Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

July 11, 2007

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2026

Conditions
T Acute Lymphoblastic LeukemiaT Lymphoblastic Lymphoma
Interventions
DRUG

Cyclophosphamide

Given IV

DRUG

Cytarabine

Given IV

DRUG

Dexamethasone

Given IV or PO

DRUG

Doxorubicin Hydrochloride

Given IV

DRUG

Mercaptopurine

Given PO

DRUG

Methotrexate

Given IV and PO

DRUG

Nelarabine

Given IV

DRUG

Pegaspargase

Given IV

DRUG

Prednisone

Given PO

DRUG

Venetoclax

Given PO

DRUG

Vincristine Sulfate

Given IV

Trial Locations (1)

77030

RECRUITING

M D Anderson Cancer Center, Houston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

M.D. Anderson Cancer Center

OTHER