Safety Trial of NK Cell DLI 3-5/6 Family Member Following Nonmyeloablative ASCT

PHASE1CompletedINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

April 30, 2005

Primary Completion Date

April 30, 2013

Study Completion Date

November 30, 2013

Conditions
Lymphoma
Interventions
DEVICE

NK-CD56

NK Cell infusion using CD56 monoclonal antibody following nonmyeloablative SCT from mismatched donors: The cells from leukapheresis will be NK selected using a CD56 antibody and a cell column system provided by Miltenyi Biotec. The target cell dose for each NK cell infusion will be up to 1 X 10(7) CD56+ cells/kg patient weight with less than 0.5 X 10(6) CD3+ cells/kg patient weight. The first NK cell infusion will be administered 6 weeks post transplant in patients who have ≤ grade II aGVHD at the time of infusion. Patients will be evaluated for toxicity and response until 20 weeks after the last NK Infusion.

Trial Locations (1)

27710

Duke University Health Systems, Durham

All Listed Sponsors
lead

David Rizzieri, MD

OTHER

NCT00586703 - Safety Trial of NK Cell DLI 3-5/6 Family Member Following Nonmyeloablative ASCT | Biotech Hunter | Biotech Hunter