Investigating the Biological Effects of the Addition of Zoledronic Acid to Pre-operative Chemotherapy in Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 31, 2007

Primary Completion Date

January 31, 2010

Study Completion Date

January 31, 2010

Conditions
Breast Cancer
Interventions
DRUG

5-FU, Epirubicin, Cyclophosphamide, Docetaxel

3 cycles of FEC q3w, followed by 3 cycles of docetaxel q3w FEC: 5FU 500mg/m2 intravenous bolus D1, Epirubicin 100mg/m2 intravenous bolus D1, Cyclophosphamide 500mg/m2 intravenous bolus D1) every 21 days Docetaxel: (100mg/ m2 intravenous infusion) every 21 days

DRUG

5-FU, Epirubicin, Cyclophosphamide, Docetaxel, Zoledronic acid

3 cycles of FEC q3w, followed by 3 cycles of docetaxel q3w FEC: 5FU 500mg/m2 intravenous bolus D1, Epirubicin 100mg/m2 intravenous bolus D1, Cyclophosphamide 500mg/m2 intravenous bolus D1) every 21 days Docetaxel: (100mg/ m2 intravenous infusion) every 21 days Zoledronic acid: 4mg intravenous infusion Day 2, AFTER FIRST CYCLE CHEMOTHERAPY ONLY

Trial Locations (1)

S10 2SJ

Sheffield Teaching Hospitals NHS Foundation Trust / Weston Park Hospital, Sheffield

All Listed Sponsors
collaborator

University of Sheffield

OTHER

lead

Sheffield Teaching Hospitals NHS Foundation Trust

OTHER

NCT00525759 - Investigating the Biological Effects of the Addition of Zoledronic Acid to Pre-operative Chemotherapy in Breast Cancer | Biotech Hunter | Biotech Hunter