Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line Therapy

PHASE3TerminatedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

June 30, 2007

Primary Completion Date

November 30, 2012

Study Completion Date

November 30, 2012

Conditions
Recurrent Colon CancerRecurrent Rectal CancerStage IVA Colon CancerStage IVA Rectal CancerStage IVB Colon CancerStage IVB Rectal Cancer
Interventions
DRUG

irinotecan hydrochloride

Given IV

DRUG

leucovorin calcium

Given IV

DRUG

fluorouracil

Given IV

BIOLOGICAL

cetuximab

Given IV

BIOLOGICAL

bevacizumab

Given IV

Trial Locations (382)

10940

Orange Regional Medical Center, Middletown

12801

Adirondack Cancer Center, Glens Falls

Glens Falls Hospital, Glens Falls

14215

Veterans Affairs Western New York Health Care System-Buffalo, Buffalo

14432

Finger Lakes Hematology and Oncology, Clifton Springs

15212

Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh

16801

Geisinger Medical Group, State College

17043

Central PA Hematology-Medical Oncology Associates PC, Lemoyne

18201

Geisinger Medical Center-Cancer Center Hazelton, Hazleton

18508

Hematology and Oncology Associates of North East Pennsylvania, Scranton

18711

Geisinger Wyoming Valley, Wilkes-Barre

19013

Associates In Hematology Oncology PC-Upland, Upland

19063

Riddle Hospital, Media

19107

Thomas Jefferson University Hospital, Philadelphia

19901

Bayhealth Medical Center at Kent General, Dover

20057

Lombardi Comprehensive Cancer Center at Georgetown University, Washington D.C.

21601

Memorial Hospital at Easton - Shore Regional Cancer Center, Easton

21701

Frederick Memorial Hospital, Frederick

22401

Fredericksburg Oncology Inc, Fredericksburg

25304

West Virginia University Charleston, Charleston

26101

Camden-Clark Memorial Hospital, Parkersburg

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28139

Rutherford Hospital, Rutherfordton

28374

FirstHealth of the Carolinas-Moore Regional Hosiptal, Pinehurst

28501

Kinston Medical Specialists PA, Kinston

28791

Margaret R Pardee Memorial Hospital, Hendersonville

29210

South Carolina Oncology Associates PA, Columbia

29303

Spartanburg Regional Medical Center, Spartanburg

Upstate Carolina CCOP, Spartanburg

29307

Greenville Health System Cancer Institute-Spartanburg, Spartanburg

29506

McLeod Regional Medical Center, Florence

29605

Greenville Health System Cancer Institute-Andrews, Greenville

Greenville Health System Cancer Institute-Butternut, Greenville

Greenville Health System Cancer Institute-Faris, Greenville

Greenville Memorial Hospital, Greenville

29615

Greenville Health System Cancer Instutite/Greenville CCOP, Greenville

29621

AnMed Health Hospital, Anderson

29640

Greenville Health System Cancer Institute-Easley, Easley

29646

Self Regional Healthcare, Greenwood

29650

Cancer Centers of the Carolinas-Greer Medical Oncology, Greer

Greenville Health System Cancer Institute-Greer, Greer

29672

Greenville Health System Cancer Institute-Seneca, Seneca

30033

Atlanta VA Medical Center, Decatur

Dekalb Medical Center, Decatur

30045

Gwinnett Medical Center, Lawrenceville

30060

Wellstar Kennestone Hospital, Marietta

30106

Well Star Cobb Hospital, Austell

30165

Harbin Clinic Medical Oncology and Clinical Research, Rome

30274

Southern Regional Medical Center, Riverdale

30309

Piedmont Hospital, Atlanta

30342

Atlanta Regional CCOP, Atlanta

Northside Hospital, Atlanta

Saint Joseph's Hospital of Atlanta, Atlanta

31603

South Georgia Medical Center, Valdosta

31904

John B Amos Cancer Center, Columbus

32207

Edna Williams Cancer Center at the Baptist Cancer Institute, Jacksonville

32796

Space Coast Cancer Centers-Titusville, Titusville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

