Bevacizumab and Temsirolimus in Patients With Advanced Malignancy

PHASE1CompletedINTERVENTIONAL
Enrollment

193

Participants

Timeline

Start Date

January 25, 2008

Primary Completion Date

November 28, 2017

Study Completion Date

November 28, 2017

Conditions
Advanced Cancer
Interventions
DRUG

Bevacizumab

5 mg/kg By Vein Over 90 Minutes on Day 1 of Each 21 Day Cycle

DRUG

Temsirolimus

5 mg By Vein Over 30-60 Minutes on Days 1, 8, 15 of Each 21 Day Cycle

PROCEDURE

Additional Blood Drawn

2 teaspoons each time: 4xDay Cycle 1 after start of first infusion; at Day 8 of Cycle 1; at Day 15 of Cycle 1; and at end of Cycle 1.

PROCEDURE

Biopsy

First tumor biopsy during screening visit and Second at the end of Cycle 1

PROCEDURE

DCE-MRI Scan

DCE-MRI (dynamic contrast-enhanced magnetic resonance imaging) scan during screening visit, at 24-48 hours after the start of Cycle 1, and at the end of Cycle 1

Trial Locations (1)

77030

University of Texas MD Anderson Cancer Center, Houston

All Listed Sponsors
lead

M.D. Anderson Cancer Center

OTHER

NCT00610493 - Bevacizumab and Temsirolimus in Patients With Advanced Malignancy | Biotech Hunter | Biotech Hunter