Site, Warsaw

53-439

Investigational Site, Wroclaw

042122

Inestigational Site, Bucharest

050098

Investigational Site, Bucharest

Unknown

Investigational Site, Constanța

Investigational Site, Timișoara

25-27

Investigational Site, Saint Brasov

410-002

Investigational Site, Saratov

420-101

Investigational Site, Tatarstan

813 69

Investigational Site, Bratislava

948 88

Slovakia, Nitra-Zobor

0001

Investigational Site, Pretoria

0084

Investigational Site, Pretoria

0140

Investigational Site, Pretoria

0188

Investigational Site, Pretoria

08035

Investigational Site, Barcelona

08036

Investigational Site, Barcelona

03203

Investigational Site, Elche

46,6903

Investigational Site, Lugano

02091

Inestigational Site, Kyiv

03680

Investigational Site, Kyiv

Sponsors
All Listed Sponsors
lead

Forest Laboratories

INDUSTRY