808
Participants
Start Date
February 12, 2008
Primary Completion Date
May 13, 2011
Study Completion Date
November 23, 2018
Pertuzumab
Pertuzumab was administered as an intravenous (IV) loading dose of 840 milligrams (mg) q3w on Day 1 of Cycle 1 (1 Cycle length = 21 days), and 420 mg q3w on Day 1 of subsequent cycles until investigator-assessed radiographic or clinical progressive disease, unmanageable toxicity, or study termination.
Placebo
Placebo (matching pertuzumab) was administered intravenously.
Trastuzumab
Trastuzumab was administered as an IV loading dose of 8 milligrams per kilogram (mg/kg) q3w on Day 2 of Cycle 1 (1 Cycle length = 21 days), and 6 mg/kg q3w on Day 1 of subsequent cycles until investigator-assessed radiographic or clinical progressive disease, unmanageable toxicity, or study termination.
Docetaxel
Docetaxel was administered as an IV dose of 75 milligrams per square meter of body surface area (mg/m\^2) q3w on Day 2 of Cycle 1 (1 Cycle length = 21 days), and 75 mg/m\^2 (up to 100 mg/m\^2 as per treating physician discretion) q3w on Day 1 of subsequent cycles until investigator-assessed radiographic or clinical progressive disease, unmanageable toxicity, or study termination. On or prior to Cycle 6, docetaxel was only to be discontinued for progressive disease or unmanageable toxicity. After Cycle 6, continuation of docetaxel treatment was at the discretion of the participant and treating physician.
Institute of Radiotherapy Oncology, Skopje
Private Health Organization Acibadem Sistina Hospital, Skopje
Veterans Memorial Medical Center; Oncology, Quezon City
St Luke'S Medical Centre; Oncology, Quezon City
Sanatorio Güemes; Oncología, Buenos Aires
Instituto Medico Especializado (IME); Oncologia, Caba
Hospital Carlos Andrade Marin; Servicio de Oncología, Quito
Center Instituto Médico Privado I.M.P.; Oncology, Chaco-resistencia
Daugavpils Regional Hospital, Daugavpils
Cebu Cancer Institute; Perpetual Succour Hospital, Cebu City
Clinical Hospital; Oncology Department, Bitola
Clinical Hospital Sisters of Mercy, Zagreb
University Hospital Centre Zagreb; Clinic For Oncology, Zagreb
Beth Israel Comprehensive Cancer Center Pharmacy, New York
The Women'sOncology & Wellness Practice, New York
Fondazione Del Piemonte Per L'oncologia IRCC Di Candiolo, Candiolo
Hospital Cima San Jose; Oncology, San José
Chulalongkorn Hospital; Medical Oncology, Bangkok
National Cancer Inst., Bangkok
Rajavithi Hospital; Division of Medical Oncology, Bangkok
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc, Bangkok
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok
ProHEALTH Care Associates LLP, Lake Success
Onkologischer Schwerpunkt am Oskar-Helene-Heim; Dres. Herrenberger, Keitel-Wittig u. Kirsch, Berlin
Brockport-Interlakes Foundation, Brockport
Canandaigua-Interlakes Found, Canandaigua
Geneva-Interlakes Foundation, Geneva
Upstate Ny Cancer Research & Education Foundation, Rochester
Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología, A Coruña
Uni of Pittsburgh; Magee-Women'S Hospital, Pittsburgh
Armstrong County Memorial Hospital, Kittanning
Cons in Med Onc and Hem, Darby
Consultants in Medical Oncology/Hematology, Drexel Hill
Conslts in Med Onc (Newtown); Bryn Mawr Health Canc Ctr, Newtown Square
Consultants Med Onc & Hem, Ridley Park
Georgetown University Medical Center Lombardi Cancer Center, Washington D.C.
MedStar Washington Hosp Center, Washington D.C.
Sibley Memorial Hospital, Washington D.C.
Universitätsklinikum Hamburg-Eppendorf; Frauenklinik, Hamburg
Turku Uni Central Hospital; Oncology Clinics, Turku
Private Practice- Carolyn Hendricks, MD, Bethesda
Centre Georges Francois Leclerc; Oncologie 3, Dijon
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia, Jaén
Wellmonth Physician Services, Bristol
Az. Osp. Spedali Civili; Divisione Di Oncologia - Iii Medicina, Brescia
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia, Lleida
Duke University Medical Center, Durham
Centro Oncologico MD Anderson Internacional; Servicio de Oncologia, Madrid
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid
Carolina BioOncology Institute, PLCC, Huntersville
Carolina Oncology Specialists, PA - Hickory, Hickory
NW Carolina Onc & Hem, Lenoir
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga
Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Marietta
Northeast Georgia Medical Center; Oncology Research Dept-5C, Gainesville
Central Georgia Hematology Oncology Associates, Macon
Private Practice Robert R. Carroll, Md, Pa, Gainesville
Private Practice, Orlando
Clinique Tivoli; Sce Radiotherapie, Bordeaux
Memorial Cancer Institute, Hollywood
Memorial Regional Hospital, Hollywood
Breast Cancer Centre at Memorial Hospital West, Pembroke Pines
Jackson Memorial Hospital, Miami
University of Miami School of Medicine, Miami
Cleveland Clinic Florida, Weston
Boca Raton Comprehensive Cancer Center, Boca Raton
UM Sylvester Deerfield Beach; Sylvester Cancer Ctr, Deerfield Beach
Tampere University Hospital; Dept of Oncology, Tampere
Onkologische Schwerpunktpraxis Bielefeld; Haemotologie & Internistische onkologie, Bielefeld
Bay Area Oncology, Tampa
Florida Cancer Specialists - Broadway, Fort Myers
Florida Cancer Specialists; SCRI, Fort Myers
Florida Cancer Specialists-Broadway, Fort Myers, Fort Myers
Florida Cancer Specialists -Cape Coral (Cape Coral Pkwy), Cape Coral
Florida Cancer Specialists - Port Charlotte, Port Charlotte
Florida Cancer Specialists - Venice (S. Tamiami Tr), Venice
Florida Cancer Specialists - Cape Coral (Del Prado Blvd), Cape Coral
Florida Cancer Specialists - Goodlette, Naples, Naples
Florida Cancer Specialists - Pine Ridge, Naples, Naples
Florida Cancer Specialists - Englewood, Englewood
Florida Cancer Specialists; Sarasota, Sarasota
Florida Cancer Specialists - Sunset Lake, Venice, Venice
Sarah Cannon Cancer Center - Tennessee Oncology, Pllc, Nashville
Erlanger Health System; Oncology Research, Chattanooga
SCRI Tennessee Oncology Chattanooga, Chattanooga
McLeod Cancer and Blood Center, Johnson City
University of Tennessee Cancer Institute;Hem-Onc Consultants, Knoxville
Hospital Universitario de Canarias;servicio de Oncologia, San Cristóbal de La Laguna
The Jones Clinic, PC, New Albany
Jewish Cancer Care, Louisville
Hematology Oncology Consultants (NWK), Granville
Hema Onc Conslts-Grant Ave, Columbus
The Mark H. Zangmeister Ctr; Mid Ohio Onc/Hem Inc., Columbus
Hematology Onc Consultants, Columbus
Medical College of Ohio; Cancer Institute, Toledo
Gabrail Cancer Center, Dover
Gabrail Cancer Center, Canton
Ico Rene Gauducheau; Oncologie, Saint-Herblain
Universitätsklinikum Essen; Zentrum Für Frauenheilkunde, Essen
Oncology Hematology Care Inc, Cincinnati
Hematology-Oncology of Indiana, Pc, Indianapolis
Community Hospital; Pharmacy, Munster
Northwest Oncology, Munster
Monroe Medical Associates - Hobart, Hobart
Monroe Medical Associates, Munster
St. Mary Medical Center, Hobart
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola
Family Medicine Vincennes, Vincennes
Ospedale Provinciale Santa Maria delle Croci, Ravenna
Oncology Care Associates PLLC, Saint Joseph
Cancer & Hematology Centers of Western Michigan, Grand Rapids
Cancer & Hematology Center of West Michigan, Grand Rapids
Azienda Sanitaria S. Maria Annunziata; S. C. Oncologia Medica, Antella (FI)
