Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology

PHASE3TerminatedINTERVENTIONAL
Enrollment

681

Participants

Timeline

Start Date

April 30, 2008

Primary Completion Date

March 31, 2011

Study Completion Date

September 30, 2012

Conditions
Carcinoma, Squamous CellCarcinoma, AdenosquamousCarcinoma, Large CellCarcinoma, Non-Small-Cell Lung
Interventions
DRUG

CP-751,871 (Figitumumab)

CP 751,871 is a potent and selective fully human monoclonal antibody against the insulin like growth factor 1 receptor (IGF-1R). Patients in Arm A will receive CP-751, 871 intravenously every 21 days for up to six cycles.

DRUG

Carboplatin

Carboplatin is a standard chemotherapeutic agent used in patients with lung cancer. Patients in Arm A will receive carboplatin intravenously every 21 days for up to six cycles.

DRUG

Paclitaxel

Paclitaxel is a standard chemotherapeutic agent used in patients with lung cancer. Patients in Arm A will receive paclitaxel intravenously every 21 days for up to six cycles.

DRUG

Carboplatin

Carboplatin is a standard chemotherapeutic agent used in patients with lung cancer. Patient in Arm B will receive carboplatin intravenously every 21 days for up to six cycles.

DRUG

Paclitaxel

Paclitaxel is a standard chemotherapeutic agent used in patients with lung cancer. Patient in Arm B will receive paclitaxel intravenously every 21 days for up to six cycles.

Trial Locations (280)

0

Pfizer Investigational Site, Kowloon

100

Pfizer Investigational Site, Taipei

112

Pfizer Investigational Site, Taipei

704

Pfizer Investigational Site, Tainan City

833

Pfizer Investigational Site, Niao Sung Hsiang

1233

Pfizer Investigational Site, Sofia

1525

Pfizer Investigational Site, Budapest

1527

Pfizer Investigational Site, Sofia

1708

Pfizer Investigational Site, Fribourg

1756

Pfizer Investigational Site, Sofia

2045

Pfizer Investigational Site, Törökbálint

2444

Pfizer Investigational Site, Port Macquarie

2640

Pfizer Investigational Site, Albury

3220

Pfizer Investigational Site, Geelong

3690

Pfizer Investigational Site, Wodonga

6772

Pfizer Investigational Site, Deszk

8000

Pfizer Investigational Site, Székesfehérvár

8091

Pfizer Investigational Site, Zurich

9000

Pfizer Investigational Site, Varna

9700

Pfizer Investigational Site, Szombathely

10043

Pfizer Investigational Site, Orbassano (TO)

