NCT00496769View on ClinicalTrials.gov

A Phase III Study of Apixaban in Patients With Atrial Fibrillation

PHASE3CompletedINTERVENTIONAL
Enrollment

6,421

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

November 30, 2010

Study Completion Date

May 25, 2017

Conditions
Atrial Fibrillation
Interventions
DRUG

Apixaban

Tablets, oral, 5 mg (2.5 mg in patients meeting any 2 of the following criteria: 80 years of age and older, weight of 60 kilograms or less, and a serum creatinine level of 1.5 mg/dL or higher), twice daily, up to 156 weeks

DRUG

Acetylsalicylic acid

Tablets, oral, 81-324 mg, once daily, up to 156 weeks

Trial Locations (503)

111

Local Institution, Taipei

220

Local Institution, Taipei

402

Local Institution, Taichung

704

Local Institution, Tainan City

807

Local Institution, Kaohsiung City

1000

Local Institution, Manila

1070

Local Institution, Brussels

1090

Local Institution, Brussels

1221

Local Institution, Buenos Aires

1450

Local Institution, Alberton

1780

Local Institution, City of Muntinlupa

1846

Local Institution, Adrogué

2000

Local Institution, Rosario

Local Institution, Frederiksberg

2139

Local Institution, Concord

2250

Local Institution, Gosford

2300

Local Institution, Turnhout

2450

Local Institution, Coffs Harbour

2747

Local Institution, Kingswood

2900

Local Institution, Laoag

2930

Local Institution, Brasschaat

3000

Local Institution, Santa Fe

3220

Local Institution, Geelong

3400

Local Institution, Corrientes

3600

Local Institution, Genk

3602

Local Institution, Kongsberg

4020

Local Institution, Linz

4021

Local Institution, Kippa-Ring

4024

Local Institution, Biñan

4064

Local Institution, Milton

4066

Local Institution, Auchenflower

4102

Local Institution, Woolloongabba

4114

Local Institution, Cavite

4400

Local Institution, Naga

4500

Local Institution, Huy

5000

Local Institution, Córdoba

5016

Local Institution, Córdoba

5020

Local Institution, Salzburg

5145

Local Institution, Fyllingsdal

6027

Local Institution, Joondalup

6700

Local Institution, Esbjerg

6850

Local Institution, Worcester

7130

Local Institution, Somerset West

7350

Local Institution, Oberpullendorf

7530

Local Institution, Bellville, Cape Town

7925

Local Institution, Cape Town

8000

Local Institution, Arhus C

8036

Local Institution, Graz

8800

Local Institution, Roeselare

9000

Local Institution, Cagayan de Oro

9200

Local Institution, Iligan City

9300

Local Institution, Aalst

Local Institution, Bloemfontein

9301

Local Institution, Bloemfontein

9840

Local Institution, De Pinte

10117

Local Institution, Berlin

10430

Local Institution, Jakarta

10507

Local Institution, Taipei

10567

Nyu Hudson Valley Cardiology, Cortlandt Manor

10990

Local Institution, Pulau Pinang

11501

Long Island Heart Associates, Mineola

12099

Local Institution, Berlin

12180

Capital Cardiology Associates, Troy

12211

Capital Cardiology Associates, Albany

12866

Dr William Kufs, Saratoga Springs

13059

Local Institution, Campinas

13100

Local Institution, Safed

13310

Local Institution, Jakarta

13353

Local Institution, Berlin

13750

Local Institution, Jakarta Timur

14080

Local Institution, Mexico City

15015

Local Institution, San Jose- Do Rio Preto

Local Institution, São José do Rio Preto

15025

Local Institution, São José do Rio Preto

15090

Local Institution, São José do Rio Preto

16000

Local Institution, Nazareth

16100

Local Institution, Nazareth

16132

Local Institution, Genova

17515

Local Institution, Marília

17519

Local Institution, Marília

18101

Local Institution, Afula

18600

Local Institution, Botucatu

18960

Grand View - Lehigh Valley Health Services, Sellersville

19047

Comprehensive Cardiology Consultants, Langhorne

19067

Cardiology Consultants Of Philadelphia, Yardley

19380

West Chester Cardiology, West Chester

20127

Local Institution, Aguascalientes

20230

Local Institution, Aguascalientes

20551

Local Institution, Rio de Janeiro

21804

Peninsula Cardiology Associates, P.A., Salisbury

22291

Local Institution, Hamburg

22299

Local Institution, Hamburg

22527

Local Institution, Hamburg

23510

Sentara York Clinical Research, Norfolk

24014

Roanoke Heart Institute, Plc, Roanoke

24153

Salem Veterans Administration Medical Center, Salem

25137

Local Institution, Padang

26871

Local Institution, Papenburg

27003

Local Institution, Lugo

27293

Terry V. Arnold, Md, Lexington

27330

Sanford Cardiology, Sanford

28007

Local Institution, Madrid

28034

Local Institution, Madrid

28374

Pinehurst Medical Clinic, Inc, Pinehurst

29425

Medical University Of South Carolina, Charleston

29650

Internal Medicine Of Greer, Greer

29906

Lowcountry Medical Group, Llc, Beaufort

30126

Local Institution, Palembang

30150

Local Institution, Belo Horizonte

31096

Local Institution, Haifa

31203

Local Institution, Chihuahua City

31406

Southeast Regional Research Group, Savannah

31904

Southeast Regional Research Group, Columbus

32100

Local Institution, Isparta

32114

Kim A. Klancke, Md, Daytona Beach

32200

Local Institution, Thebes

32204

St. Vincent'S Ambulatory Care, Inc, Jacksonville

32250

Baptist Heart Specialists, Jacksonville Beach

32901

Michael F. Lesser, Md, Facc Osler Medical Inc., Melbourne

33038

Local Institution, San Daniele de Friuli (ud)

33321

The Broward Heart Group, Pa, Tamarac

33744

Bay Pines Va Healthcare System, Bay Pines

33756

Research Alliance, Inc., Clearwater

The Heart & Vascular Institute Of Florida, Clearwater

33900

Local Institution, Tampere

33908

The Heart Group Pl, Fort Myers

34080

Local Institution, Durango

34121

Local Institution, Kassel

34239

Cardiovascular Center Of Sarasota, Sarasota

34304

Local Institution, Istanbul

34362

Local Institution, Haifa

34390

Local Institution, Istanbul

36608

Mobile Heart Specialists, Pc, Mobile

37916

Knoxville Heart Group, Knoxville

38010

Local Institution, Uberaba

38025

Local Institution, Uberaba

38043

Local Institution, Grenoble

38100

Local Institution, Hadera

38801

Tupelo Neurology Clinic, Pa, Tupelo

39112

Local Institution, Magdeburg

39326

Local Institution, Wolmirstedt

39570

Local Institution, Acapulco de Juárez

40100

Local Institution, Jyväskylä

40144

Local Institution, Salvador

40161

Local Institution, Bandung

41810

Local Institution, Salvador

43210

Davis Heart & Lung Research Institute, Columbus

44600

Local Institution, Guadalajara

44670

Local Institution, Guadalajara

44710

Ira R. Friedlander, M.D., Canton

45147

Local Institution, Essen

45200

Local Institution, Zapopan

46017

Local Institution, Valencia

46237

Indiana Heart Physicians, Inc., Indianapolis

46290

The Care Group, Llc, Indianapolis

48202

Henry Ford Hospital K-15, Detroit

48307

Academic Cardiology Associates, Rochester Hills

49005

Local Institution, Dnipropetrovsk

49100

Local Institution, Petah Tikva

49325

Local Institution, Cholet

49707

Great Lakes Heart Center Of Alpena, Alpena

49770

Michigan Heart And Vascular Specialists, Petoskey

50586

Local Institution, Kuala Lumpur

51067

Local Institution, Cologne

52206

Local Institution, Langres

52975

Local Institution, Ciudad López Mateos

53115

Local Institution, Bonn

53583

Local Institution, Giv‘atayim

54449

Marshfield Clinic, Marshfield

55043

Local Institution, Lido di Camaiore

55116

Local Institution, Mainz

55131

Local Institution, Mainz

55284

Local Institution, Yogyakarta

56000

Local Institution, Cheras

58100

Local Institution, Holon

58455

Local Institution, Witten

59020

Local Institution, Natal

59100

Local Institution, Kuala Lumpur

59901

Glacier View Cardiology, Pc, Kalispell

60064

North Chicago Va Medical Center, North Chicago

60286

Local Institution, Surabaya

60504

Fox Valley Clinical Research Center, Llc, Aurora

60590

Local Institution, Frankfurt am Main

61002

Local Institution, Kharkiv

61018

Local Institution, Kharkiv

61029

Local Institution, Kharkiv

61115

Local Institution, Kharkiv

61176

Local Institution, Kharkiv

63100

Local Institution, Ascoli Piceno

64239

Local Institution, Tel Aviv

64240

Local Institution, Monterrey

65111

Local Institution, Malang

65201

Missouri Cardiovascular Specialists, Columbia

65212

University Of Missouri, Columbia

66013

Local Institution, Chieti

66087

Local Institution, Belém

67502

Hutchinson Clinic, Pa, Hutchinson

68167

Local Institution, Mannheim

69115

Local Institution, Heidelberg

69120

Local Institution, Heidelberg

70506

Dr. Jeffrey Chen, Lafayette

71100

Local Institution, Kırıkkale

73112

Integris Cardiovascular Physicians, Oklahoma City

73135

South Oklahoma Heart Research, Oklahoma City

75018

Local Institution, Paris

76000

Local Institution, Querétaro

78200

Local Institution, San Luis Potosí City

78240

Local Institution, San Luis Potosi, Slp

78278

Local Institution, Ashkelon

80010

Local Institution, Curitiba

80020

Local Institution, Culiacán

80100

Local Institution, Johor Bahru

80114

Local Institution, Denpasar

80142

Local Institution, Abbeville

80730

Local Institution, Curitiba

81013

Local Institution, Albi

83041

Local Institution, Toulon

83114

Local Institution, Donetsk

83190

Local Institution, Hermosillo

83430

Local Institution, Campina Grande do Sul

85710

Southwest Heart, Tucson

86170

Local Institution, Isernia

87015

Local Institution, Maringá

88103

Local Institution, São José

89010

Local Institution, Blumenau

90020

Local Institution, Porto Alegre

90034

Kaiser Permanente Medical Center, West Los Angeles, Los Angeles

90035

Local Institution, Porto Alegre

90110

Local Institution, Porto Alegre

90127

Local Institution, Palermo

90610

Local Institution, Porto Alegre

90620

Local Institution, Porto Alegre

91020

Local Institution, Jalapa

91350

Local Institution, Porto Alegre

91767

Yogesh K. Paliwal Md, Pomona

92064

San Diego Managed Care Group, Poway

92083

North County Internal Medicine, Vista

92103

University Of California, San Diego, San Diego

92262

Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group, Palm Springs

92801

Cardiology Consultants Of Orange County Med. Group Inc, Anaheim

93053

Local Institution, Regensburg

93586

Local Institution, Kuching

95405

Santa Rosa Cardiology, Santa Rosa

97123

Hillsboro Cardiology Pc, Hillsboro

97205

The Portland Clinic, Llp, Portland

97401

Oregon Medical Group - Clinical Research, Eugene

99362

Walla Walla Clinic, Walla Walla

100020

Local Institution, Beijing

100029

Local Institution, Beijing

100037

Local Institution, Beijing

100038

Local Institution, Beijing

100088

Local Institution, Beijing

100853

Local Institution, Beijing

101990

Local Institution, Moscow

105066

Local Institution, Moscow

109240

Local Institution, Moscow

110001

Local Institution, Shenyang

111539

Local Institution, Moscow

116033

Local Institution, Dalian

117485

Local Institution, Moscow

119121

Local Institution, Moscow

121356

Local Institution, Moscow

121552

Local Institution, Moscow

125284

Local Institution, Moscow

125367

Local Institution, Moscow

127644

Local Institution, Moscow

129301

Local Institution, Moscow

129336

Local Institution, Moscow

143000

Local Institution, Moscow

150062

Local Institution, Yaroslavl

169609

Local Institution, Singapore

170036

Local Institution, Tver'

190000

Local Institution, Saint Petersburg

191025

Local Institution, Saint Petersburg

193079

Local Institution, Saint Petersburg

193144

Local Institution, Saint Petersburg

194156

Local Institution, Saint Petersburg

194291

Local Institution, Saint Petersburg

195112

Local Institution, Saint Petersburg

197198

Local Institution, Saint Petersburg

200025

Local Institution, Shanghai

200433

Local Institution, Shanghai

215006

Local Institution, Suzhou

226003

Local Institution, Lucknow

248007

Local Institution, Kaluga

266071

Local Institution, Qingdao

302001

Local Institution, Jaipur

308433

Local Institution, Singapore

350042

Local Institution, Krasnodar

380060

Local Institution, Ahmedabad

390026

Local Institution, Ryazan

400007

Local Institution, Mumbai

400052

Local Institution, Mumbai

410028

Local Institution, Saratov

410054

Local Institution, Saratov

411001

Local Institution, Pune

411030

Local Institution, Pune

420012

Local Institution, Kazan'

