Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 30, 2007

Primary Completion Date

August 31, 2008

Study Completion Date

August 31, 2008

Conditions
Fungal Keratitis
Interventions
DRUG

Natamycin 5%

One drop of medication will be given every one hour while awake for one week. For another 2 weeks, one drop of medication should be given every 2 hours while awake

DRUG

Voriconazole

"Voriconazole (VFEND® I.V., Pfizer, New York, NY) will be prepared as a 1% solution.~One drop of medication should be given every one hour while awake for one week. For another 2 weeks, one drop of medication should be given every 2 hours while awake"

PROCEDURE

Corneal de-epithelialization

Corneal de-epithelialization at 1 week and 2 weeks from enrollment to increase epithelial penetration of antifungal medications.

Trial Locations (2)

Unknown

Aravind Eye Hospital, Madurai

Aravind Eye Hospital, Pondicherry

All Listed Sponsors
collaborator

That Man May See, Inc.

OTHER

collaborator

Aravind Eye Hospitals, India

OTHER

collaborator

Dartmouth-Hitchcock Medical Center

OTHER

lead

University of California, San Francisco

OTHER

NCT00557362 - Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer | Biotech Hunter | Biotech Hunter