NCT00588133View on ClinicalTrials.gov

A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery

PHASE3CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

January 31, 2004

Primary Completion Date

December 31, 2007

Study Completion Date

August 31, 2008

Conditions

Cardiac Surgery

Interventions

DRUG

tranexamic acid

"Loading dose: 6.6 mg/kg Prime dose: 50 mg for 2.5 Liter circuit (assuming 1 L/kg Vd in prime fluids), 40 mg for 2 Liter circuit Rate of infusion: 6 mg/kg/hr~Renal Insufficiency (normal loading dose and prime dose):~Serum Creatinine = 1.6-3.3: reduce infusion to 4.5 mg/kg/hr Serum Creatinine = 3.3-6.6: reduce infusion to 3.0 mg/kg/hr Serum Creatinine = \>6.6: reduce infusion to 1.5 mg/kg/hr"

DRUG

tranexamic acid

10 mg/kg tranexamic acid given over 20 minutes followed by an infusion of 1 mg/kg/hr