Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

NACompletedINTERVENTIONAL
Enrollment

155

Participants

Timeline

Start Date

March 31, 2007

Primary Completion Date

October 25, 2012

Study Completion Date

October 25, 2012

Conditions
Arterial StiffeningAgingMenopause
Interventions
DRUG

GnRHant - Ganirelix acetate

1 subcutaneous injection at 0.5 mg then daily injections of 0.25 mg for 6 days (total of 7 days of injections); testing will occur on injection day 4 and day 7

DRUG

Transdermal estradiol patch

0.075mg/d starting on day 4 of the injections following testing time point two; continue for 3 days and retest (day 7)

DRUG

Transdermal placebo patch

Starting on day 4 of the injections following testing time point two; continue for 3 days and retest (day 7)

Trial Locations (1)

80045

University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory, Aurora

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

lead

University of Colorado, Denver

OTHER

NCT00608062 - Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women | Biotech Hunter | Biotech Hunter