Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus

NACompletedINTERVENTIONAL
Enrollment

4

Participants

Timeline

Start Date

May 31, 2007

Primary Completion Date

October 31, 2012

Study Completion Date

October 31, 2012

Conditions
Nephrogenic Diabetes Insipidus
Interventions
DRUG

sildenafil

25 mg quaque die (QD) or 50 mg QD x 4 days based on subject weight

DRUG

calcitonin

one nasal spray daily for 4 days

DRUG

hydrochlorothiazide/amiloride

25 mg/2.5 mg BID or 50 mg/5 mg BID x 8 days depending on subject weight

DRUG

indomethacin

50 mg QD or 50 mg BID x 8 days depending on subject weight

DRUG

Placebo for sildenafil

one tablet daily for 4 days

DRUG

placebo for calcitonin

one nasal spray daily

Trial Locations (2)

80045

University of Colorado at Denver and Health Sciences Center, Aurora

Unknown

University of Aarhus, Aarhus

All Listed Sponsors
collaborator

University of Aarhus

OTHER

lead

University of Colorado, Denver

OTHER

NCT00478335 - Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus | Biotech Hunter | Biotech Hunter