544
Participants
Start Date
November 30, 2007
Primary Completion Date
June 30, 2013
Study Completion Date
May 20, 2022
Cetuximab
Loading dose: 400 mg/m2, IV, one week prior to start of radiation therapy (RT). Then, beginning day 1 of RT, 250 mg/m2, IV, weekly; for 60 Gy arm for 15 weeks, for 74 Gy arm for 16 weeks.
Carboplatin
"Concurrent: AUC=2, IV, days 1, 8, 14, 22, 29, and 36 of radiation therapy; for 74 Gy arms, on day 43 as well.~Consolidation, 3 weeks after completion of RT, AUC=6, IV, days 1 and 22."
Paclitaxel
"Concurrent: 45 mg/m2, IV, days 1, 8, 14, 22, 29, and 36 of radiation therapy (RT); for 74 Gy arms, on day 43 as well.~Consolidation, 3 weeks after completion of RT, 200 mg/m2, IV, days 1 and 22."
60 Gy RT
Radiation therapy (RT) in once-daily, 2 Gy fractions, given in 30 fractions over the course of 6 weeks.
74 Gy RT
Radiation therapy (RT) in once-daily, 2 Gy fractions, given in 37 fractions over the course of 7.5 weeks.
St. Luke's - Roosevelt Hospital Center - St.Luke's Division, New York
New York Oncology Hematology, PC at Albany Regional Cancer Care, Albany
Veterans Affairs Medical Center - Albany, Albany
SUNY Upstate Medical University Hospital, Syracuse
Sands Cancer Center, Canandaigua
Highland Hospital of Rochester, Rochester
University Radiation Oncology at Parkridge Hospital, Rochester
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Regional Cancer Center - Erie, Erie
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest, Allentown
Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg
Northeast Radiation Oncology Center, Dunmore
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre
Bryn Mawr Hospital, Bryn Mawr
Lankenau Cancer Center at Lankenau Hospital, Wynnewood
Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia
Albert Einstein Cancer Center, Philadelphia
CCOP - Christiana Care Health Services, Newark
Washington Cancer Institute at Washington Hospital Center, Washington D.C.
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
St. Agnes Hospital Cancer Center, Baltimore
Shore Regional Cancer Center at Memorial Hospital - Easton, Easton
Peninsula Regional Medical Center, Salisbury
University of Virginia Cancer Center, Charlottesville
Alamance Cancer Center at Alamance Regional Medical Center, Burlington
Cancer Centers of North Carolina - Raleigh, Raleigh
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center, Pinehurst
Kinston Medical Specialists, Kinston
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg
Hollings Cancer Center at Medical University of South Carolina, Charleston
Cancer Centers of the Carolinas - Faris Road, Greenville
CCOP - Greenville, Greenville
Cancer Centers of the Carolinas - Seneca, Seneca
Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur
Georgia Cancer Center for Excellence at Grady Memorial Hospital, Atlanta
Emory Crawford Long Hospital, Atlanta
Piedmont Hospital, Atlanta
Winship Cancer Institute of Emory University, Atlanta
Integrated Community Oncology Network - Orange Park, Orange Park
Flagler Cancer Center, Saint Augustine
Florida Cancer Center - Palatka, Palatka
Baptist Cancer Institute - Jacksonville, Jacksonville
Integrated Community Oncology Network at Southside Cancer Center, Jacksonville
Mayo Clinic - Jacksonville, Jacksonville
Integrated Community Oncology Network, Jacksonville Beach
Baptist Medical Center South, Jacksonville
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola
M.D. Anderson Cancer Center at Orlando, Orlando
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood
CCOP - Mount Sinai Medical Center, Miami Beach
Baptist-South Miami Regional Cancer Program, Miami
Broward General Medical Center Cancer Center, Fort Lauderdale
Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter
UAB Comprehensive Cancer Center, Birmingham
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport
University of Mississippi Cancer Clinic, Jackson
Regional Cancer Center at Singing River Hospital, Pascagoula
Flower Hospital Cancer Center, Sylvania
St. Charles Mercy Hospital, Oregon
St. Anne Mercy Hospital, Toledo
Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland
UHHS Chagrin Highlands Medical Center, Orange
Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights
Southwest General Health Center, Middleburg Heights
Cleveland Clinic Cancer Center, Independence
UHHS Westlake Medical Center, Westlake
Cleveland Clinic Taussig Cancer Center, Cleveland
Barberton Citizens Hospital, Barberton
McDowell Cancer Center at Akron General Medical Center, Akron
Cleveland Clinic - Wooster, Wooster
North Coast Cancer Care, Incorporated, Sandusky
Charles M. Barrett Cancer Center at University Hospital, Cincinnati
Adena Regional Medical Center, Chillicothe
Central Indiana Cancer Centers - East, Indianapolis
Community Regional Cancer Care at Community Hospital East, Indianapolis
Community Regional Cancer Care at Community Hospital North, Indianapolis
Center for Cancer Care at Goshen General Hospital, Goshen
Radiation Oncology Associates Southwest, Fort Wayne
Parkview Regional Cancer Center at Parkview Health, Fort Wayne
Mercy Regional Cancer Center at Mercy Hospital, Port Huron
St. Mary Mercy Hospital, Livonia
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines
Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines
Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City
Siouxland Hematology-Oncology Associates, LLP, Sioux City
Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids
D.N. Greenwald Center, Mukwonago
Waukesha Memorial Hospital Regional Cancer Center, Waukesha
Medical College of Wisconsin Cancer Center, Milwaukee
Veterans Affairs Medical Center - Milwaukee, Milwaukee
All Saints Cancer Center at Wheaton Franciscan Healthcare, Racine
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
Bellin Memorial Hospital, Green Bay
St. Mary's Hospital Medical Center - Green Bay, Green Bay
