787
Participants
Start Date
July 26, 2007
Primary Completion Date
November 30, 2011
Study Completion Date
November 30, 2011
Bevacizumab
Bevacizumab was administered at a dose of 15 mg/kg IV on Day 1 of each 21-day cycle for 8 cycles or at a dose 10 mg/kg IV on Day 1 of each 14-day cycle for 8 cycles. The cycle duration (14- or 21-day) was chosen by each center prior to initiation of the study and was the same for all patients enrolled at that center.
Rituximab
Rituximab was administered at a dose of 375 mg/m\^2 IV on Day 1 of each 14- or 21-day cycle for 8 cycles. The cycle duration (14- or 21-day) was chosen by each center prior to initiation of the study and was the same for all patients enrolled at that center.
CHOP
Cyclophosphamide was administered at a dose of 750 mg/m\^2 IV on Day 1 of each cycle. Doxorubicin was administered at a dose of 50 mg/m\^2 IV on Day 1 of each cycle. Vincristine was administered at a dose of 1.4 mg/m\^2 IV (maximum of 2 mg) on Day 1 of each cycle. Prednisone was administered at a dose of 100 mg orally on Days 1-5 of each cycle. All 4 drugs were administered either every 21 days for 8 cycles or every 14 days for 6 cycles. The cycle duration (14- or 21-day) was chosen by each center prior to initiation of the study and was the same for all patients enrolled at that center.
Placebo
Placebo to bevacizumab was administered on Day 1 of each 14- or 21-day cycle for 8 cycles. The cycle duration (14- or 21-day) was chosen by each center prior to initiation of the study and was the same for all patients enrolled at that center.
Hospital Nacional Edgardo Rebagliati Martins; Oncologia, Lima
Hospital Nacional Guillermo Almenara Irigoyen; Oncology, Lima
Instituto Nacional de Enfermedades Neoplasicas, Lima
Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology, Taipei
Chang Gung Medical Foundation-Taipei, Taoyuan District
Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Hämatologie & Hämostaseologie, Vienna
Fov. Onk. Egyesitett Szent Istvan es Szent Laszlo Korhaz; Dept Of Bone Marrow Transplant, Budapest
National Kidney and Transplant Institute; Chemotherapy Unit, Diliman, Quezon City
St Luke'S Medical Centre; Oncology, Quezon City
National Institute of Oncology, A Dept of Internal Medicine, Budapest
North Shore Hospital; Haematolgy, Auckland
Hospital Italiano; Haemathology, Buenos Aires
Hospital Carlos Andrade Marin; Servicio de Oncología, Quito
Peter Maccallum Cancer Institute; Medical Oncology, Melbourne
Alfred Hospital; Bone Marrow Transplant Unit, Melbourne
Frankston Hospital; Oncology/Haematology, Frankston
Border Medical Oncology; Murray Valley Private Hospital, Wodonga
University of Debrecen Medical and Health Science Center, Institute of Internal Medicine, Hematology, Debrecen
Princess Alexandra Hospital Woolloongabba; Clinical Hematology and Medical Oncology, Woolloongabba
Greenslopes Private Hospital; Gallipoli Research Centre, Greenslopes
Royal Adelaide Hospital; Haematology, Institute of Medical Veterinary Science, Adelaide
HOSPITAL PRIVADO - CENTRO MEDICO DE CÓRDOBA; Dpto Oncología, Córdoba
Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt., Salzburg
Ashford Cancer Center Research, Kurralta Park
Cebu Cancer Institute; Perpetual Succour Hospital, Cebu
Fremantle Hospital; Haematology, Fremantle
Lkh-Univ. Klinikum Graz; Klinik Für Innere Medizin I, Graz
Universitätsspital Zürich; Klinik für Onkologie, Zurich
Az. Osp. S. Luigi Gonzaga; Malattie Apparato Respiratorio 5 Ad Indirizzo Oncologico, Orbassano
Charité-Universitätsm. Berlin; Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunolo., Berlin
Charité; Onkologie & Hämatologie, Berlin
A.O. Universitaria S. Giovanni Battista-Molinette Di Torino; Ematologia 1, Turin
King Chulalongkorn Memorial Hospital; Division of Hematology, Department of Medicine, Bangkok
National Cancer Inst., Bangkok
Rajavithi Hospital; Medicine, Bangkok
Siriraj Hospital; Division of Hematology, Department of Medicine, Bangkok
Hospital Pulau Pinang, George Town
Hospital Español; Hematología Sala 19, Mexico City
Ch Jacques Puel;Oncologie Medicale, Rodez
Institut J Paolii Calmettes; Onco Hematologie 1, Marseille
Centre Francois Baclesse; Comite 2, Caen
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Hematologia, A Coruña
Universitätsklinikum Greifswald Klinik für Innere Medizin C und Poliklinik, Greifswald
ASST DI MONZA; Ematologia, Monza
Asklepios Klinik St. Georg; Allgemeine Innere Medizin, Hamburg
Instituto Biomedico De Investigacion A.C., Aguascalientes
Facharztzentrum Eppendorf, Studien GbR, Hamburg
Chu Site Du Bocage;Hematologie Clinique, Dijon
Skånes University Hospital, Skånes Department of Onclology, Lund
Complejo Hospitalario de Jaen- Hospital Universitario Medico Quirurgico; Servicio de Hematologia, Jaén
Universitätsklinikum Schleswig-Holstein / Campus Lübeck, Med. Klinik I, Hämatologie/Onkologie, Lübeck
Klinikum Oldenburg gGmbH; Klinik für Onkologie und Hämatologie, Oldenburg
Irccs Policlinico San Matteo; Divisione Di Ematologia, Pavia
Forsyth Regional Cancer Center; Piedmont Hematology/Oncology Associates, Winston-Salem
Northeast Oncology Associates, Concord
Hospital Universitario Clínico San Carlos; Servicio de Hematología, Madrid
Hospital Universitario la Paz; Servicio de Hematologia, Madrid
DIAKO Ev. Diakonie-Krankenhaus Bremen GmbH; Med. Klinik II; Hämatologie und internistische Onkologie, Bremen
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga
Charleston Cancer Center, Charleston
Northwest Georgia Oncology Centers, Marietta
KRH Klinikum Siloah Medizinische Klinik III, Hanover
Polyclinique Kenval ; Radiotherapie Oncologie, Nîmes
Hopital Purpan; Hematologie Clinique, Toulouse
Clinique Pasteur; Oncologie Medicale, Toulouse
St. Bernward-Krankenhaus, Hildesheim
Uni Medical Center; Division Of Hemotology/Oncology, Jacksonville
Institut Bergonie; Hematologie Oncologie, Bordeaux
Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie, Bordeaux
Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica, Aviano
A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia; Clinica Ematologica, Udine
Florida Cancer Specialists, West Palm Beach
Hopital De Haut Leveque; Hematologie Clinique, Pessac
Hopital Saint Eloi; Hematologie Oncologie Medicale, Montpellier
Klinik Fulda; Abt. Itz, Fulda
Hospital Clinico Universitario de Salamanca;Servicio de Hematologia, Salamanca
Hopital Bretonneau; Hematologie Therapie Cellulaire, Tours
Georg-August-Uniklinik ; Zentrum Innere Medizin Abt. Hämatologie & Onkologie, Göttingen
Hospital Universitario de Canarias;servicio de Oncologia, San Cristóbal de La Laguna
Hopital Albert Michallon; Oncologie, La Tronche
Hospital Universitario Marques de Valdecilla; Servicio de Hematologia, Santander
Otto von Guericke Uni Magdeburg Uniklinik; Hämatologie/Onkologie, Magdeburg
Klinikum Magdeburg gemeinnützige GmbH; Klinik Haematologie und Onkologie, Magdeburg
Srinagarind Hospital, Khon Kaen Uni ; Dept of Medicine, Khon Kaen
A.O. Universitaria Policlinico S.Orsola-Malpighi Di Bologna, Bologna
Hospital Universitario Virgen del Rocio; Servicio de Hematologia, Seville
Az. Osp. Arcispedale S. Maria Nuova; U.O. Di Ematologia, Reggio Emilia
ICL; Hematologie, Saint-Priest-en-Jarez
Helios Klinik Wuppertal; Medizinische Klinik I, Wuppertal
Kliniken St. Antonius; Zentrum Für Innere Medizin, Haematologie/Onkologie, Wuppertal
