Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

4,884

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

April 30, 2018

Study Completion Date

May 15, 2019

Conditions
Breast Cancer
Interventions
DRUG

Letrozole

Film-coated tablet, oral use, 2.5 mg Letrozole daily for 5 years continuously

DRUG

Letrozole

Film-coated tablet, oral use, 2.5 mg daily, 48 months over 5 yrs: 4 x 9 months (9 mo followed by 3 mo treatment-free interval in yrs 1-4, -\> 36 mo) plus 1 x 12 mo in yr 5 -\> 48 months

Trial Locations (164)

1

Christchurch Hospital, Christchurch

29

Fundacion Arturo Lopez Perez, Santiago

34

Instituto Nacional de Enfermedades Neoplasicas, Lima

1000

Institut Jules Bordet, Brussels

1090

Medical University of Vienna, Vienna

Academisch Ziekenhuis der Vrije Universiteit Brussel, Brussels

1122

National Institute of Oncology - Budapest, Budapest

1200

Cliniques Universitaires Saint-Luc, Brussels

1708

Kantonsspital Freiburg, Fribourg

2005

Hospital Santiago Oriente Dr. Luis Tisne Brousse, Peñalolén

2020

Waikato Hospital, Hamilton

2031

Prince of Wales Private Hospital, Randwick

2139

Concord Repatriation General Hospital, Concord

2199

Sandton Oncology Medical Research, Sandton

2200

Bankstown - Lidcombe Hospital, Bankstown

2290

Breast Center, Gateshead

2300

Sint-Elisabethziekenhuis, Turnhout

2310

Calvary Mater Newcastle, Waratah

2340

Tamworth Base Hospital, Tamworth

2350

Armidale Hospital, Armidale

2444

Port Mcquarie Base Hospital, Port Macquarie

2485

Tweed Heads Hospital, Tweed Heads

2570

Algemeen Ziekenhuis Sint-Maarten - Campus Rooiberg, Duffel

2576

Southern Highlands Cancer Center, Bowral

2820

Imelda vzw, Ziekenhuis, Bonheiden

2930

AZ Klina, Brasschaat

3002

Peter MacCallum Cancer Centre, East Melbourne

3084

Austin Health, Heidelberg

3128

Box Hill Hospital, Box Hill

3135

Maroondah Hospital, Melbourne

3400

Hillerod Hospital, Hillerød

3500

Virga Jesse Hospital, Hasselt

3600

Regionalspital, Thun

3700

Bornholms Hospital, Rønne

4000

Centre Hospitalier Regional de la Citadelle, Liège

Clinique Saint Vincent, Rocourt

Roskilde Amtssygehuset, Roskilde

4500

Centre Hospitalier Hutois, Huy

4600

Klinikum Kreuzschwestern Wels GmbH, Wels

4700

Naestved Hospital, Næstved

6000

Royal Perth Hospital, Perth

6400

Sonderborg Sygehus, Sønderborg

6600

Lago Maggiore Oncology Foundation, Locarno

"Ospedale la Carita, Locarno", Locarno

6700

Cliniques du Sud Luxembourg, Arlon

6800

Centre Hospitalier de l'Ardenne, Libramont

7000

Royal Hobart Hospital, Hobart

7100

Hopital de Jolimont, Haine-Saint-Paul

7320

North West Regional Hospital, Burnie

7505

Tygerberg Hospital, Cape Town

8400

AZ Damiaan, Ostend

8500

AZ Groeninge - Oncologisch Centrum, Kortrijk

8501

Brustzentrum Thurgau at Kantonsspital Frauenfeld, Frauenfeld

8800

Viborg Sygehus, Viborg

9100

AZ Nikolaas - Sint-Niklaas, Sint-Niklaas

9500

LKH Villach, Villach

13900

Ospedale degli Infermi - ASL 12, Biella

20141

European Institute of Oncology, Milan

21100

Ospedale di Circolo e Fondazione Macchi, Varese

25123

Spedali Civili di Brescia, Brescia

26100

Azienda Istituti Ospitalieri, Cremona

28033

M. D. Anderson International Espana SA, Madrid

28034

Hospital Ramon y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

29223

Allgemeinen Krankenhaus Celle Kinderklinik, Celle

30559

Vinzenzkrankenhaus Hannover gGmbH, Hanover

31241

Frauenheilkunde u. Geburtshilfe, Ilsede

33076

Institut Bergonie, Bordeaux

33081

Centro di Riferimento Oncologico - Aviano, Aviano

39100

Azienda Sanitaria di Bolzano, Bolzano

39576

Johanniter Kankenhaus Stendal, Stendal

41009

Hospital Universitario Virgen Macarena, Seville

43201

Hospital Sant Joan de Reus, Reus

46009

Instituto Valenciano De Oncologia, Valencia

46010

Hospital Clinico Universitario de Valencia, Valencia

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

47900

Ospedale Civile Rimini, Rimini

59100

Misericordia e Dolce Hospital, Prato

72100

A. Perrino Hospital, Brindisi

73430

Aalen Breast Center, Aalen

87700

Klinikum Memmingen, Memmingen

90766

Praxis Dr. Wilke - Onkologie am Klinikum Fuerth, Fürth

94469

Klinikum Deggendorf, Deggendorf

98527

SRH Zentralklinikum Suhl GmbH, Suhl

98617

Klinikum Meiningen GmbH, Meiningen

115478

Russian Academy of Medical Sciences Cancer Research Center, Moscow

400012

Tata Memorial Hospital, Mumbai

02115

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute, Boston

02130-3400

Faulkner Hospital, Boston

A-6807

Landeskrankenhaus Feldkirch, Feldkirch

A-8036

Medizinische Universitaet Graz, Graz

A-6020

Innsbruck Universitaetsklinik, Innsbruck

A-4010

Krankenhaus BHS Linz, Linz

A-4021

Allgemeines Krankenhaus Linz, Linz

A-5020

St. Johanns-Spital, Salzburg

A-1090

Allgemeines Krankenhaus - Universitatskliniken, Vienna

A-1130

Krankenhaus Lainz, Vienna

A-1140

Hanusch-Krankenhaus, Vienna

B-2020

Ziekenhuis Netwerk Antwerpen Middelheim, Antwerp

B 1020

Centre Hospitalier Universitaire Brugmann, Brussels

B-9000

Universitair Ziekenhuis Gent, Ghent

B-3000

U.Z. Gasthuisberg, Leuven

B 4000

Clinique Saint-Joseph, Liège

B-4000

CHU Liege - Domaine Universitaire du Sart Tilman, Liège

B-2170

Jan Palfijn Hospital, Merksem

B-1340

Clinique Saint-Pierre, Ottignies

B-4800

Centre Hospitalier Peltzer-La Tourelle, Verviers

Unknown

Hospital Clinico San Borja Arriaran, Santiago

Instituto Nacional Del Cancer, Santiago

IRAM - Chile, Santiago

Hospital Clinico Regional de Valdivia at University Austral de Chile, Valdivia

Hospital Carlos Van Buren, Valparaíso

Sagara Hospital, Kagoshima

Malarsjukhuset Hospital, Eskilstuna

DK-8000

Aarhus Universitetshospital - Aarhus Sygehus, Aarhus C

DK-2730

Copenhagen County Herlev University Hospital, Copenhagen

DK-6700

Centralsygehus Esbjerg, Esbjerg

DK-7400

Herning Central Hospital, Herning

DK-5000

Odense University Hospital, Odense

DK-7100

Vejle Sygehus, Vejle

D-33602

Onkologische Schwerpunktpraxis Bielefeld, Bielefeld

D-30171

Henriettenstiftung Krankenhaus, Hanover

D-30177

Gynaekologisch-onkologische Praxis Hannover, Hanover

D-35423

Asklepios Klinik Lich, Lich

D68161

Gemeinschaftspraxis Gynaekologie & Geburtshilfe, Mannheim

D-63069

Klinikum Offenback GmbH, Offenbach

D-74523

Deaconess Hospital, Schwäbisch Hall

D-72076

Universitaetsklinikum Tuebingen, Tübingen

H-6720

Szeged University, Szeged

I-27100

Fondazione Salvatore Maugeri, Pavia

1179-3

Osaka Rosai Hospital, Sakai

860-8556

Kumamoto University Faculty of Medical and Pharmaceutical Sciences, Kumamoto

606-8507

Kyoto University Hospital, Kyoto

951-8566

Niigata Cancer Center Hospital, Niigata

581-0069

Yao Municipal Hospital, Osaka

113-8677

Tokyo Metropolitan - Komagome Hospital, Tokyo

08035

Vall d'Hebron University Hospital, Barcelona

07198

Hospital Son Llatzer, Palma de Mallorca

03180

Hospital de Torrevieja, Torrevieja

501 15

Lasarettet i Boras, Borås

S-413 45

Sahlgrenska University Hospital, Gothenburg

S-53185

Lidkoping Hospital, Lidköping

541 85

Skaraborgs Hospital, Skövde

S-141 86

Karolinska University Hospital - Huddinge, Stockholm

CH-5001

Kantonsspital Aarau, Aarau

CH-5404

Kantonsspital Baden, Baden

CH-6500

Istituto Oncologico della Svizzera Italiana - Ospedale San Giovanni, Bellinzona

CH-3010

Inselspital Bern, Bern

CH-3012

Oncocare Sonnenhof-Klinik Engeriedspital, Bern

CH-6330

AndreasKlinik Cham Zug, Cham

CH-7000

Kantonsspital Graubuenden, Chur

CH-1011

Centre Hospitalier Universitaire Vaudois, Lausanne

CH-6903

Ospedale Civico, Lugano

CH-6850

Ospedale Beata Vergine, Mendrisio

CH-4600

Kantonsspital Olten, Olten

CH-9006

Tumor Zentrum ZeTup St. Gallen und Chur, Sankt Gallen

CH-9007

Kantonsspital - St. Gallen, Sankt Gallen

CH -1951

Hopital Regional de Sion-Herens-Conthey, Sion

CH-8400

Kantonsspital Winterthur, Winterthur

CH-8008

Breast Center, Zurich

CH-8063

City Hospital Triemli, Zurich

CH-8091

UniversitaetsSpital Zuerich, Zurich

TD6 9BS

Borders General Hospital, Melrose

DG1 4AP

Dumfries & Galloway Royal Infirmary, Dumfries

Sponsors
All Listed Sponsors
collaborator

Breast International Group

OTHER

lead

ETOP IBCSG Partners Foundation

NETWORK

NCT00553410 - Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer | Biotech Hunter | Biotech Hunter