Centro Oncologico Estatal ISSEMYM, Toluca
St. Elisabeth Krankenhaus Köln GmbH; Gynäkologie und Geburtshilfe, Cologne
Haematologisch-Onkologische Praxis; Dr. med. Christoph Maintz und Matthias Groschek, Würselen
Uni of Iowa Hospital&Clinic; Holden Comprehens. Cancer Ctr, Iowa City
Klinikum Mutterhaus der Borromaeerinnen gGmbH; Haematologie/Onkologie, Trier
Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde, Mainz
US Oncology Research at Minnesota Oncology, Minneapolis
Southdale Cancer Clinic U of M Medical Center, Fairview- Edina, Edina
Ospedale Misericordia E Dolce; Oncologia Medica, Prato
St. Vincent Frontier Cancer Center, Billings
Midwestern Regional Medical Center; Office of Research, Zion
Elmhurst Hospital, Elmhurst
Hematology Oncology Consultants Ltd, Naperville
Ospedale Di Macerata; Oncologia, Macerata
Quincy Medical Group, Quincy
Centre Oncologie Du Pays Basque, Bayonne
Policlinico Ospedaliero Ss Annunziata; U.O. Di Clinica Oncologica, Chieti
University of Kansas; Medical Center & Medical pavilion, Westwood
Hematology-Oncology Consultants, Pc, Omaha
Southeast Nebraska Cancer Center;; Southeast Nebraska Hematology and Oncology, Lincoln
Norfolk Oncology Consultants, Norfolk
Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg, Heidelberg
Robert-Bosch-Krankenhaus; Hämatologie, Onkologie und Palliativmedizin, Stuttgart
Cancer Center of Acadiana at Lafayette General, Lafayette
Centre Jean Bernard, Le Mans
Universitätsklinik Tübingen; Frauenklinik, Tübingen
Ospedale Antonio Perrino; Oncologia Medica, Brindisi
NEA Baptist Clinic, Jonesboro
Mercy Physicians of Oklahoma, Oklahoma City
CA Care Associates-OK Oncology and Hematology, Tulsa
Cancer Care Assoc-S. Ingo, Tulsa
OK Oncology & Hematology PC, Tulsa
Park Plaza, Houston
Southwest, Houston
St. Joseph's, Houston
Memorial City-Main Office, Houston
Oncology Consultants, Houston
St. Luke's, Houston
Willowbrook, Houston
Katy-Christus St. Catherine, Katy
Oncology Consultants - Sugar Land, Sugar Land
South Texas Oncology Hematology, San Antonio
Krankenhaus Rheinfelden; Frauenklinik, Rheinfelden
Groupe Hospitalier Sud; Oncologie Radiotherapie, Salouël
Northern Utah Associates, Ogden
HonorHealth Research Institute - Bisgrove, Scottsdale
Centre Hospitalier Departemental Les Oudairies, La Roche-sur-Yon
San Juan Oncology Associates, Farmington
Southern Nevada Cancer Research Foundation, Las Vegas
UCLA, Los Angeles
LAC USC Medical Center, Los Angeles
Cedars- Sinai Medical Center, Los Angeles
Ronald Reagan UCLA Medical Center Clin Lab, Los Angeles
TORI Central Administration, Los Angeles
UCLA Hematology / Oncology Clinic, Los Angeles
UCLA Med Ctr; Pharma Svcs, Los Angeles
Songklanagarind Hospital; Department of Oncology, Songkhla
Tower Cancer Research Foundation, Beverly Hills
UCLA Hematology/Oncology, Santa Monica
Innovative clinical research institute/American institute of research, Whittier
UCLA Healthcare/Pasadena Oncology, Pasadena
UCLA / Santa Clarita Valley Cancer Center, Valencia
Kaiser Permanente - Baldwin Park, Baldwin Park
Wilshire Oncology Medical Group, Rancho Cucamonga
Wilshire Onc Med Grp., Inc, Glendora
Wilshire Oncology Medical Group, La Verne
Wilshire Oncology Medical Group, Pasadena
Wilshire Oncology Medical Group, Pomona
Wilshire Oncology Medical Group, West Covina
Central Hematology Oncology Medical Group Inc., Alhambra
Kaiser Permanente San Diego; Hepatology Research, San Diego
Compassionate Cancer Care, Fountain Valley
Pacific Coast Hematology/Oncology Medical Group, Fountain Valley
Pacific Cancer Medical Center, Anaheim
St. Jude Heritage Healthcare; Virgiia K.Crosson Can Ctr, Fullerton
Wilshire Oncology Medical Group, Corona
Ventura County Hematology-Oncology Specialists, Oxnard
Sansum Santa Barbara Medical Foundation Clinic, Santa Barbara
Santa Barbara Hematology Oncology Medical Group, Inc., Santa Barbara
Comprehensive Blood/Cancer Ctr, Bakersfield
K. Permanente - San Fransisco, San Francisco
Bay Area Cancer Research Group, LLC, Pleasant Hill
Kaiser Permanente - Vallejo, Vallejo
K. Permanente - Walnut Creek, Walnut Creek
Kaiser Permanente - Oakland, Oakland
South Bay Oncology Hematology Partners, Campbell
K. Permanente - San Jose, San Jose
Sutter Gould Medical Foundation; Clinical Research, Modesto
UC Davis Cancer Center; Oncology, Sacramento
Northwest Medical Specialties, Tacoma
St. Mary Medical Center, Walla Walla
Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou
Blokhin Cancer Research Center; Combined Treatment, Moscow
Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy, Moscow
National University Hospital; National University Cancer Institute, Singapore (NCIS), Singapore
Jilin Cancer Hospital, Changchun
Ivanovo Regional Oncology Dispensary, Ivanovo
National Cancer Centre; Medical Oncology, Singapore
SBI of Healthcare Leningrad Regional Oncology Dispensary, Saint Petersburg
"FSBINational Medical Research Center of Oncology named after N.N.Petrov MHRF", Saint Petersburg
Shanghai First People's Hospital, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Regional Oncology Hospital Of Kursk; Chemotherapy, Kislino, Kursk Region
Zhejiang Cancer Hospital, Hangzhou
SBI of Healthcare Samara Regional Clinical Oncology Dispensary, Samara
State Inst. Of Healthcare Orenburg Regional Clinical Oncology Dis, Orenburg
Omsk Region Clinical Oncology Dispensary; 1St Sergical Department, Omsk
Northwest Oncology/ Hematology Assoc., Coral Springs
Florida Cancer Specialists - Fort Myers (New Hampshire Ct), Fort Myers
Lakeland Regional Cancer Center, Lakeland
Central GA Cancer Care, Warner Robins
Cancer Center of Kansas, Wichita
Christus Schumpert Health System, Shreveport
Boston Medical Center, Boston
Berkshire Hematology, Oncology Pc, Pittsfield
Minneapolis Oncology Hamatology PA, Minneapolis
Dartmouth Hitchcock Medical Center, Lebanon
St. Barnabas Cancer Center, Livingston
Oncology and Hematology Specialists, Mountain Lakes
Community Cancer Center Rutland Regional Medical Center, Rutland
Centro de Oncologia e Investigacion Buenos Aires (COIBA), Buenos Aires
Policlinica Privada Site la Plata SA; Oncology, La Plata
Unidad Oncológica De Neuquén, Neuquén
Hosp Provincial D. Centenarios; Oncology Dept, Rosario
Crio - Centro Regional Integrado de Oncologia, Fortaleza
Clinica Amo - Assistencia Medica Em Oncologia, Salvador
Centro Goiano de Oncologia - CGO, Goiânia
Instituto Nacional de Cancer - INCa; Oncologia, Rio de Janeiro
Hospital Universitario Clementino Fraga Filho - UFRJ; Oncologia, Rio de Janeiro
Hospital de Caridade de Ijui; Oncologia, Ijuí
Santa Casa de Misericordia de Porto Alegre, Porto Alegre
Hospital das Clinicas - UFRGS, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
Hospital Amaral Carvalho, Jaú
Hospital das Clinicas - FMUSP Ribeirao Preto, Ribeirão Preto
Faculdade de Medicina do ABC - FMABC; Oncologia e Hematologia, Santo André
Iso - Inst. Santista de Oncologia, Santos
Instituto do Cancer Arnaldo Vieira de Carvalho - ICAVC; Pesquisa Clinica, São Paulo
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Hospital Perola Byington, São Paulo
Inst. Brasileiro de Controle Ao Cancer; Oncologia Clinica / Quimioterapia, São Paulo
Hospital Estadual do Servidor Publico, São Paulo
Instituto de Oncologia de Sorocaba - CEPOS, Sorocaba
St. Michael'S Hospital, Toronto
Solca Guayaquil- Sociedad de Lucha Contra El Cáncer; Oncology, Guayaquil
Teodoro Maldonado Carbo Hospital; Oncology Service, Guayaquil
Hospital Solca Quito; Oncologia, Quito
Centre Antoine Lacassagne; Hopital De Jour A2, Nice
Universitätsklinikum Halle (Saale); Universitätsklinik Und Poliklinik Für Gynäkologie, Halle
Centro Oncologico S.A., Guatemala City
Grupo Angeles, Guatemala City
Therapeutic Research Inst. & Lab S.A. (Trial), Guatemala City
Pamela Youde Nethersole Eastern Hospital; Clinical Oncology, Hong Kong
Prince of Wales Hosp; Dept. Of Clinical Onc, Shatin
Ausl Frosinone - Ospedale Umberto I; Divisione Di Oncologia, Frosinone
Aichi Cancer Center Hospital, Breast Oncology, Aichi
Chiba Cancer Center; Breast Surgical Oncology, Chiba
National Cancer Center Hospital East; Breast and Medical Oncology, Chiba
Natl Hosp Org Shikoku; Cancer Ctr, Surgery, Ehime
Kitakyushu Municipal Medical Center, Surgery, Fukuoka
National Hospital Organization Kyushu Cancer Center;Breast Oncology, Fukuoka
Gunma University Hospital; Department of Thoracic and Visceral Organ Surgery, Gunma
Sagara Hospital; Breast Surgery, Kagoshima
St. Marianna University School of Medicine Hospital, Breast and Endocrine Surgery, Kanagawa
Tokai University Hospital, Breast and Endocrine Surgery, Kanagawa
Kumamoto City Hospital, Breast and Endocrine Surgery, Kumamoto
Kumamoto Shinto General Hospital; Breast Cancer Center, Kumamoto
Kyoto University Hospital; Breast Surgery, Kyoto
Niigata Cancer Ctr Hospital; Breast Surgery, Niigata
Iwate Med Univ School of Med; Surgery, Numakunai
OSAKA CITY GENERAL HOSPITAL;Medical Oncology, Osaka
National Hospital Organization Osaka National Hospital; Breast Surgery, Osaka
Osaka University Hospital; Breast and Endocrine Surgery, Osaka
Saitama Medical University International Medical Center; Medical Oncology, Saitama
Saitama Cancer Center, Breast Oncology, Saitama
Shizuoka Cancer Center; Female Internal Medicine, Shizuoka
Shizuoka General Hospital; Breast Surgery, Shizuoka
Jichi Medical University; Dept of Clinical Oncology, Tochigi
National Cancer Center Hospital; Breast and Medical Oncology, Tokyo
St. Luke's Internat. Hospital, Breast Surgical Oncology, Tokyo
Tokyo Metropolitan; Komagome Hospital, Surgery, Tokyo
The Cancer Inst. Hosp. of JFCR; Breast Oncology Center, Tokyo
Tokyo Medical Uni. Hospital; Breast Oncology, Tokyo
Rigas Austrumu Kliniska Universitates slimnica, Latvijas Onkologijas centrs, Riga
P.Stradins Clinical University Hospital, Oncology Centre, Riga
Hospital Angeles Metropolitano; Room 220, Mexico City
Samodzielny Publiczny Kliniczny Nr 1 W Lublinie; Klinika Chirurgii Onkologicznej, Lublin
COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej, Lublin
Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu, Poznan
Zachodniopomorskie Centrum Onkologii, Osrodek Innowacyjnosci, Rozwoju i Badan Klinicznych, Szczecin
Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Klinika Nowotworów Piersi i Chirurgii, Warsaw
National Cancer Center; Medical Oncology, Gyeonggi-do
Seoul National Uni Hospital; Dept. of Internal Medicine/Hematology/Oncology, Seoul
Yonsei Uni College of Medicine, Severance Hospital; Internal Medicine Dept., Seoul
Samsung Medical Centre; Division of Hematology/Oncology, Seoul
Asan Medical Center, Uni Ulsan Collegemedicine; Dept.Internal Medicine / Divisionhematology/Oncology, Seoul
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona
Hospital Duran i Reynals; Oncologia, Barcelona
Broomfield Hospital; Oncology, Chelmsford
St James Uni Hospital; Icrf Cancer Medicine Research Unit, Leeds
Leicester Royal Infirmary; Dept. of Medical Oncology, Leicester
St. Bartholomew'S Hospital; Dept of Medical Oncology, London
Royal Free Hospital; Dept of Oncology, London
St George'S Hospital; Oncology Research Office /Oncology Opd, London
Charing Cross Hospital; Medical Oncology., London
The Clatterbridge Cancer Ctr For Oncolgy, Metropolitan Borough of Wirral
Mount Vernon Hospital; Centre For Cancer Treatment, Northwood
Royal Cornwall Hospital; Dept of Clinical Oncology, Truro
Southend Hospital; Oncology Dept, Westcliffe-on-sea
Lead Sponsor
Hoffmann-La Roche
INDUSTRY
Genentech, Inc.
INDUSTRY