Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock

PHASE3CompletedINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

October 31, 2007

Primary Completion Date

April 30, 2010

Study Completion Date

June 30, 2010

Conditions
Severe SepsisSeptic Shock
Interventions
DRUG

meropenem

Empirical antibiotic therapy with 3 x 1 g intravenous meropenem. Dosage is adjusted in case of renal dysfunction. Recommended duration of therapy is 7 days but can be extended up to 14 days.

DRUG

meropenem, moxifloxacin

Empirical antibiotic therapy with 3 x 1 g intravenous meropenem plus 1 x 400 mg intravenous moxifloxacin. Dosage of meropenem is adjusted in case of renal dysfunction. Recommended duration of therapy is 7 days but can be extended up to 14 days.

Trial Locations (52)

10117

Charité Berlin - Dep. of Anesthesiology and Intensive Care Medicine, Berlin

Charité Berlin - Dep. of Medicine (Cardiology, Angiology, Pneumology), Berlin

Charité Campus Mitte -Dep.of Infectiology and Pneumonology, Berlin

12203

Charité Campus Benjamin Franklin - Dep. of Medicine IV, Berlin

12313

Vivantes Klinikum Neukölln - Cardiology, Berlin

Vivantes Klinikum Neukölln - Dep. of Anesthesiology, Intensive Care Medicine and Pain Therapy, Berlin

13353

Charité Berlin - Campus Virchow-Klinikum - Dep. of Nephrology, Berlin

14467

Klinikum Ernst von Bergmann - Dep. of Anesthesiology and Intensive Care Medicine, Potsdam

14770

Städtisches Klinikum Brandenburg - Intensive Care Unit, Brandenburg

17475

Ernst-Moritz-Arndt-Universität Greifswald - Dep. of Anesthesiology and Intensive Care Medicine, Greifswald

Ernst-Moritz-Arndt-Universität Greifswald, Dep. of Internal Medicine B, Greifswald

18057

University Hospital Rostock - Dep. of Anesthesiology and Intensive Care Medicine, Rostock

20246

Universitätsklinikum Hamburg-Eppendorf - Dep. of Intensive Care Medicine, Hamburg

24105

University Hospital Kiel - Dep. of. Anesthesiology and Intensive Care Medicine, Kiel

25746

Westküstenklinikum Heide - Dep. of Anesthesiology and Intensive Care Medicine, Heide

26133

Klinikum Oldenburg - Dep. of Anesthesiology, Intensive Care Medicine, Emergency Medicine, Pain Therapy, Oldenburg

30167

Klinikum Hannover Nordstadt - Dep. of Anesthesiology and Intensive Care Medicine, Hanover

30625

Medizinische Hochschule Hannover, Dep. of Internal Medicine/ Pneumology, Hanover

32756

Hospital Lippe-Detmold - Dep. of Anesthesiology and Intensive Care Medicine, Detmold

33617

Ev. Krankenhaus Gilead I - Dep. of Anesthesiology and Intensive Care Medicine, Bielefeld

37075

Georg August Universität Göttingen - Dep. of Anesthesiology and Intensive Care Medicine, Göttingen

48149

University Hospital Münster - Dep. of Anesthesiology and Intensive Care Medicine, Münster

50924

University Hospital Köln - Dep. of Internal Medicine I, Cologne

51109

Hospital Merheim - Dep. of Anesthesiology and Intensive Care Medicine, Cologne

52074

University Hospital Aachen - Dep. of Anesthesiology, Aachen

53105

University Hospital Bonn - Dep. of Anesthesiology and Intensive Care Medicine, Bonn

57074

Ev. Jung-Stilling-Krankenhaus - Dep. of Anesthesiology, Intensive Care Medicine, Emergency Medicine, Siegen

58515

Klinikum Lüdenscheid - Dep. of Anesthesiology, Lüdenscheid

64283

Klinikum Darmstadt - Dep. of Anesthesiology, Intensive Care Medicine and Pain Therapy, Darmstadt

66421

University Hospital Saarland - Deop. of Anesthesiology, Intensive Care Medicine, and Pain Therapy, Homburg/Saar

67063

Hospital Ludwigshafen am Rhein - Dep. of Cardiac Surgery, Ludwigshafen

68167

University Hospital Mannheim - Dep. of Medicine I, Mannheim

69120

University Hospital Heidelberg - Dep. of Medicine IV, Heidelberg

University Hospital Heidelberg - Dep. of Visceral and Transplantation Surgery, Heidelberg

72076

University Hospital Tübingen - Dep. of Medicine, Tübingen

73035

Klinik am Eichert - Dep. of Anesthesiology, Intensive Care Medicine, and Pain Therapy, Göppingen

79106

University Hospital Freiburg - Dep. of Medicine III, Freiburg im Breisgau

80336

University Hospital Munich - Dep. of Internal Medicine, Munich

81545

Hospital Munich Harlaching - Dep. of Internal Acute Medicine and Prevention, Munich

81675

Klinikum rechts der Isar - Dep. of Anesthesiology, Munich

86156

Klinikum Augsburg - Dep. of Anesthesiology and Intensive Care Medicine, Augsburg

89081

University Hospital Ulm - Dep. of Internal Medicine II, Ulm

91054

University Erlangen-Nürnberg - Dep. of Medicine IV, Erlangen

97070

Stiftung Juliusspital Würzburg - Dep. of Medicine (Cardiology), Würzburg

99089

HELIOS Klinikum Erfurt - Dep. of Anesthesiology and Intensive Care Medicine, Erfurt

06847

Klinikum Dessau - Dep. of Medicine, Dessau

01067

Krankenhaus Dresden-Friedrichstadt, Dresden

01307

University Hospital Dresden - Dep. of Anesthesiology and Intensive Care Med., Dresden

06097

Martin-Luther-Universität Halle-Wittenberg - Dep. of Anesthesiology and Intensive Care Medicine, Halle

06120

Hospital Martha-Maria Halle-Dölau gGmbH - Dep. of Anesthesiology and Intensive Care Medicine, Halle

07747

University Hospital Jena, Dep. of Anesthesiology and Intensive Care Medicine, Jena

04103

University Hospital Leipzig - Dep. of Anesthesiology and Intensive Care Medicine, Leipzig

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Bayer

INDUSTRY

lead

Kompetenznetz Sepsis

NETWORK