92
Participants
Start Date
October 29, 2007
Primary Completion Date
June 30, 2013
Study Completion Date
January 31, 2014
hydroxychloroquine
see arm description, the first 10 week cycle is call initiation cycle, Post the 10 week cycle of just HCQ, 4 week cycles are called Maintenance Cycles
temozolomide
TMZ daily 75mg/m2 for 6wks with RT+HCQ (TMZ is given only during Initiation cycle)
pharmacological study
Seven samples in total will be collected baseline, initiation cycle -week3-4, week9-10, Maintenance Cycle 1 Week 4 (C1W4), Cycle2 Week4, Cycle3 Week4, Cycle6 Week4
Radiation
Radiation during the first six weeks of treatment Monday-Friday
Winship Cancer Institute of Emory University, Atlanta
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Massachusetts General Hospital, Boston
Wake Forest University Comprehensive Cancer Center, Winston-Salem
Case Comprehensive Cancer Center, Cleveland
Abramson Cancer Center of the University of Pennsylvania, Philadelphia
National Cancer Institute (NCI)
NIH
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
OTHER