850
Participants
Start Date
October 31, 2005
Primary Completion Date
December 31, 2011
Study Completion Date
May 31, 2019
SoC therapy
the patients have to be treated according the standard good medical practice by any center
irbesartan
"Therapy for hypertension:~\- Step 1: irbesartan 300 mg/die and ramipril 10 mg/die"
ramipril
"Therapy for hypertension:~\- Step 1: irbesartan 300 mg/die and ramipril 10 mg/die"
hydrochlorothiazide
"Therapy for hypertension~\- Step 2: Diuretic (hydrochlorothiazide 12.5-25 mg/die if serum creatinine \<2 mg/dl, furosemide 25-75 mg/die if serum creatinin ≥2 mg/dl)"
furosemide
"Therapy for hypertension~\- Step 2: Diuretic (hydrochlorothiazide 12.5-25 mg/die if serum creatinine \<2 mg/dl, furosemide 25-75 mg/die if serum creatinin ≥2 mg/dl)"
amlodipine
"Therapy for hypertension~\- Step 3: amlodipine up to 10 mg/die"
atenolol
"Therapy for hypertension~\- Step 4: atenolol up to 100 mg/die"
doxazosin
"Therapy for hypertension~\- Step 5: doxazosin up to 4 mg/die"
clonidine
"Therapy for hypertension~\- Step 6: clonidine"
insulin
"Therapy for Hyperglycaemia (to achieve HbA1c \<7):~\- insulin"
simvastatin
"Therapy for hypercholesterolemia:~\- for reducing LDL cholesterol \< 100 mg/dl: simvastatin up to 80 mg/die"
fibrate
"Therapy for hypertriglyceridemia~\- for reducing triglycerides \< 150 mg/dl and/or increasing HDL cholesterol \> 40-50 mg/dl: a fibrate"
erythropoietin
"Treatment of anaemia:~\- erythropoietin"
aspirin
"Antiplatelet therapy (in all patients without contraindications):~\- aspirin up to 160 mg/die"
"Department of Advanced Medical and Surgical Sciences, Università della Campania Luigi Vanvitelli, Naples, Italy", Naples
University of Campania Luigi Vanvitelli
OTHER