836
Participants
Start Date
May 15, 2007
Primary Completion Date
January 21, 2010
Study Completion Date
May 14, 2018
Leflunomide
Oral repeating dose
Methotrexate
Oral or parenteral repeating dose
Ocrelizumab
Intravenous repeating dose (200mg)
Ocrelizumab
Intravenous repeating dose (500mg)
Placebo
Intravenous repeating dose
Clinica San Felipe; Consultorio de Reumatología, Lima
Hospital Nacional Edgardo Rebagliati Martins; Servicio de Reumatología, Lima
Bolnica dr. Petra Drzaja, Klinicni center Ljubljana; Klinicni oddelek za revmatologijo, Ljubljana
CHUV; Hôpital orthopédique, Rhumatologie, Lausanne
CHU Brugmann (Victor Horta), Brussels
Orszagos Reumatologiai Es Fizioterapias Intezet, Budapest
Budai Irgalmasrendi Kórház KHT. II. Reumatológia, Budapest
ZNA Jan Palfijn, Merksem
UZ Leuven Gasthuisberg, Leuven
Debreceni Egyetem Orvos- és Egészségtudományi Centrum; Belgyógyászati Intézet, Reumatológiai Tanszék, Debrecen
Princess Alexandra Hospital; Rheumatology, Woolloongabba
Sunshine Coast Rheumatology Research Unit, Maroochydore
CHU de Charleroi, Charleroi
GHdC Site Saint-Joseph, Gilly (Charleroi)
Royal Perth Hospital; Rheumatology, Shenton Park
Timaru Hospital, Timaru
AZ Sint Jan, Bruges
Universitätsspital Zürich; Klinik für Rheumatologie, Zurich
UZ Gent, Ghent
Vas Megye Es Szombathely M.J.V. Markusovszky Korhaza, Szombathely
Arthritis & Osteoporosis Center, Brooklyn
Hospital de Jerez de la Frontera; Servicio de Reumatologia, Jerez de la Frontera
Andrew Porges Pc, Roslyn
Rheumatology Associates of Long Island, Smithtown
The Center of Rheumatology, Albany
Fondation Hopital Saint Joseph; Rhumatologie, Marseille
Schlosspark Klinik; Abt. Rheumatologie, Berlin
Aair Research Center, Rochester
Southern Tier Arthritis & Rheumatism, Olean
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Reumatologia, A Coruña
Advanced Rheumatology & Arthritis Research Center, Wexford
Università Degli Studi Di Genova - Dimi; Reumatologia, Genoa
Arthritis Associates, Erie
Rheumatology Associates of NW Pa, Erie
East Penn Rheumatology Associates, Pc, Bethlehem
Hospital General Universitario de Guadalajara; Servicio de Reumatologia, Guadalajara
Arthritis Group, Philadelphia
Clinical Research Center of Reading, Wyomissing
Javed Rheumatology Associates, Inc., Newark
Rheumatolgy Consultants of Deleware, Lewes
Center For Rheumatology & Bone Research, Wheaton
Unidad de Reumatologia Rehabilitacion Integral; Centro Medico Del Angel, Mexicali
Johns Hopkins University; Department of Rheumatology, Baltimore
Arthritis Clinic of Northern Virginia, Arlington
Sentara Medical Group, Norfolk
Irccs Policlinico San Matteo; Reumatologia Adulti, Pavia
Physicians East Pa, Greenville
Arthritis Associates, Belmont
Hospital Universitario 12 de Octubre; Servicio de Reumatologia, Madrid
Metrolina Medical Research, Charlotte
Carolina Bone & Joint P.A., Charlotte
Unifour Medical Research Associates, Hickory Grove
Asheville Arthritis & Osteoporosis Center, PA, Asheville
Spartanburg Medical Research, Spartanburg
Low Country Research Center, Charleston
Medical Uni of South Carolina, North Charleston
Palmetto Clinical Trial Services, LLC, Fountain Inn
Csi Research, Inc., Cumming
Marietta Rheumatology Associates, Pc, Marietta
Atlanta Center For Clinical Research., Atlanta
Medizinische Hochschule Zentrum Innere Medizin Abt.Klinische Immunologie und Rheumatologie, Hanover
Jacksonville Center For Clinical Research, Jacksonville
Centro de Infusion Marbella; Consultorios Royal Center Num 214, Panama City
Hospital Univ. Central de Asturias; Servicio de Reumatologia, Oviedo
Center For Arthritis; Research Dept, South Miami
Arthritis & Rheumatism; Disease Specialities, Aventura
Florida Medical Center, Zephyrhills
SW Florida Clinical Research, Tampa
Tampa General Hospital; Rheumatology Research Dept, Tampa
Burnette & Silverfield, MDS, Tampa
Sarasota Arthritis Center; Research Dept, Sarasota
Hopital Lapeyronie; Immunologie Rhumatologie, Montpellier
Arthritis Center Palm Harbor, Palm Harbor
Arthritis Rsrch of Florida, Inc., Palm Harbor
Rheumatology Associates, Birmingham
Internistisches Praxiszentrum Am Krankenhaus Balserische Stiftung; Innere Medizin / Rheumatologie, Giessen
Rheumatology Associates of North Alabama, Huntsville
Pinnacle Research Group; Llc, Central, Anniston
Hospital Clinico Universitario de Salamanca; Servicio de Reumatologia, Salamanca
Rheumatology Consultants, Knoxville
Arthritis Group, Memphis
Ramesh Gupta - PP, Memphis
West Tennessee Research Institute, Jackson
North Mississippi Medical Ctr; Internal Medicine Associates, Tupelo
Jackson Arthritis Clinic, Flowood
Hospital Sierrallana; Servicio de Reumatologia, Torrelavega
Kentuckiana Center For Better Bone & Joint Healthx, Louisville
Bluegrass Comm Research, Inc., Lexington
Arcispedale Santa Maria Nuova; Reumatologia, Reggio Emilia
Center For Arthritis & Osteoporosis, Elizabethtown
University Hospitals Case Medical Center, Cleveland
Paramount Medical Research, Middleburg Heights
David Mandel Inc, Mayfield
Unidad De Enfermedades; Cronico Degenerativas, SC., México
Consultorio Privado Dr. Javier Orozco, Guadalajara
Deaconess Arthritis Center; Rheumatic Disease Study Group, Cincinnati
Stat Research, Inc, Dayton
CH Jean Rougier; Rhumato Reed Fonctionnelle, Cahors
Diagnostic Rheumatology & Research, Indianapolis
Medical Specialists Clinical Research Center, Munster
Klinik Duisburg; Klinik Für Rheumatologie, Duisburg
Hospital de Basurto; Servicio de Reumatologia, Bilbao
Office of Andrew Sulich, Md, Saint Clair Shores
Clinsite;Research Division of Integrated Health Associates, Ann Arbor
Fiechtner Research Inc, Lansing
Rheumatology, P.C.; Medical Arts Building, Kalamazoo
Borgess Research Institute, Kalamazoo
Rheumapraxis an der Hase, Osnabrück
Klinik der Uni zu Köln; Klinik für Innere Medizin, Cologne
Praxis Dr. med. Reiner Kurthen, Aachen
Physician'S Clinic of Iowa, Cedar Rapids
Rheumatic Disease Center, Glendale
Gundersen Clinic Ltd;Sec. Rheumatology/Dept. of Internal Med, Onalaska
St. Paul Rheumatology, Eagan
Uniklinik Mainz; I. Medizinische Klinik, Mainz
Park Nicollet Inst. ; Rtrc, Minneapolis
St Luke's Whiteside Research, Duluth
St. Mary'S Duluth Clinic Health System; Rheumatology Dept, Duluth
Az. Osp. Pisana Ospedale S. Chiara; U.O. Di Reumatologia, Pisa
Evangelisches Krankenhaus Hagen-Haspe Rheumaklinik, Hagen
Uni Hospital Linkoeping; Dept. of Rheumatology, Linköping
St. Alexius Medical Center; Arthritis Clinic, Bismarck
Hopital B Roger Salengro; Rhumatologie, Lille
Illinois Bone & Joint Inst., Morton Grove
Evanston Northwestern Healthcare; Rheumatology, Evanston
Endokrinologikum Frankfurt; Rheumatologie & Gynäkologie, Frankfurt
Uni of Chicago, Chicago
Quad City Rheumatology, Sc, Moline
Springfield Clinic, Springfield
David S Rosenberg, Florissant
Clayton Medical Research, St Louis
Physicians Group, LC DBA Rheumatology & Internal Medicine Associates, St Louis
Arthritis Consultants, St Louis
St. John'S Health System Inc.; St. John'S Medical Research, Springfield
Uni of Kansas Medical Center, Kansas City
Hopital Louis Pasteur; Service De Medecine Interne et de Rhumatologie, Colmar
Westroads Medical Group, Omaha
Rheumapraxis PD Dr.med. Bernhard Heilig, Heidelberg
UNI-Klinikum Heidelberg Medizinische Klinik Innere Medizin V, Heidelberg
Fachärzte für Innere Medizin - Rheumatologie - Dr. med. Ino Gao und Dr. med. Maria Anna Meier, Heidelberg
Baton Rouge Clinic, Amc, Baton Rouge
CHI St. Vincent Medical Group Hot Springs, Hot Springs
CH Du Mans; Rhumatologie, Le Mans
Little Rock Diagnostic Clinic, Little Rock
Health Research of Oklahoma, Llc, Oklahoma City
Oklahoma Medical Research Foundation, Oklahoma City
Oklahoma Center For Arthritis Therapy & Research, Tulsa
Healthcare Research Consultants, Tulsa
Southwest Rheumatology, Mesquite
Akademiska sjukhuset, Reumatologkliniken, Uppsala
Arthritis Care and Research Centre, Dallas
Metroplex Clinical Research, Dallas
Arthritis Centers of Texas, Dallas
Uni of Texas Southwestern Medical Center; Internal Medicine, Dallas
Hopital Cochin; Rhumatologie A, Paris
Hopital Cochin; Rhumatologie B, Paris
Hopital De Bois Guillaume; Rhumatologie, Bois-Guillaume
Texas Research Center, Sugar Land
Radiant Research, San Antonio
Texas Arthritis Research Center; Center for Arthritis & Rheumatic Diseases, San Antonio
Austin Rheumatology Research, Austin
Walter F. Chase, Md, Pa, Austin
Aamr Research Clinic, Amarillo
Universitätsklinikum Freiburg; Medizinische UNI-Klinik; Abt. Innere Medizin - VI Rheumatologie, Freiburg im Breisgau
Amarillo Center For Clinical Research, Amarillo
Arthritis & Osteoporosis Associates, LLP, Lubbock
University of Colorado Cancer Center, Aurora
Klinikum der Universitat Munchen; Bereich Pettenkoferstr; Rheumaeinheit der medizinischen Klinik IV, München
Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs, Colorado Springs
Idaho Arthritis Center, Meridian
Intermountain Orthopaedics, Boise
Coeur D'Alene Arthritis Clinic, Coeur d'Alene
Uni of Utah Medical Center, Salt Lake City
Clinica San Jose Obregon; Rheumatology, Obregón
Arizona Arthritis & Rheumatology Research, Pllc, Mesa
Arthrocare, Arthritis Care and Research, P.C., Mesa
Catalina Pointe Clinical Research, Inc., Tucson
Uni of Arizona Health Science Center; Dept of Rheumatology/Immunology, Tucson
Uni of Southern California School of Medicine, Los Angeles
Pacific Arthritis Care Center, Los Angeles
Arthritis Treatment Center of South Bay, Torrance
Valerius Medical Group & Research Ctr of Greater Long Beach, Los Alamitos
Private Practice, Long Beach
Allergy & Rheumatology Centre, La Jolla
Ucsd, Dept of Medicine; Rheumatology, San Diego
San Diego Arthritis Med Clnc, San Diego
Stanford Uni Medical Center; Divison of Rheumatology, Palo Alto
East Bay Rheumatology, San Leandro
Portland Rheumatology Clinic Llc, Lake Oswego
Universitätsklinikum Würzburg; Medizinische Klinik und Poliklinik II; Hämatologie / Onkologie, Würzburg
Providence Arthritis Center, Portland
Pro Research, Eugene
Bend Memorial Clinic, Bend
Seattle Rheumatology Associates, Seattle
Office of George Krick, Md, Tacoma
Tacoma Center For Arthritis Research, Tacoma
Vancouver Clinic; Research Dept, Vancouver
Clinical Trials Northwest, Yakima
Arthritis Northwest, Spokane, Spokane
Revmatologicky Ustav, Prague
Meir Medical Center; Heamatology Dept, Kfar Saba
Beilinson Medical Center; Rheumatology, Petah Tikva
Assaf Harofe; Dept of Medicine B, Beer Yaakov
Sourasky / Ichilov Hospital; Rheumatology, Tel Aviv
Soroka Medical Center; Reumatology, Beersheba
Centro Internacional de Pesquisa; Reumatologia, Goiânia
Arthritis & Osteoporosis Center P.C., Camden
New England Research Associates, Trumbull