422002

Local Institution, Nashik

430060

Local Institution, Wuhan

440012

Local Institution, Nagpur

Local Institution, Dhantoli

443070

Local Institution, Samara

443095

Local Institution, Samara

452001

Local Institution, Indore

454136

Local Institution, Chelyabinsk

500001

Local Institution, Hyderabad

510180

Local Institution, Guangzhou

529889

Local Institution, Singapore

560034

Local Institution, Bangalore

560052

Local Institution, Bangalore

560054

Local Institution, Banglore

570020

Local Institution, Mysore

600081

Local Institution, Chennai

603035

Local Institution, Nizhny Novgorod

610041

Local Institution, Chengdu

614097

Local Institution, Perm

614107

Local Institution, Perm

620109

Local Institution, Yekaterinburg

620144

Local Institution, Yekaterinburg

625023

Local Institution, Tyumen

630047

Local Institution, Novosibirsk

634012

Local Institution, Tomsk

650002

Local Institution, Kemerovo

656055

Local Institution, Barnaul

686016

Local Institution, Kottayam

768828

Local Institution, Singapore

2570017

Local Institution, Viña del Mar

4720000

Local Institution, Victoria

4781173

Local Institution, Temuco

5111847

Local Institution, Valdivia

7500520

Local Institution, Santiago

7600448

Local Institution, Santiago

8330074

Local Institution, Santiago

8360160

Local Institution, Santiago

8900085

Local Institution, Santiago

06437

Cardiology Associates Of New Haven,Pc, Guilford

06905

Stamford Therapeutics Consortium, Stamford

01830

Pentucket Medical Associates, Haverhill

08822

Hunterdon Cardiovascular Associates, Flemington

C1119ACN

Local Institution, Autonoma Buenos Aires

B8000FTD

Local Institution, Bahía Blanca

B7540GHD

Local Institution, Coronel Suárez

B1706AJU

Local Institution, Haedo

B1900AXI

Local Institution, La Plata

B1902COS

Local Institution, La Plata

B7600FZN

Local Institution, Mar del Plata

B1722COV

Local Institution, Merlo

B1704ETD

Local Institution, Ramos Mejía

X2400MHC

Local Institution, San Francisco

Y4600ABF

Local Institution, San Salvador de Jujuy

B2800DGH

Local Institution, Zárate

S2000CVB

Local Institution, Rosario

S2001ODA

Local Institution, Rosario

T4000ICL

Local Institution, San Miguel de Tucumán

T4000JCU

Local Institution, San Miguel de Tucumán

X5000AAX

Local Institution, Córdoba

X5000EPU

Local Institution, Córdoba

X5000EVQ

Local Institution, Córdoba

X5009BSN

Local Institution, Córdoba

A4406CLA

Local Institution, Salta

040112-180

Local Institution, São Paulo

04012

Local Institution, São Paulo

04038

Local Institution, São Paulo

05403

Local Institution, São Paulo

V3L 3W4

Local Institution, New Westminster

R2V 4W3

Local Institution, Winnipeg

L6W 2X7

Local Institution, Brampton

L7M 4Y1

Local Institution, Burlington

N1R 6V6

Local Institution, Cambridge

N1R 7R1

Local Institution, Cambridge

P3C 5K7

Local Institution, Greater Sudbury

P3E 2N8

Local Institution, Greater Sudbury

L3M 1P3

Local Institution, Grimsby

L8L 2X2

Local Institution, Hamilton

L8M 1K7

Local Institution, Hamilton

L1H 1B9

Local Institution, Oshawa

L1J 2J9

Local Institution, Oshawa

K1Y 4W7

Local Institution, Ottawa

N7T 4X3

Local Institution, Sarnia

M4N 3M5

Local Institution, Toronto

M5B 1W8

Local Institution, Toronto

M9N 1W4

Local Institution, Weston

J4V 2G8

Local Institution, Greenfield Park

H1T 1C8

Local Institution, Montreal

H2K 4L5

Local Institution, Montreal

H2W 1T8

Local Institution, Montreal

G1J 1Z6

Local Institution, Québec

G5Y 4W1

Local Institution, Saint Georges Beauce

J7Z 5T3

Local Institution, Saint-Jérôme

J4P 2H4

Local Institution, Saint-Lambert

J6V 2H2

Local Institution, Terrebonne

H3Z 2M6

Local Institution, Westmount

S7L OY7

Local Institution, Saskatoon

Unknown

Local Institution, Osorno

Local Institution, Medellín

Local Institution, Barranquilla

Local Institution, Bucaramanga

Local Institution, Santiago de Cali

Local Institution, Bogotá

Local Institution, Shatin

Local Institution, Chai Wan

Local Institution, Hong Kong

050082

Local Institution, Shijiazhuang

656 91

Local Institution, Brno

736 01

Local Institution, Havirov - Mesto

377 38

Local Institution, Jindřichův Hradec

272 59

Local Institution, Kladno

767 55

Local Institution, Kroměříž

289 03

Local Institution, Městec Králové

702 00

Local Institution, Ostrava

397 01

Local Institution, Písek

110 00

Local Institution, Prague

128 08

Local Institution, Prague

150 00

Local Institution, Prague

535 01

Local Institution, Přelouč

261 26

Local Institution, Příbram

274 01

Local Institution, Slaný

562 18

Local Institution, Ústí nad Orlicí

02740

Local Institution, Espoo

00029 HUS

Local Institution, Helsinki

FI-70100

Local Institution, Kuopio

04203

Local Institution, Sisteron

06097

Local Institution, Halle

04104

Local Institution, Leipzig

01587

Local Institution, Riesa

151 23

Local Institution, Athens

41 221

Local Institution, Larissa

334 003

Local Institution, Bikaner

06126

Local Institution, Perugia

07100

Local Institution, Sassari

06726

Local Institution, Mexico City

0264

Local Institution, Oslo

0450

Local Institution, Oslo

42-200

Local Institution, Częstochowa

82-300

Local Institution, Elblag

81-423

Local Institution, Gdynia

44-100

Local Institution, Gliwice

88-140

Local Institution, Gniewkowo

05-825

Local Institution, Grodzisk Mazowiecki

88-100

Local Institution, Inowrocław

25-736

Local Institution, Kielce

30-092

Local Institution, Krakow

31-501

Local Institution, Krakow

91-302

Local Institution, Lodz

97-300

Local Institution, Piotrkow Trybunalski

60-539

Local Institution, Poznan

24-100

Local Institution, Puławy

09-402

Local Institution, Płock

41-100

Local Institution, Siemianowice Śląskie

96-100

Local Institution, Skierniewice

33-100

Local Institution, Tarnów

00-217

Local Institution, Warsaw

03-242

Local Institution, Warsaw

04-073

Local Institution, Warsaw

07-100

Local Institution, Węgrów

41-800

Local Institution, Zabrze

58-130

Local Institution, Żarów

0041

Local Institution, Pretoria

411-773

Local Institution, Goyang-si

471-701

Local Institution, Guri-si

463-707

Local Institution, Seongnam-si

602-702

Local Institution, Busan

700-721

Local Institution, Daegu

302-718

Local Institution, Daejeon

501-757

Local Institution, Gwangju

110-744

Local Institution, Seoul

130-709

Local Institution, Seoul

143-729

Local Institution, Seoul

03186

Local Institution, Torrevieja

08907

Local Institution, L'Hospitalet de Llobregat

02006

Local Institution, Albacete

416 85

Local Institution, Gothenburg

417 17

Local Institution, Gothenburg

431 80

Local Institution, Mölndal

111 57

Local Institution, Stockholm

118 83

Local Institution, Stockholm

141 86

Local Institution, Stockholm

751 85

Local Institution, Uppsala

01023

Local Institution, Kyiv

02091

Local Institution, Kyiv

02660

Local Institution, Kyiv

03680

Local Institution, Kyiv

04107

Local Institution, Kyiv

04114

Local Institution, Kyiv

AB25 2ZN

Local Institution, Aberdeen

S44 5BL

Local Institution, Chesterfield

SS16 5NL

Local Institution, Basildon

RM7 0AG

Local Institution, Romford

KY2 5AH

Local Institution, Kirkcaldy

SW17 ORE

Local Institution, London

G11 6NT

Local Institution, Glasgow

G51 4TF

Local Institution, Glasgow

FY3 8NR

Local Institution, Blackpool

NN1 5BD

Local Institution, Northampton

S18 0BD

Local Institution, Worksop

BT63 5QQ

Local Institution, Craigavon

PA2 9PN

Local Institution, Paisley

S75 2EP

Local Institution, Barnsley

FK5 4WR

Local Institution, Larbert

NE2 4HH

Local Institution, Newcastle Upon

B18 7QH

Local Institution, Birmingham

PO19 6SE

Local Institution, Chichester

Sponsors

Collaborators (1)

Pfizer
All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY

NCT00496769 - A Phase III Study of Apixaban in Patients With Atrial Fibrillation | Biotech Hunter | Biotech Hunter