NCT00498953View on ClinicalTrials.gov

Combination Chemotherapy and Radiation Therapy With or Without Lapatinib in Treating Patients With Locally Advanced Cancer of the Larynx or Hypopharynx

PHASE1/PHASE2CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

May 31, 2007

Primary Completion Date

November 30, 2008

Study Completion Date

March 31, 2009

Conditions

Head and Neck Cancer

Interventions

DRUG

carboplatin

DRUG

cisplatin

DRUG

docetaxel

DRUG

fluorouracil

DRUG

lapatinib ditosylate

GENETIC

cytogenetic analysis

GENETIC

fluorescence in situ hybridization

GENETIC

in situ hybridization

GENETIC

polymerase chain reaction

GENETIC

reverse transcriptase-polymerase chain reaction

OTHER

immunohistochemistry staining method

OTHER

laboratory biomarker analysis

PROCEDURE

conventional surgery

PROCEDURE

neoadjuvant therapy

RADIATION

fludeoxyglucose F 18

RADIATION

radiation therapy

Trial Locations (1)

1000

Institut Jules Bordet, Brussels

All Listed Sponsors

lead

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

NCT00498953 - Combination Chemotherapy and Radiation Therapy With or Without Lapatinib in Treating Patients With Locally Advanced Cancer of the Larynx or Hypopharynx | Biotech Hunter | Biotech Hunter