Iu Outpatient Clinical Research Facility, Indianapolis
Clinical Pharmacology Study Group, Worcester
Seacoast Arthritis and Osteoporosis Center, Dover
Nashua Rheumatology - Foundation Medical Partners, Nashua
Mark Fisher Md, Facr, Llc, Haddon Heights
Arthritis Rheumatic & Back Disease Associates, Voorhees Township
Arthritis Care & Diagnostic Center, Dallas
Organizacion Medica de Investigacion, Buenos Aires
Inst. de Rehabilitacion Psicofisica; Reumathology, Buenos Aires
CER Instituto Médico; REUMATOLOGÍA, San Juan Bautista
Centro de Estudos em Terapias Inovadoras - CETI, Curtiba
Hospital Universitario Clementino Fraga Filho - UFRJ; Reumatologia, Rio de Janeiro
Hospital das Clinicas - UNICAMP, Campinas
Hospital Abreu Sodre - AACD;Pesquisa Clinica, São Paulo
The Governors of the Uni of Alberta; Heritage Medical Research Centre, Edmonton
Arthritis Research Centre, Vancouver
Manitoba Clinic, Winnipeg
Wharton Medical Clinic; Burlington, Burlington
Mac Research Inc., Hamilton
K-W Musculoskeletal Research, Kitchener
St. Joseph'S Health Care Centre; Rheumatology, London
Credit Valley, Rheumatology, Mississauga
The Ottawa Hospital - Riverside Campus; the Arthritis Centre, Ottawa
University Health Network; Toronto Western Hospital, Toronto
Hopital Maisonneuve- Rosemont; Rheumatology, Montreal
Institut de Rhumatologie de Montreal, Montreal
Montreal Rheumatic Disease Centre, Montreal
Groupe de Recherche En Rhumatologie Et Maladies Osseuses, Québec
Clin. de Rhumatologie, Trois-Rivières
Royal Uni Hospital; Medicine Dept, Saskatoon
Hopital de L'Archet; Rhumatologie, Nice
Seihoku Chuoh Hospital; Department Of Rheumatology, Aomori
Univ. of Occupational and Environmental Health; Rheumatology, Clinical Immunology and Medicine, Fukuoka
National Hospital Organization Kyushu Medical Center; Rheumatology and Internal Medicine, Fukuoka
Higashihiroshima Memorial Hospital; Rheumatology, Internal Medicine, Hiroshima
Hokkaido Uni Hospital; Second Department of Internal Medicine, Hokkaido
Matsubara Mayflower Hospital; Rheumatology, Hyōgo
Sasebo Chuo Hospital ; Internal Medicine, Nagasaki
Osaka Minami Medical Center; Rheumatoid Arthritis, Osaka
Saitama Medical University Hospital ; Rheumatology and Applied Immunology, Saitama
Saitama Medical Center/School; Rheumatology, Clinical immunology, Saitama
Seirei Hamamatsu General Hospital; Rheumatology, Shizuoka
Jichi Medical School Hospital; Rheumatology and Clinical Immunology, Tochigi
Tokyo Medical & Dental University; Medicine & Rheumatology, Tokyo
Tokyo Women's Medical University, Tokyo
Academisch Medisch Centrum; Division of Clinical Immunology & Rheumatology, Amsterdam
Maxima Medisch Centrum; Rheumatology, Eindhoven
Hospital Alberto Sabogal Sologuren; Remautology, Callao
Szpital Uniwersytecki; nr 2 im. Dr J. Biziela, Bydgoszcz
Wojewodzki Szpital Zespolony; Oddzial Reumatologii, Elblag
Klinika Reumatologii I Chorób Wewn. Pum W Szczecinie; Samodzielny Publiczny Szpital Kliniczny Nr 1, Szczecin
Narodny Ustav Reumatickych Chorob - 34479; Rheumatology, Piešťany
Corporacio Sanitaria Parc Tauli; Servicio de Reumatologia, Sabadell
Hospital Universitario Infanta Cristina; Servicio de Reumatologia, Badajoz
Hospital Clinic i Provincial; Servicio de Reumatologia, Barcelona
Hospital Universitari de Bellvitge; Servicio de Reumatologia, Barcelona
Complejo Asistencial Universitario de Burgos; Servicio de Reumatología, Burgos
Chang Gung Medical Foundation - Kaohsiung; Rheumatology, Kaohsiung City
Lead Sponsor
Roche Pharma AG
INDUSTRY
Genentech, Inc.
INDUSTRY