Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,217

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

September 30, 2010

Study Completion Date

July 31, 2011

Conditions
Macular Degeneration
Interventions
BIOLOGICAL

ranibizumab

Participants received a 0.5mg dose of ranibizumab via intravitreal (IVT) injection every 4 weeks for the first year. Thereafter a dose may be administered as frequently as every 4 weeks, but no less frequently than every 12 weeks.

BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received a 2.0mg dose of aflibercept injection every 4 weeks for the first year. Thereafter a dose may be administered as frequently as every 4 weeks, but no less frequently than every 12 weeks.

BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received a 0.5mg dose of aflibercept injection every 4 weeks for the first year. Thereafter a dose may be administered as frequently as every 4 weeks, but no less frequently than every 12 weeks.

BIOLOGICAL

aflibercept injection (VEGF Trap-Eye, BAY86-5321)

Participants received a 2.0mg dose of aflibercept injection every 8 weeks (including one additional 2.0 mg dose at Week 4) for the first year and were to receive sham injections at interim monthly visits. Thereafter a dose may be administered as frequently as every 4 weeks, but no less frequently than every 12 weeks.

Trial Locations (188)

10003

New York

10021

New York

10032

New York

11223

Brooklyn

11563

Lynbrook

12159

Slingerlands

12206

Albany

12601

Poughkeepsie

13224

Syracuse

14620

Rochester

14642

Rochester

15122

West Mifflin

15212

Pittsburgh

15213

Pittsburgh

15231

Pittsberg

18704

Kingston

19104

Philadelphia

19107

Philadelphia

19124

Philadelphia

19610

Wyomissing

20815

Chevy Chase

21204

Towson

21209

Baltimore

21287

Baltimore

21740

Hagerstown

22031

Fairfax

22908

Charlottesville

23221

Richmond

27157

Winston-Salem

27607

Raleigh

28210

Charlotte

28387

Southern Pines

28803

Asheville

29169

West Columbia

29223

Columbia

29414

Charleston

29605

Greenville

30909

Augusta

32224

Jacksonville

32503

Pensacola

32610

Gainesville

32701

Altamonte Springs

32757

Mt. Dora

32803

Orlando

32806

Orlando

33136

Miami

33143

Miami

33351

Fort Lauderdale

33410

Palm Beach Gardens

33426

Boynton Beach

33612

Tampa

33880

Winter Haven

33907

Fort Myers

33912

Fort Myers

34472

Oscala

34994

Stuart

35205

Birmingham

35223

Birmingham

37203

Nashville

38119

Memphis

38120

Memphis

40202

Louisville

40207

Louisville

42001

Paducah

43215

Columbus

43608

Toledo

45202

Cincinnati

45242

Cincinnati

46202

Indianapolis

46260

Indianapolis

46280

Indianapolis

46804

Fort Wayne

47150

New Albany

48034

Southfield

48073

Royal Oak

48105

Ann Arbor

48202

Detroit

48322

West Bloomfield

49015

Battle Creek

49201

Jackson

49525

Grand Rapids

53226

Milwaukee

53715

Madison

55404

Minneapolis

55435

Edina

55905

Rochester

57701

Rapid City

58705

Madison

59801

Missoula

60523

Oak Brook

63031

Florissant

63110

St Louis

64108

Kansas City

64111

Kansas City

65804

Springfield

67214

Wichita

68131

Omaha

68506

Lincoln

70115

New Orleans

70121

New Orleans

71105

Shreveport

73104

Oklahoma City

75115

DeSoto

75390

Dallas

76102

Fort Worth

76104

Fort Worth

77030

Houston

77555

Galveston

78240

San Antonio

78413

Corpus Cristi

78503

McAllen

78705

Austin

79606

Abilene

79761

Odessa

80045

Aurora

80205

Denver

80230

Denver

84107

Salt Lake City

84132

Salt Lake City

85014

Phoenix

85020

Phoenix

85704

Tucson

85710

Tucson

87106

Albuquerque

89144

Las Vegas

90033

Los Angeles

90048

Los Angeles

90211

Beverly Hills

90503

Torrance

91105

Pasadena

91203

Glendale

91361

Westlake Village

92037

La Jolla

92064

Poway

92120

San Diego

92262

Palm Springs

92354

Loma Linda

92697

Irvine

92705

Santa Ana

92835

Fullerton

92887

Yorba Linda

93003

Ventura

94025

Menlo Park

94040

Mountain View

94107

San Francisco

94609

Oakland

95008

Campbell

95819

Sacramento

96701

‘Aiea

96813

Honolulu

97210

Portland

97227

Portland

97302

Salem

97520

Ashland

98104

Seattle

98383

Silverdale

06606

Bridgeport

06518

Hamden

06510

New Haven

06320

New London

Unknown

Sarasota

Boston

52242-1091

Iowa City

04401

Bangor

04102

Portland

02111

Boston

02114

Boston

02215

Boston

01960

Peabody

08648

Lawrenceville

08901

New Brunswick

08225

Northfield

07666

Teaneck

08753

Toms River

02903-4928

Providence

05401

Burlington

T3E 7MB

Calgary

V5Z 3N9

Vancouver

V8V 1B3

Victoria

B3H 2Y9

Halifax

N6A 4G5

London

L4W 1W9

Mississauga

K1H8L6

Ottawa

M4N3M5

Toronto

M5C 2T2

Toronto

H1T 2M4

Montreal

H3A 1A1

Montreal

S4T 1A5

Regina

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

Regeneron Pharmaceuticals

INDUSTRY