10676

Pfizer Investigational Site, Athens

11030

Pfizer Investigational Site, Manhasset

11040

Pfizer Investigational Site, New Hyde Park

11042

Pfizer Investigational Site, Lake Success

11527

Pfizer Investigational Site, Athens

13126

Pfizer Investigational Site, Oswego

13210

Pfizer Investigational Site, Syracuse

13421

Pfizer Investigational Site, Oneida

14004

Pfizer Investigational Site, Córdoba

14033

Pfizer Investigational Site, Caen

14076

Pfizer Investigational Site, Caen

15025

Pfizer Investigational Site, Clairton

15090

Pfizer Investigational Site, Wexford

15132

Pfizer Investigational Site, McKeesport

15215

Pfizer Investigational Site, Pittsburgh

15232

Pfizer Investigational Site, Pittsburgh

15237

Pfizer Investigational Site, Pittsburgh

15601

Pfizer Investigational Site, Greensburg

15901

Pfizer Investigational Site, Johnstown

16132

Pfizer Investigational Site, Genova

18840

Pfizer Investigational Site, Sayre

19087

Pfizer Investigational Site, Radnor

19104

Pfizer Investigational Site, Philadelphia

19106

Pfizer Investigational Site, Philadelphia

20155

Pfizer Investigational Site, Gainesville

20176

Pfizer Investigational Site, Leesburg

21079

Pfizer Investigational Site, Dijon

21225

Pfizer Investigational Site, Baltimore

21237

Pfizer Investigational Site, Baltimore

22031

Pfizer Investigational Site, Fairfax

22191

Pfizer Investigational Site, Woodbridge

22205

Pfizer Investigational Site, Arlington

22601

Pfizer Investigational Site, Winchester

22927

Pfizer Investigational Site, Großhansdorf

24014

Pfizer Investigational Site, Roanoke

24073

Pfizer Investigational Site, Christiansburg

24153

Pfizer Investigational Site, Salem

24382

Pfizer Investigational Site, Wytheville

26121

Pfizer Investigational Site, Oldenburg

27215

Pfizer Investigational Site, Burlington

28033

Pfizer Investigational Site, Madrid

28500

Pfizer Investigational Site, Pori

29150

Pfizer Investigational Site, Sumter

29203

Pfizer Investigational Site, Columbia

30005

Pfizer Investigational Site, Alpharetta

30033

Pfizer Investigational Site, Decatur

30041

Pfizer Investigational Site, Cumming

30046

Pfizer Investigational Site, Lawrenceville

30060

Pfizer Investigational Site, Marietta

30078

Pfizer Investigational Site, Snellville

30094

Pfizer Investigational Site, Conyers

30096

Pfizer Investigational Site, Duluth

30236

Pfizer Investigational Site, Lake Spivey

30318

Pfizer Investigational Site, Atlanta

30341

Pfizer Investigational Site, Atlanta

30342

Pfizer Investigational Site, Atlanta

31008

Pfizer Investigational Site, Pamplona

31217

Pfizer Investigational Site, Macon

32024

Pfizer Investigational Site, Lake City

32055

Pfizer Investigational Site, Lake City

32207

Pfizer Investigational Site, Jacksonville

32504

Pfizer Investigational Site, Pensacola

32514

Pfizer Investigational Site, Pensacola

32550

Pfizer Investigational Site, Miramar Beach

32803

Pfizer Investigational Site, Orlando

32804

Pfizer Investigational Site, Orlando

34608

Pfizer Investigational Site, Spring Hill

34655

Pfizer Investigational Site, New Port Richey

34667

Pfizer Investigational Site, Hudson

34952

Pfizer Investigational Site, Port Saint Lucie

35033

Pfizer Investigational Site, Rennes

35128

Pfizer Investigational Site, Padua

35630

Pfizer Investigational Site, Florence

35661

Pfizer Investigational Site, Muscle Shoals

35805

Pfizer Investigational Site, Huntsville

37804

Pfizer Investigational Site, Maryville

37909

Pfizer Investigational Site, Knoxville

37916

Pfizer Investigational Site, Knoxville

37932

Pfizer Investigational Site, Knoxville

38119

Pfizer Investigational Site, Memphis

38120

Pfizer Investigational Site, Memphis

38133

Pfizer Investigational Site, Bartlett

38655

Pfizer Investigational Site, Oxford

38671

Pfizer Investigational Site, Southaven

38801

Pfizer Investigational Site, Tupelo

38834

Pfizer Investigational Site, Corinth

39008

Pfizer Investigational Site, Santander

39705

Pfizer Investigational Site, Columbus

40005

