Fludarabine and Rituximab With or Without Lenalidomide or Cyclophosphamide in Treating Patients With Symptomatic Chronic Lymphocytic Leukemia

PHASE2CompletedINTERVENTIONAL
Enrollment

418

Participants

Timeline

Start Date

January 15, 2008

Primary Completion Date

December 1, 2014

Study Completion Date

April 15, 2023

Conditions
Stage I Chronic Lymphocytic LeukemiaStage II Chronic Lymphocytic LeukemiaStage III Chronic Lymphocytic LeukemiaStage IV Chronic Lymphocytic Leukemia
Interventions
DRUG

Cyclophosphamide

Given IV

DRUG

Fludarabine Phosphate

Given IV or PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Lenalidomide

Given PO

BIOLOGICAL

Rituximab

Given IV

Trial Locations (364)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10029

Mount Sinai Hospital, New York

10065

NYP/Weill Cornell Medical Center, New York

10461

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

11030

North Shore University Hospital, Manhasset

11040

Long Island Jewish Medical Center, New Hyde Park

11042

Northwell Health NCORP, Lake Success

Northwell Health/Center for Advanced Medicine, Lake Success

11794

Stony Brook University Medical Center, Stony Brook

13057

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse

13210

State University of New York Upstate Medical University, Syracuse

14642

University of Rochester, Rochester

16801

Geisinger Medical Group, State College

16803

Mount Nittany Medical Center, State College

17044

Lewistown Hospital, Lewistown

17822

Geisinger Medical Center, Danville

18042

Easton Hospital, Easton

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18765

Geisinger South Wilkes-Barre, Wilkes-Barre

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Medical Center, Wynnewood

Main Line Health NCORP, Wynnewood

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19464

Pottstown Hospital, Pottstown

19718

Christiana Care Health System-Christiana Hospital, Newark

19958

Beebe Medical Center, Lewes

20007

MedStar Georgetown University Hospital, Washington D.C.

20016

Sibley Memorial Hospital, Washington D.C.

20852

Unspecified Site, Rockville

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21921

Christiana Care - Union Hospital, Elkton

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

24115

Sovah Health Martinsville, Martinsville

24541

Danville Regional Medical Center, Danville

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27203

Randolph Hospital, Asheboro

27320

Annie Penn Memorial Hospital, Reidsville

27403

Cone Health Cancer Center, Greensboro

27534

Wayne Memorial Hospital, Goldsboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27834

East Carolina University, Greenville

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28501

Vidant Oncology-Kinston, Kinston

28677

Iredell Memorial Hospital, Statesville

28791

Margaret R Pardee Memorial Hospital, Hendersonville

28801

Mission Hospital, Asheville

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29425

Medical University of South Carolina, Charleston

29506

McLeod Regional Medical Center, Florence

29601

Greenville Health System Cancer Institute-Andrews, Greenville

Saint Francis Hospital, Greenville

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29646

Self Regional Healthcare, Greenwood

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

32806

Orlando Health Cancer Institute, Orlando

33140

Mount Sinai Medical Center, Miami Beach

33458

Jupiter Medical Center, Jupiter

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37916

Thompson Cancer Survival Center, Knoxville

40215

Doctors Carrol, Sheth, Raghavan, Louisville

43015

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

Grant Medical Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43311

Mary Rutan Hospital, Bellefontaine

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

44710

Aultman Health Foundation, Canton

45177

Clinton Memorial Hospital, Wilmington

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45385

Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Dayton NCI Community Oncology Research Program, Dayton

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45750

Marietta Memorial Hospital, Marietta

45840

Blanchard Valley Hospital, Findlay

46107

Franciscan Saint Francis Health-Beech Grove, Beech Grove

46350

IU Health La Porte Hospital, La Porte

46360

Franciscan Saint Anthony Health-Michigan City, Michigan City

46391

Michiana Hematology Oncology PC-Westville, Westville

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46515

Elkhart General Hospital, Elkhart

46545

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46563

Michiana Hematology Oncology PC-Plymouth, Plymouth

46601

Memorial Hospital of South Bend, South Bend

Michiana Hematology Oncology PC-South Bend, South Bend

46617

South Bend Clinic, South Bend

46628

Northern Indiana Cancer Research Consortium, South Bend

46845

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne

46904

Community Howard Regional Health, Kokomo

47374

Reid Health, Richmond

48202

Henry Ford Hospital, Detroit

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49048

Borgess Medical Center, Kalamazoo

49085

Lakeland Medical Center Saint Joseph, Saint Joseph

Marie Yeager Cancer Center, Saint Joseph

49120

Lakeland Hospital Niles, Niles

49503

Cancer Research Consortium of West Michigan NCORP, Grand Rapids

49684

Munson Medical Center, Traverse City

49801

Green Bay Oncology - Iron Mountain, Iron Mountain

49829

Green Bay Oncology - Escanaba, Escanaba

50010

McFarland Clinic PC - Ames, Ames

50307

Mercy Capitol, Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Iowa-Wide Oncology Research Coalition NCORP, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

