464
Participants
Start Date
October 8, 2007
Primary Completion Date
June 30, 2014
Study Completion Date
June 30, 2021
carboplatin
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
etoposide
Given orally
topotecan hydrochloride
Given IV
Isotretinoin
Given orally
Surgery
With the exception of patients with INSS 4S disease, patients undergo surgery to remove as much of the primary tumor and involved lymph nodes as can safely be accomplished.
Filgrastim
Administered subcutaneously or by IV beginning 24-48 hrs after the last dose of chemotherapy \& continuing daily until the ANC is greater than or equal to 1500 following the myelosuppressive nadir . Supportive care given to stimulate neutrophil recovery following chemotherapy and to shorten the duration of chemotherapy-induced neutropenia. On ANBL0531 the use of filgrastim was required for patients less than 60 days of age and was optional for other patients.
Starship Children's Health, Auckland
Children's Hospital at Westmead, Westmead
Royal Children's Hospital, Brisbane
Women's and Children's Hospital, North Adelaide
Princess Margaret Hospital for Children, Perth
Universitair Medisch Centrum St. Radboud - Nijmegen, Nijmegen
Christchurch Hospital, Christchurch
NYU Cancer Institute at New York University Medical Center, New York
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx
New York Medical College, Valhalla
Schneider Children's Hospital, New Hyde Park
Maimonides Cancer Center at Maimonides Medical Center, Brooklyn
Winthrop University Hospital, Mineola
SUNY Upstate Medical University Hospital, Syracuse
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Alfred I. duPont Hospital for Children, Wilmington
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington D.C.
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore
University of Virginia Cancer Center, Charlottesville
Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke
West Virginia University Health Sciences Center - Charleston, Charleston
Duke Comprehensive Cancer Center, Durham
Mission Hospitals - Memorial Campus, Asheville
Palmetto Health South Carolina Cancer Center, Columbia
Hollings Cancer Center at Medical University of South Carolina, Charleston
Greenville Hospital Cancer Center, Greenville
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus, Atlanta
Nemours Children's Clinic, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
M.D. Anderson Cancer Center at Orlando, Orlando
Nemours Children's Clinic - Orlando, Orlando
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood
University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami
Baptist-South Miami Regional Cancer Program, Miami
Broward General Medical Center Cancer Center, Fort Lauderdale
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach
St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa
All Children's Hospital, St. Petersburg
Lee Cancer Care of Lee Memorial Health System, Fort Myers
UAB Comprehensive Cancer Center, Birmingham
University of South Alabama Mitchell Cancer Institute, Mobile
T.C. Thompson Children's Hospital, Chattanooga
East Tennessee Children's Hospital, Knoxville
St. Jude Children's Research Hospital, Memphis
Kosair Children's Hospital, Louisville
Toledo Hospital, Toledo
Mercy Children's Hospital, Toledo
Cleveland Clinic Taussig Cancer Center, Cleveland
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Hurley Medical Center, Flint
Breslin Cancer Center at Ingham Regional Medical Center, Lansing
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids
Blank Children's Hospital, Des Moines
Midwest Children's Cancer Center at Children's Hospital of Wisconsin, Milwaukee
Marshfield Clinic - Marshfield Center, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
Masonic Cancer Center at University of Minnesota, Minneapolis
Mayo Clinic Cancer Center, Rochester
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood
Keyser Family Cancer Center at Advocate Hope Children's Hospital, Oak Lawn
Children's Memorial Hospital - Chicago, Chicago
Saint Jude Midwest Affiliate, Peoria
Cardinal Glennon Children's Hospital, St Louis
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis
Children's Mercy Hospital, Kansas City
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Oklahoma University Cancer Institute, Oklahoma City
Medical City Dallas Hospital, Dallas
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas
Cook Children's Medical Center - Fort Worth, Fort Worth
CCOP - Scott and White Hospital, Temple
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Texas Tech University Health Sciences Center School of Medicine - Amarillo, Amarillo
Covenant Children's Hospital, Lubbock
Children's Hospital Center for Cancer and Blood Disorders, Aurora
Presbyterian - St. Luke's Medical Center, Denver
Southern California Permanente Medical Group, Downey
Childrens Hospital Los Angeles, Los Angeles
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Children's Hospital and Research Center Oakland, Oakland
Lucile Packard Children's Hospital at Stanford University Medical Center, Palo Alto
Sutter Cancer Center, Sacramento
University of California Davis Cancer Center, Sacramento
Kaiser Permanente Medical Center - Oakland, Sacramento
Cancer Research Center of Hawaii, Honolulu
Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland
Children's Hospital and Regional Medical Center - Seattle, Seattle
Mary Bridge Children's Hospital and Health Center - Tacoma, Tacoma
Madigan Army Medical Center - Tacoma, Tacoma
Phoenix Children's Hospital, Phoenix
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson
City of Hope Comprehensive Cancer Center, Duarte
Children's Hospital Central California, Madera
Rady Children's Hospital - San Diego, San Diego
Connecticut Children's Medical Center, Hartford
Yale Cancer Center, New Haven
Children's National Medical Center, Washington D.C.
Walter Reed Army Medical Center, Washington D.C.
University of Florida Shands Cancer Center, Gainesville
Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando
MBCCOP - Medical College of Georgia Cancer Center, Augusta
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah
Tripler Army Medical Center, Tripler AMC
Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise
University of Illinois Cancer Center, Chicago
University of Chicago Cancer Research Center, Chicago
Advocate Lutheran General Cancer Care Center, Park Ridge
Simmons Cooper Cancer Institute, Springfield
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Holden Comprehensive Cancer Center at University of Iowa, Iowa City
Lucille P. Markey Cancer Center at University of Kentucky, Lexington
Tulane Cancer Center Office of Clinical Research, Alexandria
CancerCare of Maine at Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program at Barbara Bush Children's Hospital, Scarborough
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Floating Hospital for Children at Tufts - New England Medical Center, Boston
Massachusetts General Hospital, Boston
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute, Boston
C.S. Mott Children's Hospital at University of Michigan Medical Center, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
CCOP - Kalamazoo, Kalamazoo
University of Mississippi Cancer Clinic, Jackson
Children's Hospital, Omaha
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha
CCOP - Nevada Cancer Research Foundation, Las Vegas
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Hackensack University Medical Center Cancer Center, Hackensack
Overlook Hospital, Morristown
Saint Peter's University Hospital, New Brunswick
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick
Newark Beth Israel Medical Center, Newark
St. Joseph's Hospital and Medical Center, Paterson
University of New Mexico Cancer Center, Albuquerque
Albany Medical Center Hospital, Albany
Roswell Park Cancer Institute, Buffalo
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Wake Forest University Comprehensive Cancer Center, Winston-Salem
Akron Children's Hospital, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Rainbow Babies and Children's Hospital, Cleveland
Nationwide Children's Hospital, Columbus
Dayton Children's - Dayton, Dayton
Knight Cancer Institute at Oregon Health and Science University, Portland
Geisinger Cancer Institute at Geisinger Health, Danville
Penn State Children's Hospital, Hershey
Children's Hospital of Philadelphia, Philadelphia
St. Christopher's Hospital for Children, Philadelphia
Rhode Island Hospital Comprehensive Cancer Center, Providence
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls
Vanderbilt-Ingram Cancer Center, Nashville
Baylor University Medical Center - Houston, Houston
Methodist Children's Hospital of South Texas, San Antonio
Primary Children's Medical Center, Salt Lake City
Fletcher Allen Health Care - University Health Center Campus, Burlington
Inova Fairfax Hospital, Falls Church
Children's Hospital of The King's Daughters, Norfolk
Naval Medical Center - Portsmouth, Portsmouth
Virginia Commonwealth University Massey Cancer Center, Richmond
Providence Cancer Center at Sacred Heart Medical Center, Spokane
St. Vincent Hospital Regional Cancer Center, Green Bay
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
Children's & Women's Hospital of British Columbia, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Children's Health and Rehabilitation Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston
Children's Hospital of Western Ontario, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
Hopital Sainte Justine, Montreal
Allan Blair Cancer Centre at Pasqua Hospital, Regina
Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon
Centre Hospitalier Universitaire de Quebec, Québec
San Jorge Children's Hospital, Santurce
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK