27
Participants
Start Date
May 11, 2005
Primary Completion Date
August 2, 2012
Study Completion Date
August 2, 2012
high performance liquid chromatography
urine analysis
laboratory biomarker analysis
The biomarkers of interest will be the metabolites 4-OHE1(E2), estrogen-GSH conjugates and depurinating estrogen-DNA adducts.
mass spectrometry
The urine samples will be analyzed for 40 estrogen metabolites, conjugates and depurinating DNA adducts by UPLC with tandem mass spectrometric detection.
medical chart review
Collection of information about age, race, general health, any endocrine disorders, history of cancer, estrogen and progesterone receptor status, menopausal status and breast disease.
Mayo Clinic Cancer Center, Rochester
Eppley Cancer Center at University of Nebraska Medical Center, Omaha
National Cancer Institute (NCI)
NIH
University of Nebraska
OTHER