Study of Fludarabine Based Conditioning for Allogeneic Stem Cell Transplantation for Myelofibrosis

PHASE2CompletedINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

August 31, 2011

Study Completion Date

June 15, 2015

Conditions
Myelofibrosis
Interventions
DRUG

Fludarabine, Melphalan +/- ATG

"Conditioning regimen for Allogenic Stem Cell Transplant:~Related Donor Fludarabine days -6 to -2 (30mg/m2 IVPB over 30 minutes daily) Melphalan days -3 to -2 (70mg/m2 IVPB over 30 minutes daily)~Unrelated Donor Fludarabine days -6 to -2 (30mg/m2 IVPB over 30 minutes daily) Melphalan days -3 to -2 (70mg/m2 IVPB over 30 minutes daily) ATG (Thymoglobulin®) days -3 to -1 (0.5 mg/kg IV on day -3 \[given over 6 hours\], and 2 mg/kg on days -2 and -1 \[given over 4 hours\])"

Trial Locations (12)

10029

Icahn School of Medicine at Mount Sinai, New York

10065

Weill Cornell Medical College, New York

14263

Roswell Park Cancer Institute, Buffalo

21205

Johns Hopkins, Baltimore

24128

Ospedali Riuniti di Bergamo, Bergamo

43210

Ohio State Univesity, Columbus

60302

University of Florence, Florence

Regionala etikprovningsnamnden Goteborg, Gothenburg

60612

University of Illinois at Chicago, Chicago

84132

University of Utah, Salt Lake City

M5G2M9

Princess Margaret Hospital, Toronto

Unknown

University of San Martino, San Martino

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

Myeloproliferative Disorders-Research Consortium

NETWORK

collaborator

National Cancer Institute (NCI)

NIH

lead

John Mascarenhas

OTHER

NCT00572897 - Study of Fludarabine Based Conditioning for Allogeneic Stem Cell Transplantation for Myelofibrosis | Biotech Hunter | Biotech Hunter