Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Original Study

NACompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

October 31, 2007

Primary Completion Date

September 30, 2012

Study Completion Date

September 30, 2012

Conditions
Schizophrenia
Interventions
DEVICE

Magstim Rapid 2 system triggering Magstim Super Rapid system

Week 1 treatment includes rTMS for 5 sessions to either to left or right Wernicke's area (BA22) synchronous with rTMS to opposite hemisphere middle temporal cortex (BA21). Week 2 treatment includes rTMS given for 5 sessions with positions reversed (e.g., if Wernicke's stimulation was on the left during Week 1, position of rTMS will switch to the right side during Week 2 and vice-versa). As in Week 1, active rTMS will also be given synchronously to the opposite hemisphere middle temporal cortex. Weeks 3 and 4 include 10 stimulation sessions to the configuration of sites producing greater improvement in comparing results of Week 1 and Week 2. rTMS for each stimulation session will be given at 1-Hertz (once per second) for 16 minutes without interruption.

DEVICE

Magstim Rapid-2 system triggering Magstim Super Rapid system

Week 1 includes repetitive rTMS for 5 sessions to either to left or right Wernicke's area (BA22) synchronous with sham rTMS to opposite hemisphere middle temporal cortex (BA21). Week 2 includes rTMS given for 5 sessions with positions reversed (e.g., if Wernicke's stimulation was on the left during Week 1, position of rTMS will switch to the right side during Week 2 and vice-versa). As in Week 1, sham rTMS will also be given synchronously to the opposite hemisphere middle temporal cortex. Weeks 3 and 4 include 10 stimulation sessions to the configuration of sites producing greater improvement in comparing results of Week 1 and Week 2. rTMS for each stimulation session will be given at 1-Hertz (once per second) for 16 minutes without interruption.

Trial Locations (1)

06519

Department of Psychiatry, Yale School of Medicine, New Haven

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Yale University

OTHER

NCT00567281 - Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Original Study | Biotech Hunter | Biotech Hunter