Belatacept in Liver Transplant Recipients

PHASE2TerminatedINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

January 31, 2008

Primary Completion Date

March 31, 2010

Study Completion Date

June 30, 2011

Conditions
Immunosuppression in Solid Organ Transplant
Interventions
DRUG

Tacrolimus

Capsules, Oral, dosed to achieve 12 hour trough level of 6-12 ng/mL, twice daily, 52 weeks (Short Term \[ST\]), in accordance with local practice and the package insert, 4 years (Long-Term Extension \[LTE\])

DRUG

Basiliximab

Intravenous (IV), 20 mg, Day1 and Day 5

DRUG

Belatacept More Intensive (MI)

"Intravenous (IV),~10 mg/kg on Days 1, 3 and 5, and at Weeks 2, 4, 6, 8, 10, 12, 16, 20, and 24.~After 6 months (24 weeks) 5 mg/kg, every 4 weeks, 52 weeks (Short term \[ST\]), 5 mg/kg, every 4 weeks, 4 years (Long-term extension \[LTE\])"

DRUG

Belatacept Less Intensive (LI)

"Intravenous (IV),~10 mg/kg on Days 1, 3 and 5, and at Weeks 2, 4, 8 and 12.~After 3 months (12 weeks) 5 mg/kg, every 4 weeks, 52 weeks (Short term \[ST\]), 5 mg/kg, every 4 weeks, 4 years (Long-Term Extension(LTE)"

DRUG

Mycophenolate Mofetil (MMF)

Intravenous (IV)/Capsules, IV/Oral, 1-2g/day, 52 weeks (Short term \[ST\]), ≤ 1 g/day, 4 years (Long-term extension \[LTE\])

Trial Locations (42)

1090

Local Institution, Vienna

10016

Nyu School Of Medicine, New York

10595

Westchester Medical Center, Valhalla

13353

Local Institution, Berlin

19104

Hospital Of The University Of Pennsylvania, Philadelphia

20246

Local Institution, Hamburg

21041

Local Institution, Rio de Janeiro

24128

Local Institution, Bergamo

28203

Carolinas Medical Center, Charlotte

30322

Emory University Hospital, Atlanta

30625

Local Institution, Hanover

31059

Local Institution, Toulouse

32224

Mayo Clinic Transplant Department, Jacksonville

33606

Lifelink Healthcare Institute, Tampa

34295

Local Institution, Montpellier

35128

Local Institution, Padua

45267

Univ. Of Cin. Coll. Of Med., Cincinnati

48202

Henry Ford Hospital, Detriot

53226

Froedtert Memorial Lutheran Hospital, Milwaukee

55455

University Of Minnesota, Minneapolis

56124

Local Institution, Pisa

60611

Northwestern University Feinberg School Of Medicine, Chicago

63110

Washington University School Of Medicine, St Louis

69120

Local Institution, Heidelberg

69437

Local Institution, Lyon

70112

Tulane Center For Abdominal Transplant, New Orleans

72076

Local Institution, Tübingen

73112

Integris-Baptist Medical Ctr., Oklahoma City

75014

Local Institution, Paris

75246

Baylor University Medical Center, Dallas

80060

Local Institution, Curitiba

85054

Mayo Clinic Hospital, Phoenix

90020

Local Institution, Centro-Porto Alegre

90033

Usc University Hospital, Los Angeles

92118

Local Institution, Clichy

94143

University Of California San Francisco Medical Center, San Francisco

94800

Local Institution, Villejuif

C1181ACH

Local Institution, Ciudad de Buenos Aires

T6G 2B7

Local Institution, Edmonton

M5G 2N2

Local Institution, Toronto

00168

Local Institution, Roma

08036

Local Institution, Barcelona

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY