619
Participants
Start Date
October 31, 2007
Primary Completion Date
June 30, 2009
Study Completion Date
March 31, 2011
Tocilizumab
Tocilizumab intravenously at a dose of 8 mg/kg over a 1-hour infusion, every 4 weeks, for a total of 6 infusions.
Placebo
Placebo IV over a 1-hour infusion, every 4 weeks, for a total of 6 infusions.
Permitted DMARDs
As prescribed. The following DMARDs were permitted in this study: methotrexate (MTX), chloroquine, hydroxychloroquine, parenteral gold, sulfasalazine, azathioprine, and leflunomide. These DMARDs could be used alone or in combination, except for the combination of MTX and leflunomide, which was not allowed.
New York
New York
The Bronx
Bethlehem
Mineola
Smithtown
Orchard Park
Wexford
Pittsburgh
Philadelphia
Philadelphia
Washington D.C.
Wheaton
Burke
Reston
Salem
Beckley
Clarksburg
Greensboro
Durham
Greenville
Belmont
Charlotte
Charlotte
Hickory
Columbia
Charleston
Florence
Myrtle Beach
Greenville
Rock Hill
Atlanta
Blue Ridge
Fort Valley
Orange Park
Lake Mary
Orlando
Melbourne
Miami
Plantation
Tamarac
Fort Lauderdale
Tampa
Sarasota
Ocala
Palm Harbor
Dunedin
Birmingham
Birmingham
Montgomery
Hendersonville
Nashville
Knoxville
Memphis
Jackson
Crossville
Tupelo
Flowood
Lexington
Bowling Green
Perrysburg
Zanesville
Beechwood
Middleburg Heights
Mayfield
Akron
Munster
South Bend
Evansville
Saint Clair Shores
Kalamazoo
Milwaukee
Wausau
Onalaska
Eagan
Sioux Falls
Watertown
Rapid City
Rapid City
Billings
Missoula
Kalispell
Downers Grove
Springfield
Florissant
St Louis
Leawood
Grand Island
New Orleans
Baton Rouge
Baton Rouge
Monroe
Jonesboro
Norman
Oklahoma City
Oklahoma City
Carrollton
Mesquite
Dallas
Fort Worth
Temple
Waco
Houston
Houston
Houston
Houston
Bellaire
San Antonio
San Antonio
San Antonio
Amarillo
Amarillo
Willow Grove
Colorado Springs
Idaho Falls
Nampa
Boise
Salt Lake City
Scottsdale
Paradise Valley
Scottsdale
Peoria
Lake Havasu City
Las Vegas
Las Vegas
Reno
Los Angeles
Beverly Hills
Santa Monica
Whittier
Long Beach
Pasadena
Van Nuys
Upland
Escondido
La Jolla
Santa Maria
Walnut Creek
Lake Oswego
Portland
Salem
Seattle
Seattle
Tifton
Birmingham
Trumbull
Mansfield
Worcester
Worcester
Dover
Freehold
New Brunswick
Passaic
Teaneck
Burlington
Spokane
San Juan
Hoffmann-La Roche
INDUSTRY