Mission Cancer and Blood - Laurel, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

51101

Siouxland Regional Cancer Center, Sioux City

51102

Mercy Medical Center-Sioux City, Sioux City

51104

Saint Luke's Regional Medical Center, Sioux City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52246

Iowa City VA Healthcare System, Iowa City

52501

Ottumwa Regional Health Center, Ottumwa

53038

UW Cancer Center Johnson Creek, Johnson Creek

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53081

HSHS Saint Nicholas Hospital, Sheboygan

53188

ProHealth Waukesha Memorial Hospital, Waukesha

53792

University of Wisconsin Carbone Cancer Center, Madison

54143

Bay Area Medical Center, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54235

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54449

Marshfield Medical Center-Marshfield, Marshfield

Marshfield Medical Center, Marshfield

54476

Diagnostic and Treatment Center, Weston

Marshfield Medical Center - Weston, Weston

54481

Ascension Saint Michael's Hospital, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54501

Ascension Saint Mary's Hospital, Rhinelander

Saint Mary's Hospital, Rhinelander

54548

Marshfield Clinic-Minocqua Center, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

HSHS Sacred Heart Hospital, Eau Claire

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

Virginia Piper Cancer Institute, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55417

Minneapolis VA Medical Center, Minneapolis

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55905

Mayo Clinic in Rochester, Rochester

56201

Rice Memorial Hospital, Willmar

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Montana Cancer Consortium NCORP, Billings

Saint Vincent Frontier Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59501

Northern Montana Hospital, Havre

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Deaconess Hospital, Bozeman

59802

Montana Cancer Specialists, Missoula

Saint Patrick Hospital - Community Hospital, Missoula

59901

Glacier Oncology PLLC, Kalispell

Kalispell Medical Oncology, Kalispell

Kalispell Regional Medical Center, Kalispell

60007

Ascension Alexian Brothers - Elk Grove Village, Elk Grove Village

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

60048

AMG Libertyville - Oncology, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60153

Loyola University Medical Center, Maywood

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60402

MacNeal Hospital and Cancer Center, Berwyn

60432

Midwest Center for Hematology Oncology, Joliet

60435

Duly Health and Care Joliet, Joliet

60504

Rush - Copley Medical Center, Aurora

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60563

DuPage Medical Group-Ogden, Naperville

60611

Hematology and Oncology Associates, Chicago

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

60640

Weiss Memorial Hospital, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

61104

Swedish American Hospital, Rockford

61108

OSF Saint Anthony Medical Center, Rockford

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Ottawa Regional Hospital and Healthcare Center, Ottawa

61354

Illinois CancerCare-Peru, Peru

Illinois Valley Hospital, Peru

61356

Illinois CancerCare-Princeton, Princeton

Perry Memorial Hospital, Princeton

61362

Illinois CancerCare-Spring Valley, Spring Valley

Saint Margaret's Hospital, Spring Valley

61401

Galesburg Cottage Hospital, Galesburg

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

Mcdonough District Hospital, Macomb

61462

Holy Family Medical Center, Monmouth

Illinois CancerCare-Monmouth, Monmouth

61520

Graham Hospital Association, Canton

Illinois CancerCare-Canton, Canton

61530

Eureka Hospital, Eureka

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin

Pekin Hospital, Pekin

61614

Proctor Hospital, Peoria

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

Saint Joseph Medical Center, Bloomington

61704

Illinois CancerCare-Bloomington, Bloomington

61747

Hopedale Medical Complex - Hospital, Hopedale

61761

Bromenn Regional Medical Center, Normal

Carle Cancer Institute Normal, Normal

Illinois CancerCare-Community Cancer Center, Normal

61801

Carle Cancer Center, Urbana

62002

Saint Anthony's Health, Alton

62321

Illinois CancerCare-Carthage, Carthage

Memorial Hospital, Carthage

62526

Decatur Memorial Hospital, Decatur

Heartland Cancer Research NCORP, Decatur

62644

Illinois CancerCare-Havana, Havana

Mason District Hospital, Havana

62781

Memorial Medical Center, Springfield

62864

Good Samaritan Regional Health Center, Mount Vernon

63104

SSM Health Saint Louis University Hospital, St Louis

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Center for Cancer Care and Research, St Louis

Comprehensive Cancer Care PC, St Louis

Mercy Hospital Saint Louis, St Louis

Saint Louis-Cape Girardeau CCOP, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64057

Centerpoint Medical Center LLC, Independence

64068

Liberty Radiation Oncology Center, Liberty

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64108

Truman Medical Centers, Kansas City

64111

Saint Luke's Hospital of Kansas City, Kansas City

64114

Radiation Oncology Practice Corporation South, Kansas City

Saint Joseph Health Center, Kansas City

64116

North Kansas City Hospital, Kansas City

64118

Heartland Hematology and Oncology Associates Incorporated, Kansas City

64132

Research Medical Center, Kansas City

64154

Radiation Oncology Practice Corporation - North, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64507

Saint Joseph Oncology Inc, Saint Joseph

65109

Capital Region Southwest Campus, Jefferson City

65212

University of Missouri - Ellis Fischel, Columbia

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66061

Olathe Cancer Center, Olathe

66112

Providence Medical Center, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66204

Advent Health - Shawnee Mission Medical Center, Shawnee Mission

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

66209

Menorah Medical Center, Overland Park

66210

Radiation Oncology Practice Corporation Southwest, Overland Park

66213

Saint Luke's South Hospital, Overland Park

66606

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka

University of Kansas Health System Saint Francis Campus, Topeka

66762

Ascension Via Christi - Pittsburg, Pittsburg

67214

Wesley Medical Center, Wichita

67401

Salina Regional Health Center, Salina

67502

Hutchinson Regional Medical Center, Hutchinson

67601

HaysMed University of Kansas Health System, Hays

68114

Nebraska Methodist Hospital, Omaha

68198

University of Nebraska Medical Center, Omaha

68803

CHI Health Saint Francis, Grand Island

75246

Baylor University Medical Center, Dallas

82609

Rocky Mountain Oncology, Casper

82801

Welch Cancer Center, Sheridan

85259

Mayo Clinic in Arizona, Scottsdale

87102

Lovelace Medical Center-Saint Joseph Square, Albuquerque

University of New Mexico Cancer Center, Albuquerque

88011

Memorial Medical Center - Las Cruces, Las Cruces

89102

University Medical Center of Southern Nevada, Las Vegas

89169

Nevada Cancer Research Foundation NCORP, Las Vegas

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

93420

PCR Oncology, Arroyo Grande

94040

Palo Alto Medical Foundation-Camino Division, Mountain View

94115

UCSF Medical Center-Mount Zion, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

06102

Hartford Hospital, Hartford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06856

Norwalk Hospital, Norwalk

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

46514-2098

Elkhart Clinic, Elkhart

04330

Harold Alfond Center for Cancer Care, Augusta

04401

Eastern Maine Medical Center, Bangor

20889-5600

Walter Reed National Military Medical Center, Bethesda

01805

Lahey Hospital and Medical Center, Burlington

03301

New Hampshire Oncology Hematology PA-Concord, Concord

03246

LRGHealthcare-Lakes Region General Hospital, Laconia

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

03102

Norris Cotton Cancer Center-Manchester, Manchester

03103

Solinsky Center for Cancer Care, Manchester

08103

Cooper Hospital University Medical Center, Camden

07018-1095

Veterans Adminstration New Jersey Health Care System, East Orange

08060

Virtua Memorial, Mount Holly

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

07503

Saint Joseph's Regional Medical Center, Paterson

08043

Virtua Voorhees, Voorhees Township

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

05602

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05405

University of Vermont and State Agricultural College, Burlington

05819

Norris Cotton Cancer Center-North, Saint Johnsbury

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

R3E 0V9

CancerCare Manitoba, Winnipeg

B3H 2Y9

QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

J4V 2H1

CSSS Champlain-Charles Le Moyne, Greenfield Park

H3A 1A1

McGill University Health Centre at Royal Victoria Hospital, Montreal

G1S 4L8

CHU de Quebec-Hopital du Saint-Sacrement (HSS), Québec

Sponsors
All Listed Sponsors
collaborator

Eastern Cooperative Oncology Group

NETWORK

collaborator

NCIC Clinical Trials Group

NETWORK

collaborator

SWOG Cancer Research Network

NETWORK

lead

National Cancer Institute (NCI)

NIH