Phase 2 Study of AMG 386 Plus Paclitaxel With or Without Bevacizumab as First Line Therapy in Her2-Negative Breast Cancer Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

228

Participants

Timeline

Start Date

July 31, 2007

Primary Completion Date

August 31, 2010

Study Completion Date

May 31, 2014

Conditions
Locally Recurrent and Metastatic Breast Cancer
Interventions
DRUG

AMG 386 Placebo

AMG 386 Placebo \[blinded\]

DRUG

AMG 386

AMG 386 3mg/kg IV QW \[blinded\]

DRUG

Bevacizumab

Bevacizumab 10mg/kg IV Q2W

DRUG

AMG 386

AMG 386 10mg/kg IV QW \[Open-Label\]

DRUG

AMG 386

AMG 386 10mg/kg IV QW \[blinded\]

DRUG

Paclitaxel

Paclitaxel 90mg/m2 IV QW (3 on/1 0ff)

Trial Locations (77)

1090

Research Site, Vienna

2610

Research Site, Wilrijk

2730

Research Site, Herlev

3000

Research Site, Leuven

3011

Research Site, Footscray

3065

Research Site, Fitzroy

3076

Research Site, Epping

3144

Research Site, Malvern

4000

Research Site, Liège

4600

Research Site, Wels

5037

Research Site, Kurralta Park

5700

Research Site, Gyula

6000

Research Site, Perth

6020

Research Site, Innsbruck

7400

Research Site, Kaposvár

8200

Research Site, Veszprém

9700

Research Site, Szombathely

13009

Research Site, Marseille

15706

Research Site, Santiago de Compostela

17033

Research Site, Hershey

19106

Research Site, Philadelphia

23007

Research Site, Jaén

28033

Research Site, Madrid

28203

Research Site, Charlotte

28806

Research Site, Asheville

29210

Research Site, Columbia

31052

Research Site, Toulouse

32804

Research Site, Orlando

34298

Research Site, Montpellier

54511

Research Site, Vandœuvre-lès-Nancy

55422

Research Site, Robbinsdale

69008

Research Site, Lyon

71913

Research Site, Hot Springs

72205

Research Site, Little Rock

75020

Research Site, Paris

75080

Research Site, Richardson

75248

Research Site, Paris

77479

Research Site, Sugar Land

78229

Research Site, San Antonio

84403

Research Site, Ogden

85340

Research Site, Litchfield Park

85724

Research Site, Tucson

85925

Research Site, La Roche-sur-Yon

89052

Research Site, Henderson

90095

Research Site, Los Angeles

92562

Research Site, Murrieta

93454

Research Site, Santa Maria

95008

Research Site, Campbell

06520

Research Site, New Haven

06902

Research Site, Stamford

03756

Research Site, Lebanon

03061

Research Site, Nashua

08820

Research Site, Edison

07046

Research Site, Mountain Lakes

00029

Research Site, Helsinki

560 029

Research Site, Bangalore

416 410

Research Site, Miraj

400 012

Research Site, Mumbai

440 012

Research Site, Nagpur

411 001

Research Site, Pune

302 004

Research Site, Jaipur

302 013

Research Site, Jaipur

6229 HX

Research Site, Maastricht

80-952

Research Site, Gdansk

59-300

Research Site, Lubin

61-485

Research Site, Poznan

02-781

Research Site, Warsaw

04-141

Research Site, Warsaw

53-413

Research Site, Wroclaw

08208

Research Site, Sabadell

GU2 7XX

Research Site, Guildford

LE1 5WW

Research Site, Leicester

NW1 2PG

Research Site, London

W6 8RF

Research Site, London

M20 4BX

Research Site, Manchester

HA6 2RN

Research Site, Northwood

NG5 1PB

Research Site, Nottingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY