Carboplatin, Docetaxel, Bevacizumab, and Erlotinib Versus Chemotherapy Alone in Resected NSCLC

PHASE2CompletedINTERVENTIONAL
Enrollment

112

Participants

Timeline

Start Date

December 31, 2007

Primary Completion Date

July 31, 2013

Study Completion Date

February 28, 2014

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Docetaxel/Carboplatin/Bevacizumab/Erlotinib

"Docetaxel 75mg/m2 IV D1 Carboplatin AUC=6 IV D1 Bevacizumab 15mg/kg IV D1~Docetaxel should be administered before carboplatin.~After completion of four cycles of treatment, patients in Cohort A will then proceed with Maintenance treatment defined as follows:~Maintenance Treatment for patients in Cohort A:~Bevacizumab 15mg/kg IV D1 Erlotinib 150mg PO daily~Treatment cycle = 21 days. Patients will complete 8 cycles (24 weeks) of maintenance therapy unless there is evidence of disease recurrence or unacceptable toxicity."

DRUG

Docetaxel/Carboplatin

"Adjuvant Treatment Cohort B:~Docetaxel 75mg/m2 IV D1 Carboplatin AUC=6 IV D1~Docetaxel should be administered before carboplatin.~Treatment cycle = 21 days. Patients in Cohort B will complete 4 cycles of treatment."

Trial Locations (26)

20817

Center for Cancer and Blood Disorders, Bethesda

23601

Peninsula Cancer Institute, Newport News

28801

Cancer Care of Western North Carolina, Asheville

30060

Wellstar Cancer Research, Marietta

30501

Northeast Georgia Medical Center, Gainesville

30901

Medical Oncology Associates of Augusta, Augusta

33705

Gulfcoast Oncology Associates, St. Petersburg

33901

Florida Cancer Specialists, Fort Myers

36207

Northeast Alabama Medical Center, Anniston

37023

Tennessee Oncology, PLLC, Nashville

37404

Associates in Hematology Oncology, Chattanooga

Chattanooga Oncology Hematology Associates, Chattanooga

39202

Jackson Oncology Associates, Jackson

40207

Baptist Hospital East, Louisville

Norton Cancer Institute, Louisville

45242

Oncology Hematology Care, Cincinnati

47802

Providence Medical Group, Terre Haute

RHHP/Hope Cancer Center, Terre Haute

63017

St. Louis Cancer Care, Chesterfield

68114

Nebraska Methodist Cancer Center, Omaha

70806

Hematology Oncology Clinic, LLP, Baton Rouge

71301

Hematology Oncology Life Center, Alexandria

72401

Northeast Arkansas Clinic, Jonesboro

87109

New Mexico Oncology Hematology Consultants, Albuquerque

03801

Portsmouth Regional Hospital, Portsmouth

07960

Hematology Oncology Associates of Northern NJ, Morristown

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Sanofi

INDUSTRY

lead

SCRI Development Innovations, LLC

OTHER