Ospedale Regionale Di Parma; Divisione Di Oncologia Medica, Parma
Klinikzentrum Mitte; Medizinische Klinik Gastroenterologie Haematologie / Onkologie, Dortmund
St. Johannes Hospital; Abt. Innere Medizin, Dortmund
Prosper-Hospital, Medizinische Klinik I, Recklinghausen
Hospital Universitario la Fe; Servicio de Medicina Intena, Valencia
Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia
Hospital de Basurto; Servicio de Hematologia, Bilbao
St. Joseph Mercy Hospital; Department of Oncology, Ann Arbor
Westfälische Wilhelms-Universität Münster, Medizinische Klinik und Poliklinik A, Münster
Hospital de Galdakano, Galdakano
Centre Hospitalier Uni Ire; Service de Medecine D, Angers
Hospital Universitario Miguel Servet; Servicio Hematologia, Zaragoza
Chiang Mai Uni Hospital; Division of Hematology,Dept of Medicine,Faculty of Medicine, Chiang Mai
St Antonius Hospital; Haematologie/Onkologie, Eschweiler
Klinikum Mutterhaus der Borromaeerinnen gGmbH; Haematologie/Onkologie, Trier
Krankenhaus der Barmherzigen Brüder Trier; Innere Medizin I, Hämatologie / Internistische Onkologie, Trier
Hopitaux De Brabois; Hematologie Medecine Interne, Vandœuvre-lès-Nancy
Ospedale Santa Chiara; Unita Operativa Di Ematologia, Pisa
St Marien Krankenhaus; Medizinische Klinik Iii, Siegen
Kath.Krankenhaus Hagen gem.GmbH St.-Marien-Hospital, Hagen
Märkische Kliniken GmbH, Klinikum Lüdenscheid; Hämatologie / Onkologie, Lüdenscheid
Hopital Claude Huriez; Hematologie, Lille
Evang.Krankenhaus Abt. Hämatologie und Onkologie, Hamm
St.-Marien-Hospital Klinik Knappenstraße; Klinik für Hämatologie und Onkologie, Hamm
Krankenhaus Nordwest Medizinische Klinik, Frankfurt
Chu Estaing; Cons Hemato Medecine Interne, Clermont-Ferrand
Ospedale Gen.Le Prov.Le 'C.G.Mazzoni'; Ematologia, Ascoli Piceno
Hospital Universitario Dr. Jose E. Gonzalez; Haematology, Monterrey
HSK Dr.-Horst-Schmidt-Kliniken; Innere Medizin I Kardiologie; Angiologie und Intensivmedizin, Wiesbaden
Hopital Saint Jean; Hematologie, Perpignan
University of Kansas Medical Center; Department of Hematology, Kansas City
Universitaetsklinikum des Saarlandes; medizinische Klinik und Poliklinik; Innere Medizin I, Homburg/Saar
Klinikum der Stadt Ludwigshafen; Medizinische Klinik A, Ludwigshafen
Klinikum Mannheim III. Medizinische Klinik, Mannheim
Centre Leon Berard; Departement Oncologie Medicale, Lyon
Ch Lyon Sud; Hemato Secteur Jules Courmont, Pierre-Bénite
Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica, Bari
Clinique Victor Hugo; Chimiotherapie, Le Mans
Eberhard-Karls-Universität Tübingen; Medizinische Klinik I, Tübingen
Akademiska sjukhuset, Onkologkliniken, Uppsala
Institut Curie; Oncologie Medicale, Paris
Hopital Saint Louis ; Service d Oncologie Medicale Fougere 6 (Pr Misset), Paris
Hopital Pitie Salpetriere; Hematologie Clinique, Paris
Städtisches Klinikum Karlsruhe gGmbH, II. Medizinische Klinik, Karlsruhe
St. Vincentius Kliniken Ag; Medizinische Klinik Abt. 2, Karlsruhe
Cancer Therapy & Research Center, San Antonio
University of Colorado Cancer Center Department of Hematology, Aurora
Hopital Sud; Hematologie Clinique, Salouël
Clinique Claude Bernard; Onco Hematologie, Albi
Klinikum der Universitaet Muenchen; Campus Großhadern; Medizinische Klinik III und Poliklinik, München
Clinique Pont de Chaume; Oncologie Et Radiotherapie, Montauban
Tagesklinik Landshut; Hämatologie/Onkologie, Landshut
Länssjukhuset; Medicinkliniken, Sundsvall
CH Dptal Les Oudairies; Hematologie Oncologie, La Roche-sur-Yon
Hopital De La Miletrie; Hematologie Et Oncologie Medicale, Poitiers
Università Cattolica Del Sacro Cuore S.S. Giovanni Paolo Ii; Uoc Di Onco-Ematologia, Campobasso
Hopital Uni Ire Dupuytren; Hematologie, Limoges
Universitätsklinikum Ulm; Medizinische Uni-Klinik III Abt. Innere Medizin III Hämatologie u. Onkolo., Ulm
Kenmar Research Inst., Whittier
Uni of California - San Diego; Cancer Center & Dept of Medicine, La Jolla
Gesundheitszentrum St. Marien GmbH; Med. II, Hämatologie/Onkologie, Amberg
Seamen' Hospital' Dept. of haematology, Klaipėda
Institut Gustave Roussy; Unite D'Hematologie, Villejuif
Ospedale Ferrarotto; Divisione Di Ematologia, Via S. Sofia 78
Providence Portland Medical Center, Portland
Northwest Medical Specialties B, Federal Way
Rainier Physicians, Puyallup
Northwest Medical Specialties, Tacoma
Cancer Hospital Chinese Academy of Medical Sciences., Beijing
Beijing Cancer Hospital, Beijing
Beijing Union Hospital, Beijing
General Hospital of Chinese PLA; Department of Hematology, Beijing
N.N.Blokhin Russian Cancer Research Center; Dept. of Chemotherapy & Hemoblastosis, Moscow
Haematology Research Center; Haematology, Moscow
Semashko Central Clinical Hospital Moscow; Hematology, Moscow
Research Inst. of Hematology & Blood Transfusion ; Hematology, Saint Petersburg
Fudan University Shanghai Cancer Center, Shanghai
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
Changhai Hospital of Shanghai, Shanghai
The Second Affiliated Hospital of Soochow University, Suzhou
First Affiliated Hospital of Soochow University, Suzhou
Tianjin Institute of Hematology & Blood Diseases Hospital, Tianjin
Fujian Cancer Hospital, Fuzhou
Republican Clinical Oncologic Dispensary of Republic Of Tatarstan, Kazan'
Oncólogos de Occidente, Pereira
The First Affiliated Hospital of The Fourth Military Medical University (Xijing Hospital), Xi'an
Uni of Texas Southwestern Medical Center, Dallas
Fundaleu; Haematology, Buenos Aires
Hospital Britanico; Haematology, Buenos Aires
Centro Goiano de Oncologia - CGO, Goiânia
Hospital de Caridade de Ijui; Oncologia, Ijuí
Hospital das Clinicas - UFRGS; Hematologia, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
Hospital das Clinicas - UNICAMP, Campinas
Faculdade de Medicina do ABC - FMABC; Oncologia e Hematologia, Santo André
Santa Casa de Misericordia de Sao Paulo; Hematologia e Hemoterapia, São Paulo
Hospital das Clinicas - FMUSP; Hematologia, São Paulo
Tom Baker Cancer Centre; Dept of Medicine, Calgary
Cross Cancer Institute ; Dept of Medical Oncology, Edmonton
Cancer Care Manitoba, Winnipeg
Moncton Hospital, Moncton
Health Science Centre, St. John's
QEII HSC; Oncology, Halifax
Cancer Centre of Southeastern Ontario; Kingston General Hospital, Kingston
Credit Valley Hospital/Carlo Fidani Peel Regional Cancer Centre, Mississauga
Toronto Sunnybrook Regional Cancer Centre, Toronto
University Health Network; Princess Margaret Hospital; Medical Oncology Dept, Toronto
Windsor Regional Cancer Centre, Windsor
Hopital Charles Lemoyne; Centre Integre de Lutte Contre Le Cancer de La Monteregie, Greenfield Park
Mcgill University - Royal Victoria Hospital; Oncology, Montreal
McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal
Hopital de L'Enfant-Jesus; Hematology, Québec
Chuq - Hopital Hotel Dieu de Quebec; Oncology, Québec
Allan Blair Cancer Centre, Regina
Saskatoon Cancer Centre; Uni of Saskatoon Campus, Saskatoon
Organizacion Sanitas Internacional, Bogotá
Hospital Pablo Tobon Uribe, Medellin-Antioquia
Queen Elizabeth Hospital; Clinical Oncology, Hong Kong
Queen Mary Hospital; Dept of Medicine, Hong Kong
Uni of Auckland; Dept of Molecular Medicine & Haematology, Auckland
Christchurch Hospital; Canterbury Health Laboratories, Christchurch
Severance Hospital - Yonsei University; Medicine Dept., Seoul
Instituto Cancerologia Medellin; Clinica Las Americas, Medellín
Fakultni nemocnice Brno; Interni hematoonkologicka klinika, Brno
Fn Hr. Kralove; IV. Interni Hematologicka Klinika, Hradec Králové
Fakultni nemocnice Olomouc; Hemato-onkologicka klinika, Olomouc
Fakultni Nemocnice Plzen, Hematologicko-Onkologicke Oddeleni, Plzen - Lochotin
Fakultní Nemocnice Královské Vinohrady; Hematologická Klinika, Prague
VshEOBECNÁ FAKULTNÍ NEMOCNICE; I. INTERNI KLINIKA, Prague
Teodoro Maldonado Carbo Hospital; Oncology Service, Guayaquil
Hospital Solca Quito; Oncologia, Quito
Hopital de L'Archet; Hematologie Clinique, Nice
Carl-Thiem-Klinik Cottbus; Medizinische Klinik, Cottbus
Universitätsklinikum Leipzig Medizinische Klinik II Gastroenterolog. u. Hepatolog., Leipzig
Klinikum St.Georg gGmbH Klinik für Internistische Onkologie und Hämotologie, Leipzig
Georgios Papanikolaou Hospital; Hematology Department, Thessaloniki
Univ. Cattolica La Sapienza; Cattedra Di Ematologia, Rome
Uni Hospital Santariskiu Clinic; Haematology, Vilnius
Col Instituto Tecnologico Y Estudios Superiores de Monterrey, Monterrey
Centro Hemato Oncologico Paitilla, Panama City
Hospital Nacional Almanzor Aguinaga Asenjo; Unidad De Investigacion Del Servicio De Oncologia Medica, Chiclayo
Hospital Nacional LNS dela Policia Nacional del Perú. Unidad Onco; Deapartamento de Oncología, Lima
Szpital Specjalistyczny Podkarpacki Ośrodek Onkologiczny, Brzozów
Szpital Uniwersytecki W Krakowie; Klinika Hematologii, Krakow
Medical University School; Dept. of Haematology, Lodz
Katedra i Klinika Hematoonkologii i Transplantacji Szpiku; Uniwersytetu Medycznego w Lublinie, Lublin
Zaklad Opieki Zdrowotnej Mswia; Oddzial Chemioterapii, Olsztyn
Samodzielny Publiczny Centralny Szpital Kliniczny; Haematology Dept., Warsaw
Centralny Szpital Kliniczny Mswia; Klinika onkologii, hematologii i chorob wewnetrznych, Warsaw
Centrum Onkologii - Inst.Im. Marii Sklodowskiej-Curie; Lymphoma Dept., Warsaw
HUC; Servico de Hematologia, Coimbra
IPO de Lisboa; Servico de Hematologia, Lisbon
Hospital de Sao Joao; Servico de Hematologia Clinica, Porto
National Cancer Inst. ; Dept. of Chemotherapy, Bratislava
Samsung Medical Centre; Oncology, Seoul
Asan Medical Center, Uni Ulsan Collegemedicine; Dept.Internal Medicine / Divisionhematology/Oncology, Seoul
Korean Cancer Center Hospital; Oncology, Seoul
Hospital Mutua de Terrassa; Servicio de Hematologia, Terrassa
Hospital de la Santa Creu i Sant Pau; Servicio de Hematologia, Barcelona
Hospital Universitari Vall d'Hebron; Servicio de Hematologia, Barcelona
Hospital Clínic i Provincial; Servicio de Hematología y Oncología, Barcelona
Hospital Duran i Reynals; Servicio de Hematologia, Barcelona
Skånes Universitetssjukhus; Kliniska Forskningsenheten Onkologimottagning medicinsk behandling, Malmo
Veterans General Hospital; Division of Oncology, Taipei
Birmingham Heartlands Hospital; Department of Haematology, Birmingham
Bradford Royal Infirmary; Haematology Department, Bradford
North Hampshire Hospital; Dept. of Haematology, Hampshire
Princess Alexandra Hospital; Department of Haematology, Harlow
Leicester Royal Infirmary; Dept. of Medical Oncology, Leicester
Royal Liverpool Uni Hospital; Haematology, Liverpool
St. George'S Hospital; Haematology, London
Hillingdon Hospital, Middx
Churchill Hospital; Oxford Cancer and Haematology Centre, Oxford
Royal Hallamshire Hospital; Haematology Dept, Sheffield
Weston Park Hospital; Cancer Clinical Trials Centre, Sheffield
The Royal Wolverhampton Hospitals NHS Trust; Department of Haematology, Wolverhampton
Collaborators (1)
Genentech, Inc.
INDUSTRY
Hoffmann-La Roche
INDUSTRY