Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

June 30, 2006

Primary Completion Date

December 31, 2009

Study Completion Date

January 31, 2013

Conditions
Lymphoma
Interventions
DRUG

chlorambucil

DRUG

fludarabine phosphate

PROCEDURE

quality-of-life assessment

Trial Locations (49)

2298

Newcastle Mater Misericordiae Hospital, Waratah

2605

Canberra Hospital, Garran

3002

Peter MacCallum Cancer Centre, East Melbourne

4102

Princess Alexandra Hospital, Brisbane

5011

Queen Elizabeth Hospital, Woodville

HP21 8AL

Stoke Mandeville Hospital, Aylesbury-Buckinghamshire

EX31 4JB

North Devon District Hospital, Barnstaple

RG24 9NA

Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke

BA1 3NG

Royal United Hospital, Bath

B18 7QH

City Hospital - Birmingham, Birmingham

B9 5SS

Birmingham Heartlands Hospital, Birmingham

FY3 8NR

Blackpool Victoria Hospital, Blackpool

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

BD9 6RJ

Bradford Royal Infirmary, Bradford

DE13 0RB

Queen's Hospital, Burton-on-Trent

GL53 7AN

Gloucestershire Oncology Centre at Cheltenham General Hospital, Cheltenham

P019 4SE

Saint Richards Hospital, Chichester

DN2 5LT

Doncaster Royal Infirmary, Doncaster

DY1 2HQ

Russells Hall Hospital, Dudley

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

GL1 3NN

Gloucestershire Royal Hospital, Gloucester

HG2 7SX

Harrogate District Hospital, Harrogate

HR1 2ER

Hereford Hospitals, Hereford

WD18 0HB

Watford General Hospital, Herts

Unknown

Wycombe General Hospital, High Wycombe

HU3 2KZ

Hull Royal Infirmary, Hull

PE30 4ET

Queen Elizabeth Hospital, Kings Lynn

LS1 3EX

Leeds General Infirmary, Leeds

EC1A 7BE

Saint Bartholomew's Hospital, London

WC1E 6AU

University College Hospital - London, London

M27 4HA

Royal Manchester Children's Hospital, Manchester

M31 3SL

Trafford General Hospital, Manchester

0X3 9DU

Oxford Radcliffe Hospital, Oxford

PL6 8DH

Derriford Hospital, Plymouth

WF8 1PL

Pontefract General Infirmary, Pontefract West Yorkshire

RG1 5AN

Berkshire Cancer Centre at Royal Berkshire Hospital, Reading

S60 2UD

Rotherham General Hospital, Rotherham

SL2 4HL

Wexham Park Hospital, Slough, Berkshire

ST16 3SA

Staffordshire General Hospital, Stafford

TA1 5DA

Taunton and Somerset Hospital, Taunton Somerset

TQ2 7AA

Torbay Hospital, Torquay

TR1 3LJ

Royal Cornwall Hospital, Truro, Cornwall

TN4 8AT

Kent and Sussex Hospital, Tunbridge Wells, Kent

B71 4HJ

Sandwell General Hospital, West Bromwich

WV10 0QP

New Cross Hospital, Wolverhampton

ML6 0JF

Monklands General Hospital, Airdrie

G51 4TF

Southern General Hospital, Glasgow

WF1 4DG

Pinderfields General Hospital, Wakefield

LL57 2PW

Ysbyty Gwynedd, Bangor

All Listed Sponsors
lead

Taunton and Somerset Hospital

OTHER

NCT00608374 - Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic Lymphoma | Biotech Hunter | Biotech Hunter