Proteomic Profiling in Predicting Response in Patients Receiving Erlotinib for Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

116

Participants

Timeline

Start Date

October 31, 2007

Primary Completion Date

September 30, 2011

Study Completion Date

December 31, 2013

Conditions
Lung Cancer
Interventions
DRUG

bevacizumab

15 mg/m2 given through a vein for every 3 weeks

DRUG

carboplatin

AUC = 6 given through a vein on day 1 of each cycle.

DRUG

erlotinib hydrochloride

150 mg taken by mouth daily

DRUG

paclitaxel

200 mg/m2 given through a vein on day 1 of each cycle.

GENETIC

gene expression analysis

Blood and tissue collection.

GENETIC

protein expression analysis

Blood and tissue collection.

GENETIC

proteomic profiling

Blood and tissue collection.

OTHER

laboratory biomarker analysis

Blood and tissue collection.

Trial Locations (7)

30308

Emory University, Atlanta

37064

Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville

Vanderbilt-Ingram Cancer Center at Franklin, Nashville

32610-0232

University of Florida Shands Cancer Center, Gainesville

48109-0942

University of Michigan Comprehensive Cancer Center, Ann Arbor

37232-6838

Vanderbilt-Ingram Cancer Center, Nashville

77030-4009

M. D. Anderson Cancer Center at University of Texas, Houston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Vanderbilt-Ingram Cancer Center

OTHER

NCT00550537 - Proteomic Profiling in Predicting Response in Patients Receiving Erlotinib for Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter