24
Participants
Start Date
April 30, 2007
Primary Completion Date
June 30, 2007
Study Completion Date
June 30, 2007
1 tablet Ezetrol(R) (ezetimibe), MSD Sharp & Dohme GmbH, Germany
administration of 1 tablet Ezetrol(R) (10 mg ezetimibe), 0-144 h blood sampling, 0-5 d urine sampling (24 h intervals) and 0-10 d feces sampling
1 tablet Rapamune(R) (sirolimus), Wyeth Pharma, Germany
administration of 5 ml Rapamune(R) oral solution (1 mg/ml sirolimus), 0-144 h blood sampling
1 tablet Ezetrol(R) + 1 tablet Rapamune(R)
administration of 1 tablet Ezetrol(R) (10 mg ezetimibe) and 5 ml Rapamune(R) oral solution (1 mg/ml sirolimus), 0-144 h blood sampling, 0-5 d urine sampling (24 h intervals) and 0-10 d feces sampling
Department of Clinical Pharmacology, Greifswald
University Medicine Greifswald
OTHER