38163

University of Tennessee - Memphis, Memphis

39581

Singing River Hospital, Pascagoula

40215

Doctors Carrol, Sheth, Raghavan, Louisville

43015

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43214

Riverside Methodist Hospital, Columbus

43215

Columbus CCOP, Columbus

Grant Medical Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43311

Mary Rutan Hospital, Bellefontaine

43402

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green

43410

North Coast Cancer Care-Clyde, Clyde

43420

Fremont Memorial Hospital, Fremont

43537

Saint Luke's Hospital, Maumee

Toledo Clinic Cancer Centers-Maumee, Maumee

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee

43560

Flower Hospital, Sylvania

43567

Fulton County Health Center, Wauseon

43606

The Toledo Hospital/Toledo Children's Hospital, Toledo

43608

Saint Vincent Mercy Medical Center, Toledo

43614

University of Toledo, Toledo

43616

Saint Charles Hospital, Oregon

Toledo Clinic Cancer Centers-Oregon, Oregon

43617

Toledo Community Hospital Oncology Program CCOP, Toledo

43623

Mercy Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

43701

Genesis HealthCare System, Zanesville

44035

Community Health Partners Regional Medical Center, Elyria

Hematology Oncology Center Incorporated, Elyria

44307

Akron General Medical Center, Akron

44708

Mercy Medical Center, Canton

44710

Aultman Health Foundation, Canton

44857

Fisher-Titus Medical Center, Norwalk

44870

Firelands Regional Medical Center, Sandusky

North Coast Cancer Care, Sandusky

44883

Mercy Hospital of Tiffin, Tiffin

44903

Mansfield General Hospital-MedCentral Health System, Mansfield

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45750

Marietta Memorial Hospital, Marietta

45804

Lima Memorial Hospital, Lima

46350

Indiana University Health La Porte Hospital, La Porte

46360

Franciscan Saint Anthony Health-Michigan City, Michigan City

46391

Michiana Hematology Oncology-PC Westville, Westville

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46515

Elkhart General Hospital, Elkhart

46563

Michiana Hematology Oncology PC-Plymouth, Plymouth

46601

Memorial Hospital of South Bend, South Bend

Michiana Hematology Oncology PC-South Bend, South Bend

46617

South Bend Clinic, South Bend

46628

Northern Indiana Cancer Research Consortium, South Bend

46845

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne

46904

Community Howard Regional Health, Kokomo

48060

Saint Joseph Mercy Port Huron, Port Huron

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48093

Saint John Macomb-Oakland Hospital, Warren

48106

Michigan Cancer Research Consortium Community Clinical Oncology Program, Ann Arbor

48124

Oakwood Hospital, Dearborn

48154

Saint Mary Mercy Hospital, Livonia

48162

Community Cancer Center of Monroe, Monroe

Mercy Memorial Hospital, Monroe

48202

Henry Ford Hospital, Detroit

48236

Saint John Hospital and Medical Center, Detroit

48502

Hurley Medical Center, Flint

48532

Genesys Regional Medical Center-West Flint Campus, Flint

48601

Saint Mary's of Michigan, Saginaw

48912

Sparrow Hospital, Lansing

49085

Lakeland Hospital, Saint Joseph

Marie Yeager Cancer Center, Saint Joseph

49120

Michiana Hematology Oncology PC-Niles, Niles

49201

Allegiance Health, Jackson

49221

Bixby Medical Center, Adrian

Hickman Cancer Center, Adrian

49423

Holland Community Hospital, Holland

49431

Green Bay Oncology - Escanaba, Escanaba

49442

Mercy Health Partners-Hackley Campus, Muskegon

49503

Grand Rapids Clinical Oncology Program, Grand Rapids

49801

Green Bay Oncology - Iron Mountain, Iron Mountain

50010

McFarland Clinic PC-William R Bliss Cancer Center, Ames

50307

Mercy Capitol, Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Iowa Oncology Research Association CCOP, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Medical Oncology and Hematology Associates-Laurel, Des Moines

Mercy Medical Center - Des Moines, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

50702

Covenant Medical Center, Waterloo

51101

Siouxland Hematology Oncology Associates, Sioux City

51104

Mercy Medical Center-Sioux City, Sioux City

Saint Luke's Regional Medical Center, Sioux City

52403

Cedar Rapids Oncology Association, Cedar Rapids

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

52722

Hematology Oncology Associates-Quad Cities, Bettendorf

53097

Columbia Saint Mary's Hospital - Ozaukee, Mequon

53121

Aurora Cancer Care-Southern Lakes, Elkhorn

53211

Columbia Saint Mary's Water Tower Medical Commons, Milwaukee

53215

Medical Consultants Limited, Milwaukee

53547

Mercy Health System, Janesville

54143

Bay Area Medical Center, Marinette

54154

Green Bay Oncology - Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54235

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay

54301

Saint Vincent Hospital, Green Bay

54303

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay

Saint Mary's Hospital, Green Bay

54702

Midelfort Clinic-Clairemont Campus, Eau Claire

54703

Mayo Clinic Health System Eau Claire Hospital - Luther Campus, Eau Claire

55101

Regions Hospital, Saint Paul

55102

Saint Joseph's Hospital - Healtheast, Saint Paul

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology and Hematology PA-Woodbury, Woodbury

Woodwinds Health Campus, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55355

Meeker County Memorial Hospital, Litchfield

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

Virginia Piper Cancer Institute, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro-Minnesota CCOP, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview-Southdale Hospital, Edina

55805

Essentia Health Duluth Clinic CCOP, Duluth

Essentia Health Saint Mary's Medical Center, Duluth

Miller-Dwan Hospital, Duluth

55905

Mayo Clinic, Rochester

56001

Mayo Clinic Health Systems-Mankato, Mankato

56201

Rice Memorial Hospital, Willmar

56537

Etzell, Paul S MD (UIA Investigator), Fergus Falls

Swenson, Wade II, MD (UIA Investigator), Fergus Falls

57701

Rapid City Regional Hospital, Rapid City

58201

Altru Cancer Center, Grand Forks

58501

Bismarck Cancer Center, Bismarck

Mid Dakota Clinic, Bismarck

Saint Alexius Medical Center, Bismarck

Sanford Bismarck Medical Center, Bismarck

59101

Montana Cancer Consortium CCOP, Billings

Northern Rockies Radiation Oncology Center, Billings

Saint Vincent Healthcare, Billings

59102

Hematology-Oncology Centers of the Northern Rockies PC, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Berdeaux, Donald MD (UIA Investigator), Great Falls

Great Falls Clinic, Great Falls

59501

Northern Montana Hospital, Havre

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Deaconess Cancer Center, Bozeman

Bozeman Deaconess Hospital, Bozeman

59801

Community Medical Hospital, Missoula

59802

Montana Cancer Specialists, Missoula

Saint Patrick Hospital - Community Hospital, Missoula

59804

Guardian Oncology and Center for Wellness, Missoula

59901

Glacier Oncology PLLC, Kalispell

Kalispell Medical Oncology, Kalispell

Kalispell Regional Medical Center, Kalispell

60435

Joliet Oncology-Hematology Associates Limited, Joliet

60504

Rush - Copley Medical Center, Aurora

60525

Adventist La Grange Memorial Hospital, La Grange

60631

Resurrection Healthcare, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Ottawa Regional Hospital and Healthcare Center, Ottawa

61354

Illinois Valley Hospital, Peru

61356

Perry Memorial Hospital, Princeton

61362

Saint Margaret's Hospital, Spring Valley

61401

Galesburg Cottage Hospital, Galesburg

Illinois CancerCare Galesburg, Galesburg

61455

Mcdonough District Hospital, Macomb

61520

Graham Hospital Association, Canton

61530

Eureka Hospital, Eureka

61554

Pekin Cancer Treatment Center, Pekin

Pekin Hospital, Pekin

61603

Methodist Medical Center of Illinois, Peoria

61614

Proctor Hospital, Peoria

61615

Illinois CancerCare-Peoria, Peoria

Illinois Oncology Research Association CCOP, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

Saint Joseph Medical Center, Bloomington

61747

Hopedale Medical Complex - Hospital, Hopedale

61761

Bromenn Regional Medical Center, Normal

Community Cancer Center Foundation, Normal

61801

Carle Cancer Center, Urbana

Carle Clinic-Urbana Main, Urbana

62321

Memorial Hospital, Carthage

62401

Crossroads Cancer Center, Effingham

Saint Anthony Memorial Hospital, Effingham

62526

Decatur Memorial Hospital, Decatur

62644

Mason District Hospital, Havana

63110

Saint Louis University Hospital, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Center for Cancer Care and Research, St Louis

63701

Southeast Missouri Hospital, Cape Girardeau

65201

Veterans Administration, Columbia

65212

University of Missouri - Ellis Fischel, Columbia

65702

Promise Regional Medical Center-Hutchinson, Hutchinson

65804

Mercy Hospital Springfield, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66061

Olathe Cancer Center, Olathe

66160

University of Kansas Medical Center, Kansas City

66604

Stormont-Vail Regional Health Center, Topeka

66606

Saint Francis Hospital and Medical Center - Topeka, Topeka

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

66762

Via Christi Hospital-Pittsburg, Pittsburg

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Cancer Center of Kansas - Main Office, Wichita

Via Christi Regional Medical Center, Wichita

Wichita CCOP, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

Salina Regional Health Center, Salina

67601

Hays Medical Center, Hays

67801

Cancer Center of Kansas - Dodge City, Dodge City

67901

Cancer Center of Kansas-Liberal, Liberal

68510

Nebraska Cancer Research Center, Lincoln

68847

Good Samaritan Hospital, Kearney

70806

Baton Rouge General Medical Center, Baton Rouge

72903

Saint Edward Mercy Medical Center, Fort Smith

76508

Scott and White Memorial Hospital, Temple

79106

The Don and Sybil Harrington Cancer Center, Amarillo

80012

The Medical Center of Aurora, Aurora

80033

Exempla Lutheran Medical Center, Wheat Ridge

80113

Swedish Medical Center, Englewood

80124

Sky Ridge Medical Center, Lone Tree

80210

Porter Adventist Hospital, Denver

80218

Exempla Saint Joseph Hospital, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

80220

Rose Medical Center, Denver

80228

Saint Anthony Hospital, Lakewood

80229

North Suburban Medical Center, Thornton

80301

Boulder Community Hospital, Boulder

80501

Longmont United Hospital, Longmont

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

80909

Memorial Hospital Colorado Springs, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81502

Saint Mary's Hospital and Regional Medical Center, Grand Junction

82609

Rocky Mountain Oncology, Casper

82801

Welch Cancer Center, Sheridan

90033

University of Southern California, Los Angeles

91010

City of Hope Medical Center, Duarte

91204

Glendale Memorial Hospital and Health Center, Glendale

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

93449

Palchak David MD, Pismo Beach

94533

Northbay Cancer Center, Fairfield

94538

Valley Medical Oncology Consultants-Fremont, Fremont

94545

Saint Rose Hospital, Hayward

94546

East Bay Radiation Oncology Center, Castro Valley

Eden Hospital Medical Center, Castro Valley

Valley Medical Oncology Consultants-Castro Valley, Castro Valley

94588

Valley Care Health System - Pleasanton, Pleasanton

Valley Medical Oncology Consultants, Pleasanton

94602

Highland General Hospital, Oakland

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Breast Surgeons Inc, Oakland

Bay Area Tumor Institute CCOP, Oakland

Larry G Strieff MD Medical Corporation, Oakland

Tom K Lee Inc, Oakland

94806

Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo

94904

Marin General Hospital, Greenbrae

95661

Sutter Roseville Medical Center, Roseville

95817

UC Davis Comprehensive Cancer Center, Sacramento

95901

Fremont - Rideout Cancer Center, Marysville

96161

Tahoe Forest Cancer Center, Truckee

97216

Adventist Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

98104

Harborview Medical Center, Seattle

Minor and James Medical PLLC, Seattle

98109

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle

98112

Group Health Cooperative-Seattle, Seattle

98122

The Polyclinic, Seattle

98195

University of Washington Medical Center, Seattle

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98274

Skagit Valley Hospital, Mount Vernon

98284

United General Hospital, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98801

Wenatchee Valley Medical Center, Wenatchee

99202

Cancer Care Northwest - Spokane South, Spokane

99218

Evergreen Hematology and Oncology PS, Spokane

99336

Columbia Basin Hematology and Oncology PLLC, Kennewick

80224-2522

Colorado Cancer Research Program CCOP, Denver

06050

The Hospital of Central Connecticut, New Britain

32224-9980

Mayo Clinic in Florida, Jacksonville

60612-3785

John H Stroger Jr Hospital of Cook County, Chicago

62781-0001

Memorial Medical Center, Springfield

46514-2098

Elkhart Clinic, Elkhart

46545-1470

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

04330

Harold Alfond Center for Cancer Care, Augusta

04401

Eastern Maine Medical Center, Bangor

02703

Sturdy Memorial Hospital, Attleboro

02118

Boston Medical Center, Boston

48106-0995

Saint Joseph Mercy Hospital, Ann Arbor

48341-2985

Saint Joseph Mercy Oakland, Pontiac

59107-7000

Billings Clinic, Billings

08060

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County, Mount Holly

07871

Sparta Cancer Treatment Center, Sparta

08043

Virtua West Jersey Hospital Voorhees, Voorhees Township

10467-2490

Montefiore Medical Center, The Bronx

17822-2001

Geisinger Medical Center, Danville

19023-1291

Mercy Fitzgerald Hospital, Darby

98122-4307

Swedish Medical Center-First Hill, Seattle

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

Sponsors
All Listed Sponsors
collaborator

North Central Cancer Treatment Group

NETWORK

collaborator

Cancer and Leukemia Group B

NETWORK

collaborator

Eastern Cooperative Oncology Group

NETWORK

collaborator

NCIC Clinical Trials Group

NETWORK

lead

National Cancer Institute (NCI)

NIH