Pfizer Investigational Site, Sumy

40202

Pfizer Investigational Site, Louisville

40207

Pfizer Investigational Site, Louisville

44195

Pfizer Investigational Site, Cleveland

44202

Pfizer Investigational Site, Nantes

44622

Pfizer Investigational Site, Dover

44718

Pfizer Investigational Site, Canton

44805

Pfizer Investigational Site, Saint-Herblain

46010

Pfizer Investigational Site, Valencia

46107

Pfizer Investigational Site, Beech Grove

46123

Pfizer Investigational Site, Avon

46158

Pfizer Investigational Site, Mooresville

46237

Pfizer Investigational Site, Indianapolis

46260

Pfizer Investigational Site, Indianapolis

46321

Pfizer Investigational Site, Munster

46342

Pfizer Investigational Site, Hobart

46432

Pfizer Investigational Site, Hobart

48201

Pfizer Investigational Site, Detroit

48334

Pfizer Investigational Site, Farmington Hills

49085

Pfizer Investigational Site, Saint Joseph

49102

Pfizer Investigational Site, Dnipropetrovsk

52402

Pfizer Investigational Site, Cedar Rapids

55131

Pfizer Investigational Site, Mainz

55426

Pfizer Investigational Site, Saint Louis Park

56429

Pfizer Investigational Site, Thessaloniki

57001

Pfizer Investigational Site, Thessaloniki

60005

Pfizer Investigational Site, Arlington Heights

60007

Pfizer Investigational Site, Elk Grove Village

60190

Pfizer Investigational Site, Winfield

60504

Pfizer Investigational Site, Aurora

60560

Pfizer Investigational Site, Yorkville

60637

Pfizer Investigational Site, Chicago

61401

Pfizer Investigational Site, Galesburg

63003

Pfizer Investigational Site, Clermond-Ferrand Cedex 01

64064

Pfizer Investigational Site, Lee's Summit

64131

Pfizer Investigational Site, Kansas City

64154

Pfizer Investigational Site, Kansas City

66112

Pfizer Investigational Site, Kansas City

66204

Pfizer Investigational Site, Shawnee Mission

66210

Pfizer Investigational Site, Overland Park

68506

Pfizer Investigational Site, Lincoln

68510

Pfizer Investigational Site, Lincoln

68516

Pfizer Investigational Site, Lincoln

69317

Pfizer Investigational Site, Lyon

71913

Pfizer Investigational Site, Hot Springs

74104

Pfizer Investigational Site, Tulsa

74133

Pfizer Investigational Site, Tulsa

74136

Pfizer Investigational Site, Tulsa

75063

Pfizer Investigational Site, Irving

75601

Pfizer Investigational Site, Longview

75702

Pfizer Investigational Site, Tyler

76051

Pfizer Investigational Site, Grapevine

76111

Pfizer Investigational Site, Fort Worth

76137

Pfizer Investigational Site, Karlsruhe

76177

Pfizer Investigational Site, Fort Worth

77030

Pfizer Investigational Site, Houston

78229

Pfizer Investigational Site, San Antonio

78234

Pfizer Investigational Site, Fort Sam Houston

78665

Pfizer Investigational Site, Round Rock

78666

Pfizer Investigational Site, San Marcos

78681

Pfizer Investigational Site, Round Rock

78705

Pfizer Investigational Site, Austin

78731

Pfizer Investigational Site, Austin

78745

Pfizer Investigational Site, Austin

78758

Pfizer Investigational Site, Austin

79031

Pfizer Investigational Site, Lviv

80012

Pfizer Investigational Site, Aurora

80120

Pfizer Investigational Site, Littleton

80124

Pfizer Investigational Site, Lone Tree

80138

Pfizer Investigational Site, Parker

80218

Pfizer Investigational Site, Denver

80220

Pfizer Investigational Site, Denver

80228

Pfizer Investigational Site, Lakewood

80260

Pfizer Investigational Site, Thornton

80303

Pfizer Investigational Site, Boulder

80501

Pfizer Investigational Site, Longmont

80907

Pfizer Investigational Site, Colorado Springs

80909

Pfizer Investigational Site, Colorado Springs

83092

Pfizer Investigational Site, Donetsk

83814

Pfizer Investigational Site, Coeur d'Alene

84010

Pfizer Investigational Site, Bountiful

84041

Pfizer Investigational Site, Layton

84102

Pfizer Investigational Site, Salt Lake City

84106

Pfizer Investigational Site, Salt Lake City

84120

Pfizer Investigational Site, West Valley City

84157

Pfizer Investigational Site, Murray

84604

Pfizer Investigational Site, Provo

85012

Pfizer Investigational Site, Phoenix

85258

Pfizer Investigational Site, Scottsdale

89102

Pfizer Investigational Site, Las Vegas

89106

Pfizer Investigational Site, Las Vegas

94034

Pfizer Investigational Site, Nové Zámky

97448

Pfizer Investigational Site, Saint Pierre La Réunion Cedex

98104

Pfizer Investigational Site, Seattle

98122

Pfizer Investigational Site, Seattle

99202

Pfizer Investigational Site, Spokane Valley

99216

Pfizer Investigational Site, Spokane

99218

Pfizer Investigational Site, Spokane

111033

Pfizer Investigational Site, Moscow

115478

Pfizer Investigational Site, Moscow

194044

Pfizer Investigational Site, Saint Petersburg

197089

Pfizer Investigational Site, Saint Petersburg

198255

Pfizer Investigational Site, Saint Petersburg

354057

Pfizer Investigational Site, Sochi

440012

Pfizer Investigational Site, Nagpur

443066

Pfizer Investigational Site, Samara

06856

Pfizer Investigational Site, Norwalk

06360

Pfizer Investigational Site, Norwich

46158-1737

Pfizer Investigational Site, Mooresville

01842

Pfizer Investigational Site, Lawrence

02169

Pfizer Investigational Site, Quincy

02180

Pfizer Investigational Site, Stoneham

02189

Pfizer Investigational Site, Weymouth

01605

Pfizer Investigational Site, Worcester

03756-0001

Pfizer Investigational Site, Lebanon

03102

Pfizer Investigational Site, Manchester

13210-2306

Pfizer Investigational Site, Syracuse

75230-2510

Pfizer Investigational Site, Dallas

75075-7787

Pfizer Investigational Site, Plano

A-4010

Pfizer Investigational Site, Linz

A-1090

Pfizer Investigational Site, Vienna

20230-130

Pfizer Investigational Site, Rio de Janeiro

20231 -050

Pfizer Investigational Site, Rio de Janeiro

01224-010

Pfizer Investigational Site, Higienópolis

Pfizer Investigational Site, São Paulo

01219-000

Pfizer Investigational Site, São Paulo

01221-020

Pfizer Investigational Site, São Paulo

T6G 1Z2

Pfizer Investigational Site, Edmonton

G6V 3Z1

Pfizer Investigational Site, Lévis

262 04

Pfizer Investigational Site, Nová Ves pod Pleší

180 81

Pfizer Investigational Site, Prague

261 26

Pfizer Investigational Site, Pribram I

261 95

Pfizer Investigational Site, Pribram V

00290

Pfizer Investigational Site, Helsinki

04207

Pfizer Investigational Site, Leipzig

Unknown

Pfizer Investigational Site, Shatin, New Territories

Pfizer Investigational Site, Tuenmen

Pfizer Investigational Site, Kashiwa

Pfizer Investigational Site, Matsuyama

Pfizer Investigational Site, Gifu

Pfizer Investigational Site, Sapporo

Pfizer Investigational Site, Akashi

Pfizer Investigational Site, Yokohama

Pfizer Investigational Site, Osaka

Pfizer Investigational Site, Osakasayama-shi

Pfizer Investigational Site, Sakai-shi

Pfizer Investigational Site, Chuo-Ku

Pfizer Investigational Site, Tokyo

380 009

Pfizer Investigational Site, Navrangpura / Ahmedabad

560 078

Pfizer Investigational Site, Bangalore

400 012

Pfizer Investigational Site, Mumbai

110 030

Pfizer Investigational Site, New Delhi

00152

Pfizer Investigational Site, Roma

80-952

Pfizer Investigational Site, Gdansk

31-115

Pfizer Investigational Site, Krakow

08-110

Pfizer Investigational Site, Siedlce

01-138

Pfizer Investigational Site, Warsaw

02-097

Pfizer Investigational Site, Warsaw

02-781

Pfizer Investigational Site, Warsaw

53-439

Pfizer Investigational Site, Wroclaw

00716

Pfizer Investigational Site, Ponce

949 88

Pfizer Investigational Site, Nitra-Zobor

058 01

Pfizer Investigational Site, Poprad

410-769

Pfizer Investigational Site, Gyeonggi-do

110-744

Pfizer Investigational Site, Seoul

135-710

Pfizer Investigational Site, Seoul

138-736

Pfizer Investigational Site, Seoul

08907

Pfizer Investigational Site, L'Hospitalet de Llobregat

01330

Pfizer Investigational Site, Adana

06100

Pfizer Investigational Site, Ankara

03115

Pfizer Investigational Site, Kyiv

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT00596830 - Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology | Biotech Hunter | Biotech Hunter