193
Participants
Start Date
January 25, 2008
Primary Completion Date
November 28, 2017
Study Completion Date
November 28, 2017
Bevacizumab
5 mg/kg By Vein Over 90 Minutes on Day 1 of Each 21 Day Cycle
Temsirolimus
5 mg By Vein Over 30-60 Minutes on Days 1, 8, 15 of Each 21 Day Cycle
Additional Blood Drawn
2 teaspoons each time: 4xDay Cycle 1 after start of first infusion; at Day 8 of Cycle 1; at Day 15 of Cycle 1; and at end of Cycle 1.
Biopsy
First tumor biopsy during screening visit and Second at the end of Cycle 1
DCE-MRI Scan
DCE-MRI (dynamic contrast-enhanced magnetic resonance imaging) scan during screening visit, at 24-48 hours after the start of Cycle 1, and at the end of Cycle 1
University of Texas MD Anderson Cancer Center, Houston
M.D. Anderson Cancer Center
OTHER