A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid Arthritis

PHASE3CompletedINTERVENTIONAL
Enrollment

132

Participants

Timeline

Start Date

October 31, 2007

Primary Completion Date

September 30, 2008

Study Completion Date

January 31, 2011

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Tocilizumab

Administered by intravenous infusion, 8 mg/kg every 4 weeks.

DRUG

Placebo

Placebo to tocilizumab administered by intravenous infusion every 4 weeks.

DRUG

Methotrexate

Administered orally or parenterally, 7.5-25 mg weekly.

Trial Locations (40)

16635

Altoona Center For Clinical Research, Duncansville

18103

Lehigh Valley Hospital; Dept of Medicine, Allentown

19610

Clinical Research Center of Reading, Wyomissing

21224

Johns Hopkins Uni, Baltimore

28803

Asheville Arthritis & Osteoporosis Center, PA, Asheville

30342

Arthritis & Rheumatology of Georgia, Atlanta

33180

Arthritis & Rheumatism; Disease Specialities, Aventura

33458

Science and Research Institute, Inc., Jupiter

33614

Burnette & Silverfield, MDS, Tampa

34239

Sarasota Arthritis Center; Research Dept, Sarasota

34684

Arthritis Center Palm Harbor, Palm Harbor

Arthritis Rsrch of Florida, Inc., Palm Harbor

35801

Rheumatology Associates of North Alabama, Huntsville

36207

Pinnacle Research Group; Llc, Central, Anniston

39232

Jackson Arthritis Clinic, Flowood

49048

Borgess Research Institute, Kalamazoo

60061

Deerbrook Medical Associates, Vernon Hills

63131

Physicians Group, LC DBA Rheumatology & Internal Medicine Associates, St Louis

73103

Health Research of Oklahoma, Llc, Oklahoma City

77074

Houston Inst. For Clinical Research, Houston

77479

Texas Research Center, Sugar Land

85258

Advanced Arthritis Care & Research, Scottsdale

85704

Catalina Pointe Clinical Research, Inc., Tucson

90045

Pacific Arthritis Care Center, Los Angeles

98502

South Puget Sound Clinical Research, Olympia

07012

NJP Clinical Research, Clifton

T6G 2S2

The Governors of the Uni of Alberta; Heritage Medical Research Centre, Edmonton

V5Z 3Y1

Laurel Medical Clinic, Vancouver

R3A 1M3

Manitoba Clinic, Winnipeg

A1A 5E8

Nexus Clinical Research Centre, St. John's

L8N 1Y2

Dr. William G. Bensen Medicine Professional Corporation, Hamilton

L5M 2V8

Credit Valley, Rheumatology, Mississauga

K1H 1A2

Rheumatology Research Associates, Ottawa

M4K 1N2

Private Practice, Toronto

J1H 5N4

Chus Hopital Fleurimont, Sherbrooke

G1W 4R4

Centre Re Recherche Saint-Louis, Québec

00716

Ponce School of Medicine; Caimed Center, Ponce

G4 0SF

Glasgow Royal Infirmary; Centre For Rheumatic Diseases, Glasgow

M41 5SL

Trafford General Hospital; Rheumatology, Manchester

NE1 4LP

Royal Victoria Infirmary; Clinical Research Facility, Newcastle upon Tyne

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT00535782 - A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid Arthritis | Biotech Hunter | Biotech Hunter