High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

PHASE3CompletedINTERVENTIONAL
Enrollment

544

Participants

Timeline

Start Date

November 30, 2007

Primary Completion Date

June 30, 2013

Study Completion Date

May 20, 2022

Conditions
Lung CancerRadiation Toxicity
Interventions
BIOLOGICAL

Cetuximab

Loading dose: 400 mg/m2, IV, one week prior to start of radiation therapy (RT). Then, beginning day 1 of RT, 250 mg/m2, IV, weekly; for 60 Gy arm for 15 weeks, for 74 Gy arm for 16 weeks.

DRUG

Carboplatin

"Concurrent: AUC=2, IV, days 1, 8, 14, 22, 29, and 36 of radiation therapy; for 74 Gy arms, on day 43 as well.~Consolidation, 3 weeks after completion of RT, AUC=6, IV, days 1 and 22."

DRUG

Paclitaxel

"Concurrent: 45 mg/m2, IV, days 1, 8, 14, 22, 29, and 36 of radiation therapy (RT); for 74 Gy arms, on day 43 as well.~Consolidation, 3 weeks after completion of RT, 200 mg/m2, IV, days 1 and 22."

RADIATION

60 Gy RT

Radiation therapy (RT) in once-daily, 2 Gy fractions, given in 30 fractions over the course of 6 weeks.

RADIATION

74 Gy RT

Radiation therapy (RT) in once-daily, 2 Gy fractions, given in 37 fractions over the course of 7.5 weeks.

Trial Locations (213)

10025

St. Luke's - Roosevelt Hospital Center - St.Luke's Division, New York

12206

New York Oncology Hematology, PC at Albany Regional Cancer Care, Albany

12208

Veterans Affairs Medical Center - Albany, Albany

13210

SUNY Upstate Medical University Hospital, Syracuse

14424

Sands Cancer Center, Canandaigua

14620

Highland Hospital of Rochester, Rochester

14626

University Radiation Oncology at Parkridge Hospital, Rochester

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

16505

Regional Cancer Center - Erie, Erie

18105

Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest, Allentown

18301

Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg

18512

Northeast Radiation Oncology Center, Dunmore

18711

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Cancer Center at Lankenau Hospital, Wynnewood

19114

Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia

19141

Albert Einstein Cancer Center, Philadelphia

19713

CCOP - Christiana Care Health Services, Newark

20010

Washington Cancer Institute at Washington Hospital Center, Washington D.C.

