A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis

PHASE3CompletedINTERVENTIONAL
Enrollment

1,465

Participants

Timeline

Start Date

November 30, 2007

Primary Completion Date

June 30, 2009

Study Completion Date

June 30, 2009

Conditions
Plaque Psoriasis
Interventions
DRUG

Placebo

Two injections at weeks 0 and 4. One injection at week 8. At week 12, arm is rerandomized to placebo every 4 weeks.

BIOLOGICAL

ABT-874

200mg at week 0 and week 4. 100mg at week 8. On week 12, arm is rerandomized to 100mg every 4 weeks.

BIOLOGICAL

ABT-874

100mg every 12 weeks.

Trial Locations (116)

10016

Site Reference ID/Investigator# 7876, New York

10025

Site Reference ID/Investigator# 6599, New York

10032

Site Reference ID/Investigator# 7637, New York

11790

Site Reference ID/Investigator# 7018, Stoney Brook

14221

Site Reference ID/Investigator# 7878, Buffalo

14623

Site Reference ID/Investigator# 7504, Rochester

17033

Site Reference ID/Investigator# 7879, Hershey

19103

Site Reference ID/Investigator# 6712, Philadelphia

23507

Site Reference ID/Investigator# 6807, Norfolk

27157

Site Reference ID/Investigator# 8251, Winston-Salem

28401

Site Reference ID/Investigator# 7293, Wilmington

28601

Site Reference ID/Investigator# 6926, Hickory

29651

Site Reference ID/Investigator# 6589, Greer

30022

Site Reference ID/Investigator# 6582, Alpharetta

30078

Site Reference ID/Investigator# 6717, Snellville

30263

Site Reference ID/Investigator# 6714, Newnan

30327

Site Reference ID/Investigator# 7450, Atlanta

32204

Site Reference ID/Investigator# 6707, Jacksonville

33136

Site Reference ID/Investigator# 7301, Miami

33143

Site Reference ID/Investigator# 7016, South Miami

33144

Site Reference ID/Investigator# 7012, Miami

33173

Site Reference ID/Investigator# 6831, Miami

33407

Site Reference ID/Investigator# 6590, West Palm Beach

35205

Site Reference ID/Investigator# 6579, Birmingham

35233

Site Reference ID/Investigator# 6697, Birmingham

35801

Site Reference ID/Investigator# 7015, Huntsville

37072

Site Reference ID/Investigator# 6586, Goodlettsville

37215

Site Reference ID/Investigator# 6915, Nashville

37934

Site Reference ID/Investigator# 7668, Knoxville

40202

Site Reference ID/Investigator# 6873, Louisville

42303

Site Reference ID/Investigator# 7523, Owensboro

43212

Site Reference ID/Investigator# 7165, Columbus

44106

Site Reference ID/Investigator# 8082, Cleveland

45219

Site Reference ID/Investigator# 6598, Cincinnati

45408

Site Reference ID/Investigator# 7659, Dayton

46256

Site Reference ID/Investigator# 6706, Indianapolis

46260

Site Reference ID/Investigator# 7646, Indianapolis

48059

Site Reference ID/Investigator# 6826, Fort Gratiot

48202

Site Reference ID/Investigator# 7644, Detroit

48439

Site Reference ID/Investigator# 7989, Grand Blanc

53209

Site Reference ID/Investigator# 7080, Milwaukee

55432

Site Reference ID/Investigator# 6581, Fridley

60005

Site Reference ID/Investigator# 7017, Arlington Heights

60077

Site Reference ID/Investigator# 6704, Skokie

60118

Site Reference ID/Investigator# 7292, West Dundee

60153

Site Reference ID/Investigator# 7877, Maywood

63110

Site Reference ID/Investigator# 7890, St Louis

63117

Site Reference ID/Investigator# 6709, St Louis

66202

Site Reference ID/Investigator# 7014, Overland Park

68144

Site Reference ID/Investigator# 7451, Omaha

72205

Site Reference ID/Investigator# 6696, Little Rock

75230

Site Reference ID/Investigator# 6822, Dallas

75703

Site Reference ID/Investigator# 6912, Tyler

76011

Site Reference ID/Investigator# 6825, Arlington

77030

Site Reference ID/Investigator# 6705, Houston

77598

Site Reference ID/Investigator# 7306, Webster

78229

Site Reference ID/Investigator# 6708, San Antonio

Site Reference ID/Investigator# 7081, San Antonio

78759

Site Reference ID/Investigator# 6762, Austin

80209

Site Reference ID/Investigator# 7302, Denver

80501

Site Reference ID/Investigator# 6921, Longmont

84132

Site Reference ID/Investigator# 8101, Salt Lake City

85251

Site Reference ID/Investigator# 6728, Scottsdale

85710

Site Reference ID/Investigator# 6584, Tucson

87106

Site Reference ID/Investigator# 7030, Albuquerque

90045

Site Reference ID/Investigator# 6872, Los Angeles

90404

Site Reference ID/Investigator# 6711, Santa Monica

90503

Site Reference ID/Investigator# 8139, Torrance

92056

Site Reference ID/Investigator# 7669, Oceanside

92103

Site Reference ID/Investigator# 6821, San Diego

92117

Site Reference ID/Investigator# 6832, San Diego

92123

Site Reference ID/Investigator# 7305, San Diego

92697

Site Reference ID/Investigator# 7885, Irvine

93309

Site Reference ID/Investigator# 6591, Bakersfield

93720

Site Reference ID/Investigator# 6710, Fresno

94118

Site Reference ID/Investigator# 7990, San Francisco

94589

Site Reference ID/Investigator# 7167, Vallejo

97035

Site Reference ID/Investigator# 6727, Lake Oswego

97210

Site Reference ID/Investigator# 6894, Portland

97223

Site Reference ID/Investigator# 6578, Portland

97239

Site Reference ID/Investigator# 7295, Portland

98101

Site Reference ID/Investigator# 6801, Seattle

99204

Site Reference ID/Investigator# 7519, Spokane

06511

Site Reference ID/Investigator# 6917, New Haven

01810

Site Reference ID/Investigator# 6597, Andover

02111

Site Reference ID/Investigator# 6703, Boston

08009

Site Reference ID/Investigator# 7299, Berlin

08520

Site Reference ID/Investigator# 6924, East Windsor

08903

Site Reference ID/Investigator# 6577, New Brunswick

10029-6501

Site Reference ID/Investigator# 6895, New York

02919

Site Reference ID/Investigator# 6580, Johnston

02903

Site Reference ID/Investigator# 6576, Providence

75246-1613

Site Reference ID/Investigator# 7671, Dallas

L4M 6L2

Site Reference ID/Investigator# 7314, Barrie

T3A 2N1

Site Reference ID/Investigator# 7452, Calgary

T5K 1X3

Site Reference ID/Investigator# 6702, Edmonton

B3H 0A2

Site Reference ID/Investigator# 6716, Halifax

L8N 1V6

Site Reference ID/Investigator# 7309, Hamilton

H7S 2C6

Site Reference ID/Investigator# 6588, Laval

N5X 2P1

Site Reference ID/Investigator# 6715, London

N6A 3H7

Site Reference ID/Investigator# 7315, London

L3P 1A8

Site Reference ID/Investigator# 7636, Markham

H2K 4L5

Site Reference ID/Investigator# 6699, Montreal

H3H 1V4

Site Reference ID/Investigator# 7316, Montreal

P1B 3Z7

Site Reference ID/Investigator# 7088, North Bay

K2G 6E2

Site Reference ID/Investigator# 7310, Ottawa

G1V 4X7

Site Reference ID/Investigator# 7311, Québec

A1A 5E8

Site Reference ID/Investigator# 7313, St. John's

V3R 6A7

Site Reference ID/Investigator# 7317, Surrey

V5Z 3Y1

Site Reference ID/Investigator# 7308, Vancouver

V5Z 4E8

Site Reference ID/Investigator# 6713, Vancouver

N2J 1C4

Site Reference ID/Investigator# 7067, Waterloo

H3Z 2S6

Site Reference ID/Investigator# 7312, Westmount

N8W 1E6

Site Reference ID/Investigator# 7087, Windsor

N8W 5L7

Site Reference ID/Investigator# 6805, Windsor

R3C 1R4

Site Reference ID/Investigator# 7638, Winnipeg

All Listed Sponsors
lead

AbbVie (prior sponsor, Abbott)

INDUSTRY

NCT00570986 - A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis | Biotech Hunter | Biotech Hunter