39
Participants
Start Date
October 31, 2007
Primary Completion Date
March 31, 2011
Study Completion Date
June 30, 2011
alpha-lipoic acid
Supplements (1200mg once a day) or placebo will be administered to each patient prior to first cisplatin treatment and continue until 3 months after last treatment.
Audiology
otoscopy, immittance screening, noise exposure questionnaire and individualized behavioral pure-tone in the convention and high-frequency ranges.
laboratory biomarker analysis
Plasma concentrations of Malondialdehyde (MDA) will be measures as an indicator of oxidative stress.
Placebo
Placebo will be administered to each patient prior to first cisplatin treatment and continue until 3 months after last treatment.
VA Medical Center, Portland, Portland
Oregon Health & Science University, Portland
Oregon Health and Science University
OTHER
US Department of Veterans Affairs
FED