Riverview UW Cancer Center at Riverview Hospital, Wisconsin Rapids
Gundersen Lutheran Center for Cancer and Blood, La Crosse
Luther Midlelfort Hospital, Eau Claire
Theda Care Cancer Institute, Appleton
Regions Hospital Cancer Care Center, Saint Paul
Minnesota Oncology Hematology, PA - Maplewood, Maplewood
Fairview Ridges Hospital, Burnsville
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis
Mayo Clinic Cancer Center, Rochester
CentraCare Clinic - River Campus, Saint Cloud
CCOP - MeritCare Hospital, Fargo
Altru Cancer Center at Altru Hospital, Grand Forks
Trinity CancerCare Center, Minot
Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago
Cancer Treatment Center at Pekin Hospital, Pekin
Methodist Medical Center of Illinois, Peoria
OSF St. Francis Medical Center, Peoria
Community Cancer Center, Normal
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis
Barnes-Jewish West County Hospital, St Louis
Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters, City of Saint Peters
Methodist Estabrook Cancer Center, Omaha
Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center, Lincoln
MBCCOP - LSU Health Sciences Center, New Orleans
CCOP - Ochsner, New Orleans
Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge
Oklahoma University Cancer Institute, Oklahoma City
Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa
Texas Oncology, PA at Texas Cancer Center - Sherman, Sherman
Longview Cancer Center, Longview
Tyler Cancer Center, Tyler
Texas Oncology, PA at Texas Cancer Center - Arlington South, Arlington
Texas Oncology, PA at Harris Center HEB, Bedford
Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital, Fort Worth
Texas Oncology, PA at Texas Cancer Center - Denton South, Denton
Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land, Sugar Land
Cancer Care Centers of South Texas - Northeast, San Antonio
Harrington Cancer Center, Amarillo
West Texas Cancer Center, Odessa
Swedish Medical Center, Englewood
North Suburban Medical Center, Thornton
Poudre Valley Radiation Oncology, Fort Collins
Penrose Cancer Center at Penrose Hospital, Colorado Springs
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center, Boise
Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray
Utah Valley Regional Medical Center - Provo, Provo
Dixie Regional Medical Center - East Campus, St. George
Arizona Oncology - Tucson, Tucson
CCOP - Nevada Cancer Research Foundation, Las Vegas
Renown Institute for Cancer at Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
St. Joseph Hospital Regional Cancer Center - Orange, Orange
Saint Agnes Cancer Center at Saint Agnes Medical Center, Fresno
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Saint Helena Hospital, St. Helena
Memorial Medical Center, Modesto
Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael
Radiation Oncology Center - Roseville, Roseville
Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento
University of California Davis Cancer Center, Sacramento
Enloe Cancer Center at Enloe Medical Center, Chico
Feather River Hospital Cancer Center, Paradise
Willamette Valley Cancer Center - Eugene, Eugene
CCOP - Virginia Mason Research Center, Seattle
Cancer Care Northwest - Spokane South, Spokane
Mayo Clinic Scottsdale, Scottsdale
Cancer Care Center at John Muir Health - Concord Campus, Concord
Rebecca and John Moores UCSD Cancer Center, La Jolla
Stanford Cancer Center, Stanford
University of Florida Shands Cancer Center, Gainesville
University of Chicago Cancer Research Center, Chicago
Cancer Center at Ball Memorial Hospital, Muncie
Central Baptist Hospital, Lexington
Tulane Cancer Center Office of Clinical Research, Alexandria
Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield
Saint Joseph Mercy Cancer Center, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
West Michigan Cancer Center, Kalamazoo
Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale
Billings Clinic - Downtown, Billings
Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney
Payson Center for Cancer Care at Concord Hospital, Concord
Center for Cancer Care at Exeter Hospital, Exeter
Elliot Regional Cancer Center at Elliot Hospital, Manchester
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton
UMDNJ University Hospital, Newark
J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River
Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township
University of New Mexico Cancer Center, Albuquerque
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Summa Center for Cancer Care at Akron City Hospital, Akron
Aultman Cancer Center at Aultman Hospital, Canton
Case Comprehensive Cancer Center, Cleveland
Riverside Methodist Hospital Cancer Care, Columbus
Geisinger Cancer Institute at Geisinger Health, Danville
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center, Hershey
Cancer Center of Paoli Memorial Hospital, Paoli
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia
Fox Chase Cancer Center - Philadelphia, Philadelphia
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center, Reading
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls
M. D. Anderson Cancer Center at University of Texas, Houston
Fletcher Allen Health Care - University Health Center Campus, Burlington
Midelfort Clinic - Luther, Eau Claire
St. Vincent Hospital Regional Cancer Center, Green Bay
Door County Cancer Center at Door County Memorial Hospital, Sturgeon Bay
Tom Baker Cancer Centre - Calgary, Calgary
CancerCare Manitoba, Winnipeg
Princess Margaret Hospital, Toronto
Hopital Notre-Dame du CHUM, Montreal
Allan Blair Cancer Centre at Pasqua Hospital, Regina
Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon
Collaborators (1)
National Cancer Institute (NCI)
NIH
North Central Cancer Treatment Group
NETWORK
Cancer and Leukemia Group B
NETWORK
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK