Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping

PHASE3CompletedINTERVENTIONAL
Enrollment

1,157

Participants

Timeline

Start Date

December 14, 2007

Primary Completion Date

June 15, 2010

Study Completion Date

July 13, 2010

Conditions
Aneurysmal Subarachnoid Hemorrhage
Interventions
DRUG

Clazosentan

Intravenous clazosentan administered by continuous infusion at 5 mg/h

DRUG

Placebo

Placebo administered by continuous infusion matching clazosentan administration

Trial Locations (117)

1000

Clinical Hospital Dubrava, Zagreb

University Hospital Sestre Milosrdnice, Zagreb

1090

AKH University of Vienna, Medical University, Vienna

1200

Cliniques Universitaires Saint-Luc, Universite Catholique de, Brussels

1211

Geneva University Hospital, Geneva

1220

Sozialmedizinisches Zentrum Ost (ZMZ-Ost) Donauspital Vienna, Vienna

2000

General Hospital Maribor, Maribor

2100

Copenhagen University Hospital, Copenhagen

2600

Copenhagen Country Hospital, Glostrup Municipality

3010

Universitatsklinik Bern, Bern

Universitätsklinik Bern Klinik für Neurochirurgie, Bern

4029

Royal Brisbane Hospital, Herston

5000

Odense University Hospital, Odense

5001

Kantonsspital Aarau, Aarau

5020

University Fur Neurochirurgie, SALK, Christian Doppler Hospital, Salzburg

5021

Haukeland University Hospital Helse Bergen HF, Bergen

6020

Medizinsche Universitat, Innsbruck

6807

Landeskrankenhaus, Feldkirch

8036

Landeskrankenhaus und Medizinische Universitat Graz, Graz

8091

Universitatsspital Zurich, Zurich

9007

Kantonsspital St. Gallen, Sankt Gallen

10000

"Clinical Hospital Dubrava", Zagreb

10032

Columbia University Medical Center, New York

13385

Hopital de la Timone, Marseille

15030

Na Homolce Hospital Prague, Prague

16902

UVN Prague, Prague

18000

Clinical Center Nis, Niš

19107

Thomas Jefferson University School of Medicine-Jefferson Hospital for Neuroscience, Philadelphia

20162

Ospedale Niguarda, Milan

20246

University Hospital of Hamburg, Hamburg

21000

Clinical Center Novi Sad, Novi Sad

22185

Lund University Hospital, Lund

22908

University of Virginia Health System-Department of Neurosurgery, Charlottesville

23284

Virginia Commonwealth University-Department of Neurosurgery, Richmond

28041

Hospital Universitario 12 de Octubre, Madrid

33076

Hopital Pellegrin, Bordeaux

33521

Tampere University Central Hospital, Tampere

34390

Istanbul Universitesi, Istanbul Tip, Istanbul

35100

Ege Universitesi Tip Fak Hestanesi, Bornova

35128

Ospedale Civile di Padova, Padua

37087

Nemocnice Ceske Budejovice, České Budějovice

37126

Ospedale Civile Borgo Trento, Verona

40139

Ospedale Bellaria-Maggiore Hospital, Bologna

41100

Nuovo Ospedale Sant' Agostino Estense, Modena

41345

Sahlgrenska, Gothenburg

43100

Azienda Ospedaliero-Universitaria di, Parma

44106

University Hospitals Case Medical Center-Department of Neurosurgery, Cleveland

45147

University of Hospital of Essen, Essen

45219

University of Cincinnati-Department of Neurosurgery, Cincinnati

47023

Ospedale Maurizio Bufalini, Cesena

49933

Pole d'Anesthesie Reanimation, CHU D'Angers, Angers

50141

Azienda Ospedaliero-Universitaria di Careggi, Florence

51000

Guangdong Province Chinese Medicine Hospital, Guangzhou

53105

University of Bonn Medical Center, Bonn

60528

Universitatsklinik Frankfurt, Klinik und Poliklinik fur Neurochirurgie, Frankfurt

62500

Faculty Hospital/FN Brno Bohunice, Brno

63003

Chu Hopital Gabriel Montpied, Clermont-Ferrand

69120

Neurochirurggische Universitatsklinik des Heidelberg, Heidelberg

69677

Hopital Neurologique et Neuro-Chirurgical Pierre Wertheimer, Bron

75185

Uppsala University Hospital-Uppsala Akademiska Sjukhus, Uppsala

80211

Katedra Klinika Neurochirurgii Akademii Medycznej w Gdansku, Gdansk

81377

University Munich Groshadern, Munich

81675

Thechnical University-Klinikum rechts der Isar, Munich

85013

Barrow Neurosurgical Associates, Phoenix

91054

University of Erlangen-Nurnberg, Erlangen

93053

University Regensburg, Regensburg

97239

Oregon Health & Science University-Oregon Stroke Center, Portland

100050

Beijing Tian Tan Hospital, Beijing

110011

All India Insititute of Medicla Sciences (AIIMS), New Delhi

160012

Post Graduate Institute of Medical Education and Research, Chandigarh

Post Graduate Institute of Medical Education, Chandigarh

200040

Shanghai Hua Shan Hospital, Shanghai

308433

National Neuroscience, Singapore

411005

Sahyadri Hospital, Pune

430030

Wuhan Tongji Hospital, Wuhan

500482

Nizam's Institute of Medical Sciences, Hyderabaad

510080

1st Affilated Hospital of Zhongshan, Guangzhou

80113-2769

Colorado Neurological Institute, Englewood

02114

Massachusetts General Hospital, Boston

11794-8122

State University of New York at Stony Brook-Health Sciences Center, Stony Brook

VIC 3004

The Alfred Hospital, Melbourne

T6G2B7

University of Alberta Hospital, Edmonton

V5Z 1 M9BC

Vancouver Hospital, Vancouver

M5C367

St Michael's Hospital, University, Toronto

H2L4M1

CHUM Notre Dame, Montreal

T2N2T9AB

University of Calgary Foothills Medical Center, Calgary

B3H3A7

QEII Health Science Center, Halifax

M5T2S8

Toronto Western Hospital, University of Toronto, Toronto

100053 PR

XuanWu Hospital Institute of Brain Vascular Disease, Beijing

Fin-00029HUS

Helsinki University Central Hospital, Helsinki

90029OYS

Oulu University Hospital, Oulu

D-13353

Charite Universitatsmedizin Berlin-Neurochirurgische Klinik-CVK, Berlin

01307

Klinik und Poliklinik fur Neurochirurgie, Dresden

04103

Klinik und Poliklinik fur Neurochirurgie, Leipzig

NT

Prince of Wales Hospital, Hong Kong

Unknown

Queen Mary Hospital, Hong Kong

Klinika Neurochirurgii AMB-Neurosurgery Clinic of Medical Academy, Bialystok

411 004

Sahyadri Specialty Hospital, Pune

LV-1038

Riga Eastern Clinical University Hospital, Riga

Auckland

Auckland Hospital, Grafton

0407

Ulleval University Hospital, Oslo

N9038

Universitetssykehuset Nord-Norge, Tromsø

85-094

Kathedra I Klinika Neurochirurghii I Neurotraumatologii Collegium Medicum im. L. Rydygiera w Bydgoszc, Bydgoszcz

40-752

Samodzielny Publiczny Szpital Kliniczny Slaskiej Akademii Medycznej w Katowicach, Katowice

31-503

Oddzial Kliniczny Kliniki Neurochirurgii i Neurotrumatologii Szpitala, Uniwersyteckiego w Krakowie, Krakow

90-153

Katedra Neurochirurgii, Uniwersytet, Lodz

20-090

Katedra I Klinika Neurochirurgii i Dzieciecej, Lublin

02-097

Katedra IKlinika Neurochirurgii Akademii Medycznej w Warszawie Clinic, Warsaw

125 047

Scientific Research Institute of Neurosurgery by Burdenko, Moscow

700-721

Kyungpook National University, Daegu

302-799

Daejeon Eulji University Hospital, Daejeon

08003

Hospital Del Mar, Barcelona

08035

Vall d'Hebron Hospital, Barcelona

07014

Hospital de Son Dureta, Palma de Mallorca

06100

Ibn-i Sina Hastanesi Ankara & Ankara Universitesi Tip Fakultesi, Ankara

49,005

Regional Clinical Hospital by Mechnikov, Dnipropetrovsk

04 050

A. P. Romodanov Institute of Neurosurgery, Kiev

Sponsors
All Listed Sponsors
lead

Idorsia Pharmaceuticals Ltd.

INDUSTRY