Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA

2 x 500mg EPA capsules twice daily for 6 months

Endoscopy with video and photographs at baseline and month 6.

9 biopsies taken at baseline and month 6 from the rectum of normal mucosa for analysis of apoptosis (3 biopsies), cell proliferation (3 biopsies) and mucosal fatty acid levels (3 biopsies). Two biopsies taken at baseline and month 6 from polyps for cell proliferation (1 biopsy) and apoptosis (1 biopsy).

2 x 500mg placebo capsules twice daily for 6 months