Lapatinib in Combination With Radiation Therapy in Patients With Brain Metastases From HER2-Positive Breast Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

April 30, 2007

Primary Completion Date

December 31, 2009

Study Completion Date

June 30, 2012

Conditions
Breast CancerBrain Metastases
Interventions
DRUG

Lapatinib

Orally twice daily

PROCEDURE

Whole Brain Radiation

15 treatments over a period of 3 weeks

DRUG

Herceptin

Herceptin 4mg/kg loading dose then 2 mg/kg IV once weekly, then once every three weeks after cycle 3.

Trial Locations (3)

46202

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

02115

Brigham and Women's Hospital, Boston

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

Brigham and Women's Hospital

OTHER

collaborator

Breast Cancer Research Foundation

OTHER

collaborator

GlaxoSmithKline

INDUSTRY

lead

Nancy Lin, MD

OTHER