665
Participants
Start Date
November 5, 2007
Primary Completion Date
February 27, 2015
Study Completion Date
March 31, 2022
Autologous Hematopoietic Stem Cell Transplantation
Undergo autologous peripheral blood stem cell transplant
Carboplatin
Given IV
Cisplatin
Given IV
Cyclophosphamide
Given IV
Doxorubicin Hydrochloride
Given IV
Etoposide
Given IV
External Beam Radiation Therapy
Undergo EBRT
Filgrastim
Given IV or SC
Isotretinoin
Given orally
Laboratory Biomarker Analysis
Correlative studies
Melphalan
Given IV
Peripheral Blood Stem Cell Transplantation
Undergo autologous peripheral blood stem cell transplant
Pharmacological Study
Correlative studies
Thiotepa
Given IV
Topotecan Hydrochloride
Given IV
Vincristine Sulfate Liposome
Given IV
Starship Children's Hospital, Grafton
The Children's Hospital at Westmead, Westmead
Westmead Hospital, Westmead
Swiss Pediatric Oncology Group - Bern, Bern
Royal Brisbane and Women's Hospital, Herston
Royal Children's Hospital-Brisbane, Herston
Princess Margaret Hospital for Children, Perth
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Mount Sinai Hospital, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
New York Medical College, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Brooklyn Hospital Center, Brooklyn
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Geisinger Medical Center, Danville
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
Children's National Medical Center, Washington D.C.
University of Maryland/Greenebaum Cancer Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Fairfax Hospital, Falls Church
University of Virginia Cancer Center, Charlottesville
Virginia Commonwealth University/Massey Cancer Center, Richmond
Carilion Clinic Children's Hospital, Roanoke
West Virginia University Charleston Division, Charleston
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Mission Hospital Inc-Memorial Campus, Asheville
Prisma Health Richland Hospital, Columbia
Medical University of South Carolina, Charleston
BI-LO Charities Children's Cancer Center, Greenville
Greenville Cancer Treatment Center, Greenville
Children's Healthcare of Atlanta - Egleston, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Augusta University Medical Center, Augusta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
Sacred Heart Hospital, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
Florida Hospital Orlando, Orlando
Nemours Children's Clinic - Orlando, Orlando
UF Cancer Center at Orlando Health, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Broward Health Medical Center, Fort Lauderdale
Saint Mary's Hospital, West Palm Beach
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Lee Memorial Health System, Fort Myers
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
University of Alabama at Birmingham Cancer Center, Birmingham
USA Health Strada Patient Care Center, Mobile
Vanderbilt University/Ingram Cancer Center, Nashville
T C Thompson Children's Hospital, Chattanooga
East Tennessee Childrens Hospital, Knoxville
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
The Toledo Hospital/Toledo Children's Hospital, Toledo
Mercy Children's Hospital, Toledo
University of Toledo, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
Riley Hospital for Children, Indianapolis
Saint Vincent Hospital and Health Care Center, Indianapolis
C S Mott Children's Hospital, Ann Arbor
Wayne State University/Karmanos Cancer Institute, Detroit
Ascension Saint John Hospital, Detroit
Hurley Medical Center, Flint
Bronson Methodist Hospital, Kalamazoo
Kalamazoo Center for Medical Studies, Kalamazoo
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids
Spectrum Health at Butterworth Campus, Grand Rapids
Blank Children's Hospital, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Hospital and Clinics, Madison
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic, Rochester
Sanford Broadway Medical Center, Fargo
Loyola University Medical Center, Maywood
Lurie Children's Hospital-Chicago, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Southern Illinois University School of Medicine, Springfield
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
University of Missouri - Ellis Fischel, Columbia
University of Kansas Cancer Center, Kansas City
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Tulane University Health Sciences Center, New Orleans
Children's Hospital New Orleans, New Orleans
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Methodist Children's Hospital of South Texas, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Covenant Children's Hospital, Lubbock
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
The University of Arizona Medical Center-University Campus, Tucson
University of New Mexico Cancer Center, Albuquerque
Nevada Cancer Research Foundation CCOP, Las Vegas
Children's Hospital Los Angeles, Los Angeles
Cedars Sinai Medical Center, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Harbor-University of California at Los Angeles Medical Center, Torrance
Miller Children's and Women's Hospital Long Beach, Long Beach
City of Hope Comprehensive Cancer Center, Duarte
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
Valley Children's Hospital, Madera
UCSF Medical Center-Mount Zion, San Francisco
UCSF Medical Center-Parnassus, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
Kaiser Permanente-Oakland, Oakland
University of California Davis Comprehensive Cancer Center, Sacramento
Legacy Emanuel Children's Hospital, Portland
Legacy Emanuel Hospital and Health Center, Portland
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Madigan Army Medical Center, Tacoma
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Arkansas Children's Hospital, Little Rock
Children's Hospital and Research Center at Oakland, Oakland
University of Connecticut, Farmington
Connecticut Children's Medical Center, Hartford
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Walter Reed National Military Medical Center, Bethesda
Floating Hospital for Children at Tufts Medical Center, Boston
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
University of Massachusetts Medical School, Worcester
Michigan State University Clinical Center, East Lansing
Dartmouth Hitchcock Medical Center, Lebanon
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Saint Peter's University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Saint Joseph's Regional Medical Center, Paterson
Overlook Hospital, Summit
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Vermont and State Agricultural College, Burlington
Naval Medical Center - Portsmouth, Portsmouth
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Kingston Health Sciences Centre, Kingston
Children's Hospital, London
Victoria Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Centre Hospitalier Universitaire de Quebec, Québec
San Jorge Children's Hospital, San Juan
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK