79
Participants
Start Date
April 30, 2008
Primary Completion Date
January 31, 2010
Study Completion Date
December 31, 2016
capecitabine
1650 mg/m\^2/day orally 5 days/week during radiotherapy.
oxaliplatin
resection
All patients undergo surgery 4 to 8 weeks following the completion of radiation therapy. The choice of procedure (abdominoperineal resection (APR), low anterior resection (LAR), or LAR/coloanal anastomosis) is at the discretion of the surgeon.
radiation therapy
Pelvic intensity modulated radiation therapy (IMRT): 45 Gy in 25 fx Three dimensional conformal radiation therapy (3D-CRT) boost: 5.4 Gy in 3 fx to total dose of 50.4 Gy in 28 fx
FOLFOX
"Postoperative chemotherapy is administered to all patients who have a complete resection of rectal cancer with negative surgical margins and begins within 4-8 weeks following surgical resection, consisting of a total of 9 14-day cycles. Oxaliplatin 85 mg/m\^2, IV over 2 hours, day 1.~Leucovorin 400 mg/m\^2, IV over 2 hours, day 1. 5-fluorouracil bolus 400 mg/m\^2, IV push, day 1. 5-fluorouracil infusion 2400 mg/m\^2, IV continuous infusion over 46 hours, day 1."
CCOP - North Shore University Hospital, Manhasset
Don Monti Comprehensive Cancer Center at North Shore University Hospital, Manhasset
Long Island Jewish Medical Center, New Hyde Park
Monter Cancer Center of the North Shore-LIJ Health System, Lake Success
Maimonides Cancer Center at Maimonides Medical Center, Brooklyn
Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg
Upper Delaware Valley Cancer Center, Milford
Northeast Radiation Oncology Center, Dunmore
Rosenfeld Cancer Center at Abington Memorial Hospital, Abington
Bryn Mawr Hospital, Bryn Mawr
Riddle Memorial Hospital Cancer Center, Media
CCOP - Main Line Health, Wynnewood
Lankenau Cancer Center at Lankenau Hospital, Wynnewood
Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
University of Virginia Cancer Center, Charlottesville
Southwest Virginia Regional Cancer Center at Wellmonth Health, Norton
Wayne Memorial Hospital, Incorporated, Goldsboro
Wayne Radiation Oncology, Goldsboro
Hollings Cancer Center at Medical University of South Carolina, Charleston
Piedmont Hospital, Atlanta
John B. Amos Cancer Center, Columbus
Integrated Community Oncology Network - Orange Park, Orange Park
Baptist Cancer Institute - Jacksonville, Jacksonville
Bay Medical, Panama City
Baptist-South Miami Regional Cancer Program, Miami
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus, Boca Raton
Providence Cancer Center at Providence Hospital, Mobile
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport
Regional Cancer Center at Singing River Hospital, Pascagoula
Barberton Citizens Hospital, Barberton
Cancer Care Center, Incorporated, Salem
Cancer Treatment Center, Wooster
Precision Radiotherapy at University Pointe, West Chester
Charles M. Barrett Cancer Center at University Hospital, Cincinnati
Saint John's Cancer Center at Saint John's Medical Center, Anderson
St. Vincent Oncology Center, Indianapolis
Center for Cancer Care at Goshen General Hospital, Goshen
Columbia Saint Mary's Hospital - Ozaukee, Mequon
Columbia-Saint Mary's Cancer Care Center, Milwaukee
Medical College of Wisconsin Cancer Center, Milwaukee
United Hospital, Saint Paul
Minnesota Oncology Hematology, PA - Maplewood, Maplewood
Minnesota Oncology Hematology, PA - Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
St. Francis Cancer Center at St. Francis Medical Center, Shakopee
Ridgeview Medical Center, Waconia
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis
CCOP - Metro-Minnesota, Saint Louis Park
Park Nicollet Cancer Center, Saint Louis Park
Mercy and Unity Cancer Center at Unity Hospital, Fridley
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Cancer Institute at St. John's Hospital, Springfield
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis
Barnes-Jewish West County Hospital, St Louis
Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters, City of Saint Peters
Cancer Institute of Cape Girardeau, LLC, Cape Girardeau
Liberty Hospital, Liberty
Saint Luke's East - Lee's Summit, Lee's Summit
Truman Medical Center - Hospital Hill, Kansas City
Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City
St. Joseph Medical Center, Kansas City
North Kansas City Hospital, Kansas City
Parvin Radiation Oncology, Kansas City
CCOP - Kansas City, Kansas City
Research Medical Center, Kansas City
Heartland Regional Medical Center, Saint Joseph
CCOP - Cancer Research for the Ozarks, Springfield
Hulston Cancer Center at Cox Medical Center South, Springfield
Shawnee Mission Medical Center, Shawnee Mission
Menorah Medical Center, Overland Park
Saint Luke's Hospital - South, Overland Park
Nebraska Medical Center, Omaha
Oklahoma University Cancer Institute, Oklahoma City
Integris Oncology Services, Oklahoma City
American Fork Hospital, American Fork
LDS Hospital, Salt Lake City
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center - Provo, Provo
Sandra L. Maxwell Cancer Center, Cedar City
Dixie Regional Medical Center - East Campus, St. George
University Medical Center of Southern Nevada, Las Vegas
CCOP - Nevada Cancer Research Foundation, Las Vegas
Renown Institute for Cancer at Renown Regional Medical Center, Reno
Veterans Affairs Medical Center - San Diego, San Diego
California Cancer Center - Woodward Park Office, Fresno
Auburn Radiation Oncology, Auburn
Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael
Radiation Oncology Center - Roseville, Roseville
Radiation Oncology Centers - Cameron Park, Cameron Park
Solano Radiation Oncology Center, Vacaville
Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento
Mercy General Hospital, Sacramento
City of Hope Comprehensive Cancer Center, Duarte
Rebecca and John Moores UCSD Cancer Center, La Jolla
University of Florida Shands Cancer Center, Gainesville
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah
Cancer Center at Ball Memorial Hospital, Muncie
Massachusetts General Hospital, Boston
Dana-Farber/Brigham and Women's Cancer Center, Boston
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston
Boston University Cancer Research Center, Boston
Hudner Oncology Center at Saint Anne's Hospital - Fall River, Fall River
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale
Kingsbury Center for Cancer Care at Cheshire Medical Center, Keene
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Monmouth Medical Center, Long Branch
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton
J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River
Summa Center for Cancer Care at Akron City Hospital, Akron
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey
Cancer Center of Paoli Memorial Hospital, Paoli
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia
Rhode Island Hospital Comprehensive Cancer Center, Providence
Norris Cotton Cancer Center - North, Saint Johnsbury
London Regional Cancer Program at London Health Sciences Centre, London
Collaborators (1)
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK