Brain Oxygenation and Hemodynamics During Sleep in Obstructive Sleep Apnea Sufferers

PHASE3CompletedINTERVENTIONAL
Enrollment

309

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

June 30, 2010

Study Completion Date

June 30, 2010

Conditions
Obstructive Sleep Apnea Syndrome
Interventions
DEVICE

OxiplexTS

OxiplexTS is a Frequency Domain Near-Infrared Tissue oximeter which provides absolute values of tissue oxygenation in real time. It also provides physiological quantities of oxy, deoxy and total hemoglobin concentration, which form the basis for the functional measurement of brain hemodynamics. Both the control and OSA groups will undergo standard overnight sleep study (PSG). In addition to the standard PSG, with or without Continuous Positive Airway Pressure (CPAP), we will add the OxiplexTS, allowing us to assess brain oxygenation and hemodynamics during sleep. The hemodynamic patterns of the healthy controls will be compared to the OSA sufferers. Participants with OSA who undergo PSG/CPAP will be also tested with the OxiplexTS. Their PSGs and PSG/CPAP data will be compared.

Trial Locations (4)

60612

Center of Sleep and Ventilatory Disorders, University of Illinois Medical Center at Chicago, 2200 W Harrison, Chicago

61801

Carle Regional Sleep Disorders Center, Carle Foundation Hospital, 611 West Park Street, Urbana

92868

University of California-Irvine Sleep Disorders Center, 101 The City Drive South, Bldg. 22C, 2nd Floor, Rt. 23, Orange

94305

Stanford Sleep Disorders Clinic, Psychiatry Building, 401 Quarry Road, Stanford

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

collaborator

Carle Foundation Hospital

OTHER

collaborator

University of Illinois at Chicago

OTHER

collaborator

University of California, Irvine

OTHER

lead

ISS, Inc.

INDUSTRY

NCT00591591 - Brain Oxygenation and Hemodynamics During Sleep in Obstructive Sleep Apnea Sufferers | Biotech Hunter | Biotech Hunter