Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy

PHASE4CompletedINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

February 28, 2009

Primary Completion Date

September 30, 2015

Study Completion Date

September 30, 2015

Conditions
IgA Nephropathy
Interventions
DRUG

Intravenous Rituximab

"Rituximab Therapy \[27 Patients\]~* Rituximab 1 gm IV on Treatment Day 1~* Rituximab 1 gm IV on Treatment Day 15~* Rituximab 1 gm IV on Treatment Day 168~* Rituximab 1 gm IV on Treatment Day 182"

DRUG

ACE/ARB

ACE inhibitors and /or ARBs will be used to achieve a blood pressure goal of \<130/80 millimeters of mercury (mmHg). Patients not attaining the target blood pressure with an ACE inhibitor or ARB alone should be treated with the combination of ACE inhibitor (ACEi) + ARB

DIETARY_SUPPLEMENT

Omega-3 Fatty Acid Fish Oil Supplement

Omega-3 Fatty Acid Fish Oil Supplement 3.6 gm eicosapentaenoic acid (EPA)/day

Trial Locations (5)

10032

Columbia University Medical Center, New York

27599

University of North Carolina, Chapel Hill, Chapel Hill

55905

Mayo Clinic, Rochester

94304

Stanford University, San Francisco

43210-1063

The University of Ohio, Columbus

Sponsors

Lead Sponsor

Collaborators (2)

All Listed Sponsors
collaborator

Ohio State University

OTHER

collaborator

Stanford University

OTHER

collaborator

University of North Carolina, Chapel Hill

OTHER

collaborator

Columbia University

OTHER

collaborator

Genentech, Inc.

INDUSTRY

collaborator

Biogen

INDUSTRY

lead

Mayo Clinic

OTHER