21201

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore

21229

St. Agnes Hospital Cancer Center, Baltimore

21601

Shore Regional Cancer Center at Memorial Hospital - Easton, Easton

21801

Peninsula Regional Medical Center, Salisbury

22908

University of Virginia Cancer Center, Charlottesville

27216

Alamance Cancer Center at Alamance Regional Medical Center, Burlington

27607

Cancer Centers of North Carolina - Raleigh, Raleigh

28374

FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center, Pinehurst

28501

Kinston Medical Specialists, Kinston

29303

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

29605

Cancer Centers of the Carolinas - Faris Road, Greenville

29615

CCOP - Greenville, Greenville

29672

Cancer Centers of the Carolinas - Seneca, Seneca

30033

Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur

30303

Georgia Cancer Center for Excellence at Grady Memorial Hospital, Atlanta

30308

Emory Crawford Long Hospital, Atlanta

30309

Piedmont Hospital, Atlanta

30322

Winship Cancer Institute of Emory University, Atlanta

32073

Integrated Community Oncology Network - Orange Park, Orange Park

32086

Flagler Cancer Center, Saint Augustine

32177

Florida Cancer Center - Palatka, Palatka

32207

Baptist Cancer Institute - Jacksonville, Jacksonville

Integrated Community Oncology Network at Southside Cancer Center, Jacksonville

32224

Mayo Clinic - Jacksonville, Jacksonville

32250

Integrated Community Oncology Network, Jacksonville Beach

32258

Baptist Medical Center South, Jacksonville

32504

Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola

32806

M.D. Anderson Cancer Center at Orlando, Orlando

33021

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

33140

CCOP - Mount Sinai Medical Center, Miami Beach

33176

Baptist-South Miami Regional Cancer Program, Miami

33316

Broward General Medical Center Cancer Center, Fort Lauderdale

33458

Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter

35294

UAB Comprehensive Cancer Center, Birmingham

37662

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport

39216

University of Mississippi Cancer Clinic, Jackson

39581

Regional Cancer Center at Singing River Hospital, Pascagoula

43560

Flower Hospital Cancer Center, Sylvania

43616

St. Charles Mercy Hospital, Oregon

43623

St. Anne Mercy Hospital, Toledo

44111

Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland

44122

UHHS Chagrin Highlands Medical Center, Orange

44124

Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights

44130

Southwest General Health Center, Middleburg Heights

44131

Cleveland Clinic Cancer Center, Independence

44145

UHHS Westlake Medical Center, Westlake

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

44203

Barberton Citizens Hospital, Barberton

44307

McDowell Cancer Center at Akron General Medical Center, Akron

44691

Cleveland Clinic - Wooster, Wooster

44870

North Coast Cancer Care, Incorporated, Sandusky

45267

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

45601

Adena Regional Medical Center, Chillicothe

46219

Central Indiana Cancer Centers - East, Indianapolis

Community Regional Cancer Care at Community Hospital East, Indianapolis

46256

Community Regional Cancer Care at Community Hospital North, Indianapolis

46526

Center for Cancer Care at Goshen General Hospital, Goshen

46804

Radiation Oncology Associates Southwest, Fort Wayne

46805

Parkview Regional Cancer Center at Parkview Health, Fort Wayne

48060

Mercy Regional Cancer Center at Mercy Hospital, Port Huron

48154

St. Mary Mercy Hospital, Livonia

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

49503

Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids

50309

John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines

50314

Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines

50401

Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City

51101

Siouxland Hematology-Oncology Associates, LLP, Sioux City

52403

Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids

53149

D.N. Greenwald Center, Mukwonago

53188

Waukesha Memorial Hospital Regional Cancer Center, Waukesha

53226

Medical College of Wisconsin Cancer Center, Milwaukee

53295

Veterans Affairs Medical Center - Milwaukee, Milwaukee

53405

All Saints Cancer Center at Wheaton Franciscan Healthcare, Racine

54143

Bay Area Cancer Care Center at Bay Area Medical Center, Marinette

54301

Bellin Memorial Hospital, Green Bay

54303

St. Mary's Hospital Medical Center - Green Bay, Green Bay

54494

Riverview UW Cancer Center at Riverview Hospital, Wisconsin Rapids

54601

Gundersen Lutheran Center for Cancer and Blood, La Crosse

54703

Luther Midlelfort Hospital, Eau Claire

54911

Theda Care Cancer Institute, Appleton

55101

Regions Hospital Cancer Care Center, Saint Paul

55109

Minnesota Oncology Hematology, PA - Maplewood, Maplewood

55337

Fairview Ridges Hospital, Burnsville

55407

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis

55905

Mayo Clinic Cancer Center, Rochester

56303

CentraCare Clinic - River Campus, Saint Cloud

58122

CCOP - MeritCare Hospital, Fargo

58201

Altru Cancer Center at Altru Hospital, Grand Forks

58701

Trinity CancerCare Center, Minot

60657

Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago

61554

Cancer Treatment Center at Pekin Hospital, Pekin

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF St. Francis Medical Center, Peoria

61761

Community Cancer Center, Normal

63110

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis

63141

Barnes-Jewish West County Hospital, St Louis

63376

Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters, City of Saint Peters

68114

Methodist Estabrook Cancer Center, Omaha

68510

Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center, Lincoln

70112

MBCCOP - LSU Health Sciences Center, New Orleans

70121

CCOP - Ochsner, New Orleans

70809

Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge

73104

Oklahoma University Cancer Institute, Oklahoma City

74136

Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa

75090

Texas Oncology, PA at Texas Cancer Center - Sherman, Sherman

75601

Longview Cancer Center, Longview

75702

Tyler Cancer Center, Tyler

76014

Texas Oncology, PA at Texas Cancer Center - Arlington South, Arlington

76022

Texas Oncology, PA at Harris Center HEB, Bedford

76104

Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital, Fort Worth

76210

Texas Oncology, PA at Texas Cancer Center - Denton South, Denton

77479

Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land, Sugar Land

78217

Cancer Care Centers of South Texas - Northeast, San Antonio

79106

Harrington Cancer Center, Amarillo

79761

West Texas Cancer Center, Odessa

80110

Swedish Medical Center, Englewood

80229

North Suburban Medical Center, Thornton

80528

Poudre Valley Radiation Oncology, Fort Collins

80933

Penrose Cancer Center at Penrose Hospital, Colorado Springs

83706

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center, Boise

83712

Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise

84106

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City

84157

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray

84604

Utah Valley Regional Medical Center - Provo, Provo

84770

Dixie Regional Medical Center - East Campus, St. George

85704

Arizona Oncology - Tucson, Tucson

89106

CCOP - Nevada Cancer Research Foundation, Las Vegas

89502

Renown Institute for Cancer at Renown Regional Medical Center, Reno

89503

Saint Mary's Regional Medical Center, Reno

92868

St. Joseph Hospital Regional Cancer Center - Orange, Orange

93720

Saint Agnes Cancer Center at Saint Agnes Medical Center, Fresno

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94574

Saint Helena Hospital, St. Helena

95355

Memorial Medical Center, Modesto

95608

Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael

95661

Radiation Oncology Center - Roseville, Roseville

95815

Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento

95817

University of California Davis Cancer Center, Sacramento

95926

Enloe Cancer Center at Enloe Medical Center, Chico

95969

Feather River Hospital Cancer Center, Paradise

97401

Willamette Valley Cancer Center - Eugene, Eugene

98101

CCOP - Virginia Mason Research Center, Seattle

99202

Cancer Care Northwest - Spokane South, Spokane

85259-5499

Mayo Clinic Scottsdale, Scottsdale

94524-4110

Cancer Care Center at John Muir Health - Concord Campus, Concord

92093-0658

Rebecca and John Moores UCSD Cancer Center, La Jolla

94305-5824

Stanford Cancer Center, Stanford

32610-0232

University of Florida Shands Cancer Center, Gainesville

60637-1470

University of Chicago Cancer Research Center, Chicago

47303-3499

Cancer Center at Ball Memorial Hospital, Muncie

40503-9985

Central Baptist Hospital, Lexington

71315-3198

Tulane Cancer Center Office of Clinical Research, Alexandria

01107

Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield

48106-0995

Saint Joseph Mercy Cancer Center, Ann Arbor

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

49007-3731

West Michigan Cancer Center, Kalamazoo

55422-2900

Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale

59107-7000

Billings Clinic - Downtown, Billings

68848-1990

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney

03301

Payson Center for Cancer Care at Concord Hospital, Concord

03833

Center for Cancer Care at Exeter Hospital, Exeter

03103

Elliot Regional Cancer Center at Elliot Hospital, Manchester

08053

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton

07103

UMDNJ University Hospital, Newark

08755

J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River

08043

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township

87131-5636

University of New Mexico Cancer Center, Albuquerque

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

28233-3549

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte

44309-2090

Summa Center for Cancer Care at Akron City Hospital, Akron

44710-1799

Aultman Cancer Center at Aultman Hospital, Canton

44106-5065

Case Comprehensive Cancer Center, Cleveland

43214-3998

Riverside Methodist Hospital Cancer Care, Columbus

17822-0001

Geisinger Cancer Institute at Geisinger Health, Danville

17033-0850

Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center, Hershey

19301-1792

Cancer Center of Paoli Memorial Hospital, Paoli

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

19111-2497

Fox Chase Cancer Center - Philadelphia, Philadelphia

19612-6052

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center, Reading

57117-5039

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls

77030-4009

M. D. Anderson Cancer Center at University of Texas, Houston

05401

Fletcher Allen Health Care - University Health Center Campus, Burlington

54703-1510

Midelfort Clinic - Luther, Eau Claire

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

54235-1495

Door County Cancer Center at Door County Memorial Hospital, Sturgeon Bay

T2N 4N2

Tom Baker Cancer Centre - Calgary, Calgary

R3E 0V9

CancerCare Manitoba, Winnipeg

M5G 2M9

Princess Margaret Hospital, Toronto

H2L 4M1

Hopital Notre-Dame du CHUM, Montreal

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

S7N 4H4

Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

North Central Cancer Treatment Group

NETWORK

collaborator

Cancer and Leukemia Group B

NETWORK

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK