Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention

PHASE4CompletedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

September 30, 2009

Study Completion Date

September 30, 2009

Conditions
Traumatic Brain InjurySubarachnoid Hemorrhage
Interventions
DRUG

Levetiracetam

Levetiracetam group will receive a loading dose of 20 mg/kg IV(rounded to nearest 250mg) to a maximum of 2000mg, then started on maintenance dose (1000 mg,IV q 12h) as prophylaxis for seven days.

DRUG

Phenytoin

The group will receive a loading dose of fosphenytoin 20 mg/kg IV to a maximum of 2000 mg, then started on maintenance dose of 5mg/kg/day, rounded to nearest 100mg dose, IV, q 12h for seven days.

Trial Locations (1)

45220

University of Cincinnati Hospital, Cincinnati

All Listed Sponsors
collaborator

Mayfield Clinic & Spine Institute

OTHER

lead

University of Cincinnati

OTHER

NCT00618436 - Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention | Biotech Hunter | Biotech Hunter