554
Participants
Start Date
March 31, 2008
Primary Completion Date
April 30, 2011
Study Completion Date
December 31, 2016
Memantine
Patients began taking memantine(by mouth) while receiving radiation therapy. Patients continued taking memantine for 24 weeks or until doctor thinks it is in their best interest to stop. They started with 5 mg once a day. After a week dose increased to 5 mg twice a day. At week 3, dose increased to 10 mg in the morning and 5 mg in the evening. Weeks 4-24, dose was 10 mg twice a day.
Placebo
Patients began taking placebo(by mouth) while receiving radiation therapy. Patients continued taking placebo for 24 weeks or until doctor thinks it is in their best interest to stop. They started with 5 mg once a day. After a week dose increased to 5 mg twice a day. At week 3, dose increased to 10 mg in the morning and 5 mg in the evening. Weeks 4-24, dose was 10 mg twice a day.
Whole brain radiation therapy
Whole brain radiation therapy (WBRT) once a day (2.5Gy), five days a week (Monday to Friday) for three weeks, for total fifteen treatments and 37.5 Gy
CCOP - North Shore University Hospital, Manhasset
Long Island Jewish Medical Center, New Hyde Park
New York Methodist Hospital, Brooklyn
New York Oncology Hematology, PC at Albany Regional Cancer Care, Albany
Veterans Affairs Medical Center - Albany, Albany
Sands Cancer Center, Canandaigua
Highland Hospital of Rochester, Rochester
Lipson Cancer and Blood Center at Rochester General Hospital, Rochester
University Radiation Oncology at Parkridge Hospital, Rochester
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
UPMC Cancer Center at Beaver Medical Center, Beaver
UPMC Cancer Center at Jefferson Regional Medical Center, Clairton
UPMC Cancer Center - Natrona Heights, Natrona Heights
UPMC - Moon, Moon Township
UPMC Cancer Center at UPMC McKeesport, McKeesport
UPMC Cancer Center at Magee-Womens Hospital, Pittsburgh
UPMC Cancer Center at UPMC St. Margaret, Pittsburgh
UPMC Cancer Center at UPMC Passavant, Pittsburgh
UPMC Cancer Center - Upper St. Clair, Pittsburgh
Washington Hospital Cancer Center, Washington
UPMC Cancer Center - Uniontown, Uniontown
UPMC Cancer Center - Arnold Palmer Pavilion, Greensburg
UPMC Cancer Center at the John P. Murtha Pavilion, Johnstown
Jameson Memorial Hospital - North Campus, New Castle
Cancer Center at Clarion Hospital, Clarion
UPMC Cancer Center at UPMC Northwest, Seneca
Adams Cancer Center, Gettysburg
Cherry Tree Cancer Center, Hanover
York Cancer Center at Apple Hill Medical Center, York
St. Luke's Cancer Network at St. Luke's Hospital, Bethlehem
Northeast Radiation Oncology Center, Dunmore
Rosenfeld Cancer Center at Abington Memorial Hospital, Abington
Bryn Mawr Hospital, Bryn Mawr
Delaware County Regional Cancer Center at Delaware County Memorial Hospital, Drexel Hill
Lankenau Cancer Center at Lankenau Hospital, Wynnewood
Albert Einstein Cancer Center, Philadelphia
CCOP - Christiana Care Health Services, Newark
Washington Cancer Institute at Washington Hospital Center, Washington D.C.
Central Maryland Oncology Center, Columbia
Tate Cancer Center at Baltimore Washington Medical Center, Glen Burnie
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
Cancer Institute at St. Joseph Medical Center, Towson
St. Agnes Hospital Cancer Center, Baltimore
Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center, Baltimore
Good Samaritan Hospital of Maryland, Baltimore
University of Virginia Cancer Center, Charlottesville
Sentara Cancer Institute at Sentara Norfolk General Hospital, Norfolk
Schiffler Cancer Center at Wheeling Hospital, Wheeling
New Hanover Radiation Oncology, PA, Wilmington
Mission Hospitals - Memorial Campus, Asheville
CCOP - Upstate Carolina, Spartanburg
Hollings Cancer Center at Medical University of South Carolina, Charleston
Veterans Affairs Medical Center - Atlanta (Decatur), Decatur
Winship Cancer Institute of Emory University, Atlanta
Northeast Georgia Medical Center, Gainesville
John B. Amos Cancer Center, Columbus
Integrated Community Oncology Network - Orange Park, Orange Park
Flagler Cancer Center, Saint Augustine
Florida Cancer Center - Palatka, Palatka
Baptist Cancer Institute - Jacksonville, Jacksonville
Integrated Community Oncology Network at Southside Cancer Center, Jacksonville
Integrated Community Oncology Network, Jacksonville Beach
Baptist Medical Center South, Jacksonville
Florida Institute of Research, Medicine and Surgery Cancer Center, Orlando
MBCCOP - Gulf Coast, Mobile
Providence Cancer Center at Providence Hospital, Mobile
Regional Cancer Center at Singing River Hospital, Pascagoula
Norton Suburban Hospital, Louisville
Flower Hospital Cancer Center, Sylvania
Medical University of Ohio Cancer Center, Toledo
St. Charles Mercy Hospital, Oregon
CCOP - Toledo Community Hospital, Toledo
St. Anne Mercy Hospital, Toledo
Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland
Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights
Cleveland Clinic Cancer Center, Independence
Cleveland Clinic Taussig Cancer Center, Cleveland
Barberton Citizens Hospital, Barberton
McDowell Cancer Center at Akron General Medical Center, Akron
Cancer Care Center, Incorporated, Salem
Cancer Treatment Center, Wooster
Cleveland Clinic - Wooster, Wooster
North Coast Cancer Care, Incorporated, Sandusky
Precision Radiotherapy at University Pointe, West Chester
Charles M. Barrett Cancer Center at University Hospital, Cincinnati
Saint John's Cancer Center at Saint John's Medical Center, Anderson
Methodist Cancer Center at Methodist Hospital, Indianapolis
Central Indiana Cancer Centers - East, Indianapolis
Community Regional Cancer Care at Community Hospital East, Indianapolis
Community Regional Cancer Care at Community Hospital North, Indianapolis
Center for Cancer Care at Goshen General Hospital, Goshen
CCOP - Northern Indiana CR Consortium, South Bend
Radiation Oncology Associates Southwest, Fort Wayne
Parkview Regional Cancer Center at Parkview Health, Fort Wayne
Bloomington Hospital Regional Cancer Institute, Bloomington
William Beaumont Hospital - Royal Oak Campus, Royal Oak
St. Mary Mercy Hospital, Livonia
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit
Charach Cancer Center at Huron Valley - Sinai Hospital, Commerce
Great Lakes Cancer Institute at McLaren Regional Medical Center, Flint
CCOP - Grand Rapids, Grand Rapids
Community Memorial Hospital Cancer Care Center, Menomonee Falls
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center, Milwaukee
Medical College of Wisconsin Cancer Center, Milwaukee
West Allis Memorial Hospital, West Allis
All Saints Cancer Center at Wheaton Franciscan Healthcare, Racine
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau
Franciscan Skemp Healthcare - La Crosse Campus, La Crosse
Theda Care Cancer Institute, Appleton
United Hospital, Saint Paul
Minnesota Oncology Hematology, PA - Maplewood, Maplewood
Fairview Ridges Hospital, Burnsville
Ridgeview Medical Center, Waconia
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis
CCOP - Metro-Minnesota, Saint Louis Park
Mercy and Unity Cancer Center at Unity Hospital, Fridley
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Mayo Clinic Cancer Center, Rochester
Immanuel St. Joseph's, Mankato
Albert Lea Cancer Center at Albert Lea Medical Center, Albert Lea
CentraCare Clinic - River Campus, Saint Cloud
Rapid City Regional Hospital, Rapid City
Trinity CancerCare Center, Minot
CCOP - Montana Cancer Consortium, Billings
Northern Rockies Radiation Oncology Center, Billings
Northwest Community Hospital, Arlington Heights
CCOP - Carle Cancer Center, Urbana
Cancer Institute at St. John's Hospital, Springfield
CCOP - St. Louis-Cape Girardeau, St Louis
Kansas City Cancer Centers - South, Kansas City
Kansas City Cancer Centers - North, Kansas City
Hulston Cancer Center at Cox Medical Center South, Springfield
Kansas City Cancer Centers - Southwest, Overland Park
Methodist Estabrook Cancer Center, Omaha
Nebraska Medical Center, Omaha
Oklahoma University Cancer Institute, Oklahoma City
Texas Oncology, PA at Texas Cancer Center - Sherman, Sherman
Medical City Dallas Hospital, Dallas
Texas Oncology, PA at Texas Cancer Center Dallas Southwest, Dallas
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas
Longview Cancer Center, Longview
Tyler Cancer Center, Tyler
Texas Oncology, PA at Texas Cancer Center - Arlington South, Arlington
Texas Oncology, PA at Harris Center HEB, Bedford
Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital, Fort Worth
Texas Oncology, PA at Texas Cancer Center - Denton South, Denton
Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land, Sugar Land
Cancer Care Centers of South Texas - Northeast, San Antonio
West Texas Cancer Center, Odessa
Rocky Mountain Cancer Centers - Aurora, Aurora
Poudre Valley Radiation Oncology, Fort Collins
Rocky Mountain Cancer Centers - Colorado Springs, Colorado Springs
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City
Huntsman Cancer Institute at University of Utah, Salt Lake City
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden
Dixie Regional Medical Center - East Campus, St. George
Arizona Oncology Services Foundation, Phoenix
Arizona Oncology - Tucson, Tucson
Lovelace Medical Center - Downtown, Albuquerque
Radiation Oncology Associates, PA, Albuquerque
CCOP - Nevada Cancer Research Foundation, Las Vegas
Renown Institute for Cancer at Renown Regional Medical Center, Reno
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles
Glendale Adventist Medical Center, Glendale
Providence Saint Joseph Medical Center - Burbank, Burbank
St. Joseph Hospital Regional Cancer Center - Orange, Orange
John Muir/Mt. Diablo Comprehensive Cancer Center, Walnut Creek
Emanuel Regional Cancer Services at Emanuel Medical Center, Turlock
Auburn Radiation Oncology, Auburn
Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael
Radiation Oncology Center - Roseville, Roseville
Radiation Oncology Centers - Cameron Park, Cameron Park
Solano Radiation Oncology Center, Vacaville
Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento
University of California Davis Cancer Center, Sacramento
Mercy General Hospital, Sacramento
Enloe Cancer Center at Enloe Medical Center, Chico
Willamette Valley Cancer Center - Eugene, Eugene
Dubs Cancer Center at Rogue Valley Medical Center, Medford
Providence Cancer Center at PMCC, Medford
Three Rivers Community Hospital, Grants Pass
CCOP - Virginia Mason Research Center, Seattle
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
Cancer Care Northwest - Spokane South, Spokane
Mayo Clinic Scottsdale, Scottsdale
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson
Cancer Care Center at John Muir Health - Concord Campus, Concord
City of Hope Comprehensive Cancer Center, Duarte
Rebecca and John Moores UCSD Cancer Center, La Jolla
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles
Stanford Cancer Center, Stanford
Yale Cancer Center, New Haven
University of Florida Shands Cancer Center, Gainesville
John H. Stroger, Jr. Hospital of Cook County, Chicago
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Cancer Center at Ball Memorial Hospital, Muncie
Holden Comprehensive Cancer Center at University of Iowa, Iowa City
Lucille P. Markey Cancer Center at University of Kentucky, Lexington
Boston University Cancer Research Center, Boston
Barbara Ann Karmanos Cancer Institute, Detroit
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale
Billings Clinic - Downtown, Billings
Payson Center for Cancer Care at Concord Hospital, Concord
Elliot Regional Cancer Center at Elliot Hospital, Manchester
Cancer Institute of New Jersey at Cooper University Hospital - Camden, Camden
Trinitas Comprehensive Cancer Center at Trinitas Hospital, Elizabeth
Princeton Radiation Oncology Center, Jamesburg
Ocean Medical Center at Meridian Health, Laurelton
Saint Peter's University Hospital, New Brunswick
University Medical Center at Princeton, Princeton
J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River
Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township
University of New Mexico Cancer Center, Albuquerque
Roswell Park Cancer Institute, Buffalo
Summa Center for Cancer Care at Akron City Hospital, Akron
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus
Northwest Ohio Oncology Center, Maumee
Geisinger Cancer Institute at Geisinger Health, Danville
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia
Fox Chase Cancer Center - Philadelphia, Philadelphia
UPMC - Shadyside, Pittsburgh
University of Texas Health Science Center at San Antonio, San Antonio
Fletcher Allen Health Care - University Health Center Campus, Burlington
St. Vincent Hospital Regional Cancer Center, Green Bay
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison
Nova Scotia Cancer Centre, Halifax
London Regional Cancer Program at London Health Sciences Centre, London
Maisonneuve-Rosemont Hospital, Montreal
Hopital Notre-Dame du CHUM, Montreal
McGill Cancer Centre at McGill University, Montreal
Centre Hospitalier Universitaire de Quebec, Québec
Collaborators (1)
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK