Screening for Lung Cancer in Current or Past Smokers With Chronic Obstructive Pulmonary Disease

Samples tested and further interventions added if positive

Patients not diagnosed with lung cancer during the course of the study, will be offered an exit chest x-ray after 5 years or sooner if they withdraw from the trial before 5 years. This could help identify a lung cancer that may not have been associated with symptoms earlier.

The bronchial tree will be inspected first under white light and then under blue light. All areas that appear abnormal will initially be documented and only sampled when the bronchoscopic examination has been completed.

All patients with abnormal sputum cytology and/or cytometry will undergo low dose spiral CT without contrast.